Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases

Willemze, Rein; Jansen, Patty M.; Cerroni, Lorenzo; Berti, Emilio; Santucci, Marco; Assaf, Chalid; Dijk, Marijke R. Canninga‐van; Carlotti, A.; Geerts, Marie; Hahtola, Sonja; Hummel, Michael; Jeskanen, Leila; Kempf, Werner; Massone, Cesare; Ortiz‐Romero, Pablo L.; Paulli, Marco; Petrella, Tony; Ranki, Annamari; Peralto, J.L. Rodríguez; Robson, Alistair; Senff, Nancy J.; Vermeer, Maarten H.; Wechsler, Janine; Whittaker, Sean; Meijer, Chris J.L.M.

doi:10.1182/blood-2007-04-087288

Cited by 598 publications

(842 citation statements)

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“…In contrast to the ab cases, gd T-cell lymphoma are associated with a more aggressive clinical course and increased risk of developing hemophagocytic syndrome. 1,5,6 Although subcutaneous involvement of subcutaneous panniculitis-like T-cell lymphoma is often multifocal, the spread of disease to organs other than the skin and subcutaneous tissue is rare. Hypermetabolic infiltrative lesions suspicious for lymphomatous involvement of lung, omental soft tissue and lymph node have been reported in patients diagnosed with subcutaneous panniculitis-like T-cell lymphoma using PET-CT. [7][8][9] However, most of these reports lack histological confirmation.…”

Section: Discussionmentioning

confidence: 99%

“…Willemze et al in a large series of 63 cases of subcutaneous panniculitis-like T-cell lymphoma ab type, found hemophagocytosis in the bone marrow of 11 cases but no evidence of lymphoma. 6 Ghobrial et al examined 21 cases of subcutaneous panniculitislike T-cell lymphoma over a period of 30 years at the Mayo Clinic, and found lymphoma in only 1 of 20 bone marrow biopsies. However, it was unclear whether this positive case was of the ab phenotype as their series included both ab and gd type cases, and the case described was published prior to the 2008 WHO classification.…”

Section: Discussionmentioning

confidence: 99%

“…1,6 In Willemze et al's large series of 63 cases of subcutaneous panniculitis-like T-cell lymphoma with confirmed ab phenotype, 39 patients achieved complete remission after initial treatment, 15 patients had ongoing skin disease, and 9 patients died, including 7 with hemophagocytic syndrome. Hemophagocytic syndrome is considered a strong adverse prognostic indicator.…”

Section: Discussionmentioning

confidence: 99%

“…The 5-year survival for patients with subcutaneous panniculitislike T-cell lymphoma and hemophagocytic syndrome is significantly lower than those without hemophagocytic syndrome (46 vs 91%). 6 But the prognostic significance of other clinical features or laboratory abnormalities is not conclusive. Two of our three patients (cases 2 and 3) appear to have a more aggressive disease course.…”

Section: Discussionmentioning

confidence: 99%

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Bone marrow involvement by subcutaneous Panniculitis-like T-cell lymphoma: a report of three cases

et al. 2014

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Subcutaneous panniculitis-like T-cell lymphoma is a rare subtype of cutaneous T-cell lymphoma. Virtually all cases are confined to the subcutaneous adipose tissue. In this report, we describe the first small series of subcutaneous panniculitis-like T-cell lymphoma (three patients) with bone marrow involvement. All patients presented with skin or soft tissue nodules, fever, and constitutional symptoms, and were diagnosed with subcutaneous panniculitis-like T-cell lymphoma based on the characteristic morphologic and immunophenotypic features of the subcutaneous lesions. Bone marrow core biopsies in these cases showed focal involvement by lymphoma with pathologic features similar to those seen in the diagnostic biopsies. Our observations suggest bone marrow involvement by subcutaneous panniculitis-like T-cell lymphoma does occur, and can be identified histologically and confirmed using standard immunohistochemistry. Our findings raise awareness of bone marrow involvement in this rare entity. However, the incidence and significance of bone marrow involvement in subcutaneous panniculitis-like T-cell lymphoma requires further evaluation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Bone marrow involvement by subcutaneous Panniculitis-like T-cell lymphoma: a report of three cases

et al. 2014

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“…The annual incidence of cutaneous lymphoma is estimated to be from 0.5 to 1 per 1, 00,000 persons per year. [2] SPTCL is a rare extranodal non Hodgkin lymphoma (NHL) accounting for less than one percent of all NHL [1][2][3][4][5] and resembles certain benign panniculitis like lupus panniculitis and erythema nodosum clinically and histologically. We present the clinicopathological features of two such cases and discuss the differential diagnosis, immunohistochemical and molecular features of SPTCL…”

Section: Introductionmentioning

confidence: 99%

Subcutaneous Panniculitis- like T-Cell Lymphoma: Report of two cases

Kini¹,

John²,

Kini³

et al. 2014

Our Dermatol Online

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Subcutaneous panniculitis-like T-cell lymphoma is a distinct variant of cutaneous T-cell lymphoma, characterized by primary involvement of the subcutaneous fat in a manner mimicking panniculitis. It accounts for less than one percent of all non Hodgkin lymphoma. We describe two such patients who presented with cutaneous nodules. A 28 year old male presented with a one and a half month history of multiple subcutaneous nodules over the thighs, abdominal wall and chest. A clinical diagnosis of panniculitis was made. An excision biopsy of one the nodules was performed and the histopathology revealed subcutaneous panniculitis-like T-cell lymphoma. The other patient was a 44 year old male who underwent excision of a subcutaneous mass in the right thigh and on histopathological examination a diagnosis of subcutaneous panniculitis-like T-cell lymphoma was made. The patients received one cycle of CHOP (cyclophoshamide, vincristine, doxorubicin and prednisolone) regimen, followed by systemic steroids and were advised follow up.

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Cutaneous γδ T-Cell Lymphoma With Bilateral Ocular and Adnexal Involvement

Shunmugam¹,

Chan²,

O’Brart³

et al. 2011

Arch Ophthalmol

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was found in some of these nematodes. 6 These are mutualistic symbionts. Treatment with tetracyclines clears the Wolbachia from the worm, affecting embryogenesis and resulting in worm sterility. 6 This may prevent future episodes of uveitis. Doxycycline treatment showed no effect on Loa loa infections in humans because they do not possess Wolbachia. 6 Therefore, accurate identification of the nematode is essential when planning treatment. In conclusion, we report a case of bilateral uveitis due to intraocular filariasis treated with corticosteroids and antifilarial drugs (diethylcarbamazine, albendazole, and doxycycline) to prevent recurrences. Also, cataract extraction with intraocular lens implantation performed under steroid cover did not increase the postoperative uveitis in this patient and resulted in quicker visual rehabilitation.

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Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases

Abstract: In the WHO classification, subcutaneous panniculitis-like T-cell lymphoma (SPTL) is defined as a distinct type of T-cell

Cited by 598 publications

References 32 publications

Bone marrow involvement by subcutaneous Panniculitis-like T-cell lymphoma: a report of three cases

Bone marrow involvement by subcutaneous Panniculitis-like T-cell lymphoma: a report of three cases

Subcutaneous Panniculitis- like T-Cell Lymphoma: Report of two cases

Cutaneous γδ T-Cell Lymphoma With Bilateral Ocular and Adnexal Involvement

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