Subcutaneous Panniculitis-like T-Cell Lymphoma: Presentation of 2 Cases and Observations

Romidepsin Is Effective in Subcutaneous Panniculitis-Like T-Cell Lymphoma

“…Both entities are characterized by atypical lymphocytes that involve the subcutis in a lobular configuration with a rimming of individual adipocytes. 6,10,12,[17][18][19] For indolent disease presentations with a more generalized distribution, systemic biologic agents may be used, such as bexarotene and interferon, as well as low-dose chemotherapy with agents such as methotrexate. [1][2][3][4][7][8][9][10][11][12][13][14] HPS may be associated with 15% to 20% of presentations of SPTCL and carries a grim prognosis.…”

Aggressive subcutaneous panniculitis-like T-cell lymphoma with hemophagocytosis in two children (subcutaneous panniculitis-like T-cell lymphoma)

“…1,4,5,7,10,12,24,[26][27][28][29][30][31][32] There are only two previous reports of patients who responded to fludarabinebased chemotherapy. 33,34 There are a few reports of patients who received low-dose systemic chemotherapy, eg, cyclophosphamide, methotrexate, and chlorambucil.…”

“…Radiotherapy has been used for patients with localized disease, producing long-term remissions. 1,[5][6][7]28,32,36,37 Cyclosporine, in combination with chemotherapy or prednisolone, has been used with success in a handful of patients. [38][39][40] Stem-cell transplantation after high-dose chemotherapy has been described, with impressive response rates.…”

Subcutaneous Panniculitis-like T-cell Lymphoma: Review of Therapies

“…In general, for indolent local disease, local radiotherapy can be used as an effective treatment modality [3,10,13,18,27,28]. For indolent disease with a more generalized distribution, immunosuppressive agents such as prednisone and cyclosporine, or systemic biologic agents, such as bexarotene and interferon, as well as low-dose chemotherapy with agents such as methotrexate may be used.…”

“…Complete sustained remission with corticosteroids and MTX has been reported in one case report [29]. For aggressive presentations, combination chemotherapy such as CHOP (cyclophosphamide, Adriamycin, vincristine, prednisone), anthracycline-based regimens, fludarabine-based regimens, and rarely high-dose chemotherapy followed by hematopoietic stem cell transplant (SCT) with moderate success [3,10,14,19,27,28,[30][31][32][33][34] . Fludarabine-based chemotherapies have shown overall remission rates of more than 70% in a few case reports [35,36].…”