Subcutaneous panniculitis-like T-cell lymphoma: a clinicopathological, immunophenotypic and molecular analysis of six patients

Hoque, Shadiqul; Child, Fiona; Whittaker, Sean; Ferreira, S.V.; Orchard, Guy; Jenner, K; Spittle, Margaret F.; Russell‐Jones, Robin

doi:10.1046/j.1365-2133.2003.05226.x

Cited by 146 publications

(140 citation statements)

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“…In general, for indolent local disease, local radiotherapy can be used as an effective treatment modality [3,10,13,18,27,28]. For indolent disease with a more generalized distribution, immunosuppressive agents such as prednisone and cyclosporine, or systemic biologic agents, such as bexarotene and interferon, as well as low-dose chemotherapy with agents such as methotrexate may be used.…”

Section: Discussionmentioning

confidence: 99%

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Subcutaneous Panniculitis-like T-cell Lymphoma: Review of Therapies

S¹,

Chaudhari²

2015

Intern Med

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Subcutaneous Panniculitis-like T-cell Lymphoma (SPTCL) is a rare subtype of cutaneous T-cell lymphoma derived from alpha/beta cytotoxic T-cells. It is known to follow an indolent course with a favorable prognosis. We review current therapies used to treat this rare entity in order to increase awareness about possible options. No standardized therapy for SPTL currently exists. Local radiotherapy for indolent local disease has been found successful. For indolent disease with a more generalized distribution, immunosuppressive agents as well as lowdose chemotherapy may be used. For aggressive presentations, combination chemotherapy, anthracycline-based regimens, fludarabine-based regimens, and rarely high-dose chemotherapy followed by hematopoietic stem cell transplant (SCT) with moderate success. By being aware of possible therapeutic options, a physician can recommend the most appropriate treatment for the individual.

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Section: Discussionmentioning

confidence: 99%

“…Atypical lymphocytic infiltrate with hyperchromatic nuclei are present and described as "rimming" individual adipocytes, although this is not specific. In the early stage, a heavy inflammatory infiltrate may predominate as the neoplastic infiltrates may lack significant atypia [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Subcutaneous Panniculitis-like T-cell Lymphoma: Review of Therapies

S¹,

Chaudhari²

2015

Intern Med

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“…The proliferated and infiltrated lymphocytes tend to surround individual adipocytes. This is the characteristic rimming of fat spaces (6,9) There have been few case reports describing the US, CT or MR imaging as applied to peripheral T-cell lymphoma (4, 5, 10, 11). In these articles, the sonographic findings of subcutaneous panniculitis-like T-cell lymphoma showed poorly defined, homogeneous hyperechogenicity in the subcutaneous fat layer (5, 10, 11).…”

Section: Discussionmentioning

confidence: 99%

MR Findings of Subcutaneous Panniculitis-like T-Cell Lymphoma: A Case Report

Kim¹,

Kim

Kim³

et al. 2007

J Korean Radiol Soc

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Peripheral T-cell lymphoma (PTCL) has recently been described as a pathologic entity by the World Health Organization classification system for lymphoid neoplasms, and PTCL represents a relatively small proportion of all the lymphomas (1). It has a lower prevalence in Western countries than else where; it makes up approximately 10 15% of all non-Hodgkin's lymphomas in Europe (2), versus 25% in Korea (3). Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is an unusual type of PTCL. Clinically, it is often confused with inflammatory panniculitis. The medical literature contains little information on the diagnostic images of SPTCL, and especially the MR images. To the best of our knowledge, there are only a few reports on PTCL in the English-language medical literature (4, 5)We report here on the MR findings in a case of SPTCL that presented with a popliteal mass. Case ReportA 65-year-old female presented with 1-month history of a left popliteal mass. A 5 3 cm sized hard mass was palpated on the physical examination. The mass was mildly tender and had localized warmth. No evidence of peripheral lymphadenopathy or hepatosplenomegaly was found. Laboratory tests were performed; the WBC count was slightly increased (10290) but the other tests were unremarkable. MR imaging of the left knee was performed on a 1.5 T unit (Magnetom Vision, Simens Medical Systems, Iselin, NJ, U.S.A.) with using a knee coil. MR imaging of her left knee included the precontrast T1 weighted sagittal and coronal images, the fat suppressed proton density sagittal images, the T2 weighted axial and coronal images, and the fat suppressed T1 weighted axial and sagittal images after contrast injection. The mass was located in the subcutaneous layer of the popliteal fossa. It mea- Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare cancer and it is widely regarded as being distinct from the other subtypes of peripheral T-cell lymphoma. SPTCL commonly presents with subcutaneous nodules that resembles panniculitis. The clinicopathologic features of SPTCL have recently been described. However, only a few cases with their CT and sonographic findings have been reported in the radiologic literature. We illustrate here the MR findings of this rare tumor in one case that presented with a popliteal mass.

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“…[2][3][4][5] Misdiagnosis is not uncommon owing to the indolent course of the disease, which can mimic an unspecific panniculitis. 6 In our report three biopsies and 6 months were required before the final diagnosis could be made, by which time the lymphoma had become aggressive.…”

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confidence: 99%

“…6,7 Reports in the literature describe remission with schedules such as CHOP and FMD. 2,3 However, our patient progressed in the third week after MEGACHOD and, although an initial response to FMD was observed, early progression occurred.…”

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confidence: 99%