Subcutaneous panniculitis-like T-Cell lymphoma in a child presenting as an abdominal wall mass

Subcutaneous panniculitis‐like T‐cell lymphoma of the breast in an adolescent female: An uncommon presentation

“…To the Editor: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is one of the rarest subtypes of non-Hodgkin lymphoma (NHL) in children, constituting less than 1% of NHL and cutaneous lymphomas, 1,2 with limited literature in the pediatric population. 3,4 Our case represents the first case of breast SPTCL in the pediatric population.…”

“…12 Potential treatment modalities include observation, immunosuppression, chemotherapy, and radiotherapy. 3,13 Similar to the adults, pediatric case series have shown good treatment outcomes with dual immunosuppression (cyclosporin-A and prednisolone), particularly in the absence of HLH. 3 One of the largest reviews of pediatric non-anaplastic PTCL, SPTCL shows the best treatment outcome with the higher 5-year survival compared to the other pediatric PTCL.…”

“…3,13 Similar to the adults, pediatric case series have shown good treatment outcomes with dual immunosuppression (cyclosporin-A and prednisolone), particularly in the absence of HLH. 3 One of the largest reviews of pediatric non-anaplastic PTCL, SPTCL shows the best treatment outcome with the higher 5-year survival compared to the other pediatric PTCL. 14 The diagnosis of SPTCL is often delayed due to vague presentation and nonspecific early histopathological and imaging findings, requiring a high index of suspicion.…”

Subcutaneous panniculitis-like T-cell lymphoma of the breast in an adolescent female: An Uncommon presentation

“…SPTCL is one of the rarest subtypes of non-Hodgkin lymphoma (NHL) in children, constituting less than 1% of the NHL and the cutaneous lymphomas (2,3) with limited literature in the pediatric population (4,5).…”

“…The management of SPTCL in the pediatric population is variable and largely depends on the histopathological diagnosis and institutional preferences. Potential treatment modalities include observation, immunosuppression, chemotherapy, and radiotherapy (4,13). Similar to the adults, pediatric case series have shown good treatment outcomes with dual immunosuppression (cyclosporin-A and prednisolone) in childhood SPTCL, particularly in the absence of HLH (4).…”