Subcutaneous nocardial abscess in a post-renal transplant patient

Devi, K. Rekha; Singh, Longjam Nilachandra; Devi, N. U.; Ns, Singh

doi:10.4103/0255-0857.34776

Cited by 7 publications

(3 citation statements)

References 9 publications

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“…Thus, each case needs a careful multidisciplinary evaluation by the primary physician, the infectious diseases specialist, and the surgeon. Mycetoma, some ocular infections, and rare cases with other body sites involvement may require surgical treatment [37,[65][66][67][68][69].…”

Section: Treatmentmentioning

confidence: 99%

Nocardiosis: Updated Clinical Review and Experience at a Tertiary Center

2010

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Nocardiosis is a rare opportunistic disease that affects mainly patients with deficient cell-mediated immunity, such as those with acquired immunodeficiency syndrome (AIDS) or transplant recipients. Pulmonary disease is the most common presentation in immunosuppressed patients and approximately one-third have a disseminated disease. Primary cutaneous nocardiosis is more frequently observed in immunocompetent patients with direct inoculation of the organism through professional exposure. The diagnosis can be challenging, as signs and symptoms are not specific and a high index of clinical of suspicion is necessary. Although gram stain, modified acid-fast stain, and cultures remain as the standard diagnostic tools, novel molecular techniques have changed the taxonomy of these organisms and, in some instances, have facilitated their identification. The disease has a marked tendency to recur and a high morbidity and mortality rate in immunosuppressed patients. Treatment is usually prolonged and an associated antibiotic treatment is preferred for severe disease. Although sulfonamides in combination with other antibiotics are still the treatment of choice, other associations such as imipenem plus amikacin are preferred in some centers. Linezolid is a useful alternative therapeutic agent due to its oral availability and activity against most of the isolates studied. Twenty-eight cases of nocardiosis were diagnosed at our center between January 1989 and April 2009. We report the epidemiologic characteristics of Nocardia spp. observed in our institution and discuss the risk factors, clinical features, diagnosis, and management of the disease.

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Section: Treatmentmentioning

confidence: 99%

Nocardiosis: Updated Clinical Review and Experience at a Tertiary Center

2010

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“…Devi et al reported the first case from eastern India of nocardiosis in a renal transplant patient presenting as subcutaneous abscess. 5 The lack of clinical data and consequent underreporting of nocardiosis is believed to be due to various factors. These include difficulty in disease diagnosis due to unfamiliarity with the disease, non-specific or lack of pathognomonic clinical presentation, presence of common and easily diagnosed co-infections that preclude further work-up for nocardiosis.…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of disseminated nocardiosis in a renal transplant recipient

Hooda

Nandwani

Kaur³

et al. 2013

Medical Journal Armed Forces India

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“…Talaromyces marneffei is a thermally dimorphic fungus that causes the opportunistic infection, talaromycosis, mostly in immunocompromised patients such as individuals with leukemia, neutropenia, auto-interferon gamma autoantibodies, and AIDS. In fact, in T. marneffei endemic areas, infection is very common and has been recognized as a disease indicative of AIDS ( Supparatpinyo et al., 1994 ; Supparatpinyo and Sirisanthana, 1994 ; Devi et al., 2007 ). There are over an estimated 8,000 cases of life-threatening T. marneffei infections annually with mortality rates of 2-75% ( Pal, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Antibody screening reveals antigenic proteins involved in Talaromyces marneffei and human interaction

Wangsanut

Amsri

Pongpom

2023

Front. Cell. Infect. Microbiol.

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Talaromycosis is a fungal infection that generally affects immunocompromised hosts and is one of the most frequent systemic mycoses in HIV patients, especially in endemic areas such as Southeast Asia. Talaromyces marneffei, the causative agent of talaromycosis, grows as a mold in the environment but adapts to the human body and host niches by transitioning from conidia to yeast-like cells. Knowledge of the human host and T. marneffei interaction has a direct impact on the diagnosis, yet studies are still lacking. The morbidity and mortality rates are high in taloromycosis patients if the diagnosis and treatments are delayed. Immunogenic proteins are excellent candidates for developing detection tools. Previously, we identified antigenic proteins that were recognized by antibodies from talaromycosis sera. Three of these identified proteins have been previously characterized in detail, while the others have not been explored. To expedite the progress of antigen discovery, the complete list of antigenic proteins and their features was fully reported in this study. Functional annotation and Gene Ontology examination revealed that these proteins showed a high association with membrane trafficking. Further bioinformatics analyses were performed to search for antigenic protein characteristics, including functional domains, critical residues, subcellular localization, secretory signals, and epitope peptide sequences. Expression profiling of these antigenic encoding genes was investigated using quantitative real-time PCR. The results demonstrated that most genes were expressed at low levels in the mold form, but were highly upregulated in the pathogenic yeast phase, consistent with the antigenic role of these genes during the human-host interaction. Most transcripts accumulated in the conidia, suggesting a role during phase transition. The collection of all antigen-encoding DNA sequences described here is freely accessible at GenBank, which could be useful for the research community to develop into biomarkers, diagnostic tests, research detection tools, and even vaccines.

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Subcutaneous nocardial abscess in a post-renal transplant patient

Cited by 7 publications

References 9 publications

Nocardiosis: Updated Clinical Review and Experience at a Tertiary Center

Nocardiosis: Updated Clinical Review and Experience at a Tertiary Center

Successful treatment of disseminated nocardiosis in a renal transplant recipient

Antibody screening reveals antigenic proteins involved in Talaromyces marneffei and human interaction

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