Subcutaneous nerve activity is more accurate than heart rate variability in estimating cardiac sympathetic tone in ambulatory dogs with myocardial infarction

Chan, Yi‐Hsin; Tsai, Wei Chung; Shen, Changyu; Han, Seongwook; Chen, Lan S.; Lin, Shien‐Fong; Chen, Peng Sheng

doi:10.1016/j.hrthm.2015.03.025

Cited by 22 publications

(19 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…8–10 In addition, SCNA is more effective than heart rate variability in estimating the sympathetic tone. 11 Encouraged by these results, we 12 showed that it is possible to simultaneously record electrocardiogram (ECG) and SKNA using conventional ECG electrodes in humans. The same electrical signal can be filtered between 0.5 Hz and 150 Hz to display ECG, while high pass filtered at 200 Hz or higher to display SKNA.…”

Section: Introductionmentioning

confidence: 95%

Skin sympathetic nerve activity precedes the onset and termination of paroxysmal atrial tachycardia and fibrillation

et al. 2017

Self Cite

View full text Add to dashboard Cite

Background Skin sympathetic nerve activity (SKNA) is useful in estimating sympathetic tone in humans Objective To test the hypothesis that (1) increased SKNA is associated with the onset and termination of paroxysmal atrial tachycardia (AT) and AF and (2) The sinoatrial node (SAN) response to SKNA is reduced in patients with more frequent of AT or AF. Methods SKNA and electrocardiogram were recorded in 11 patients (4 males and 7 females, average age 66±10 years), including 3 patients with AT (11±18 episodes/patient) and 8 patients with AF (24±26 episodes/patient). Results The average SKNA (aSKNA, in μV) 10 s prior to AT onset were 1.07±0.10; 10 s after termination were 1.27±0.10, both were significantly (p=0.032, p<0.0001) higher than that during sinus rhythm (0.97±0.09). The aSKNA 10 s prior to AF onset were 1.34±0.07 and 10 s after termination were 1.31±0.07. Both were significantly (p<0.0001) higher than that during sinus rhythm (1.04±0.07). The aSKNA before onset (p<0.0001) and after termination (p= 0.0011) were both higher in AF than in AT. The sinus rate correlated (p<0.0001) with aSKNA in each patient (average r: 0.74, 95% confidence interval (CI): 0.65–0.84). The r in each patient negatively correlated with the number of AT and AF episodes (r= − 0.6493, 95% confidence interval: −0.8990 to −0.08073, p=0.0306). Conclusions Increased SKNA was observed both at onset and termination of AT and AF. The patients with more frequent AT and AF episodes had less of a correlation between sinus rate and aSKNA, suggesting SAN remodeling by tachycardia.

show abstract

Section: Introductionmentioning

confidence: 95%

Skin sympathetic nerve activity precedes the onset and termination of paroxysmal atrial tachycardia and fibrillation

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…None of the above comparisons were statistically significant. These findings might be partially explained by our previous study 11 which showed that HRV parameters poorly correlates with SGNA in ambulatory dogs.…”

Section: Resultsmentioning

confidence: 84%

Effects of renal sympathetic denervation on the stellate ganglion and brain stem in dogs

et al. 2017

Self Cite

View full text Add to dashboard Cite

Background Renal sympathetic denervation (RD) is a promising method of neuromodulation for the management of cardiac arrhythmia. Objective We tested the hypothesis that RD is antiarrhythmic in ambulatory dogs because it reduces the stellate ganglion nerve activity (SGNA) by remodeling the stellate ganglion (SG) and brain stem. Methods We implanted a radiotransmitter to record SGNA and electrocardiogram in 9 ambulatory dogs for 2 weeks, followed by a 2nd surgery for RD and 2 months SGNA recording. Cell death was probed by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Results Integrated SGNA at baseline, 1 and 2 months after RD were 14.0±4.0, 9.3±2.8 and 9.6±2.0 μV, respectively (p=0.042). The SG from RD but not normal control (N=5) dogs showed confluent damage. An average of 41±10% and 40±16% of ganglion cells in the left and right SG, respectively, were TUNEL-positive in RD dogs compared with 0% in controls dogs (p= 0.005 for both). Left and right SG from RD dogs had more tyrosine hydroxylase-negative ganglion cells than left SG of control dogs (p= 0.028 and 0.047 respectively). Extensive TUNEL positive neurons and glial cells were also noted in the medulla, associated with strongly positive glial fibrillary acidic protein staining. The distribution was heterogeneous, with more cell death in the medial than lateral aspects of the medulla. Conclusion Bilateral RD caused significant central and peripheral sympathetic nerve remodeling and reduced SGNA in ambulatory dogs. These findings may in part explain the antiarrhythmic effects of RD.

show abstract

“…Extra-cardiac sympathetic neurons are located across numerous thoracic ganglia in particular in the stellate, middle cervical, superior cervical and mediastinal ganglia (Janes et al, 1986;Ardell and Armour, 2016). The electrophysiological properties of neurons located within the stellate ganglion and postganglionic axons traveling along the cardiac sympathetic nerve (CSN) have been studied extensively in several animal models in vivo, including ambulatory cats (Tsuchimochi et al, 2002), dogs (Han et al, 2012;Chan et al, 2015) sheep (Jardine et al, 2002(Jardine et al, , 2005(Jardine et al, , 2007Charles et al, 2018) and anesthetized cats (Nishikawa et al, 1994). Experiments conducted in conscious and anesthetized cats with either intact or denervated baroreceptors have been the model of choice to study periodic oscillations in CSNA.…”

Section: Lf Oscillations In Cardiac Sympathetic Postganglionic Fibersmentioning

confidence: 99%

Low-Frequency Oscillations in Cardiac Sympathetic Neuronal Activity

Ang

Marina

2020

Front. Physiol.

View full text Add to dashboard Cite

Sudden cardiac death caused by ventricular arrhythmias is among the leading causes of mortality, with approximately half of all deaths attributed to heart disease worldwide. Periodic repolarization dynamics (PRD) is a novel marker of repolarization instability and strong predictor of death in patients post-myocardial infarction that is believed to occur in association with low-frequency oscillations in sympathetic nerve activity. However, this hypothesis is based on associations of PRD with indices of sympathetic activity that are not directly linked to cardiac function, such as muscle vasoconstrictor activity and the variability of cardiovascular autospectra. In this review article, we critically evaluate existing scientific evidence obtained primarily in experimental animal models, with the aim of identifying the neuronal networks responsible for the generation of low-frequency sympathetic rhythms along the neurocardiac axis. We discuss the functional significance of rhythmic sympathetic activity on neurotransmission efficacy and explore its role in the pathogenesis of ventricular repolarization instability. Most importantly, we discuss important gaps in our knowledge that require further investigation in order to confirm the hypothesis that low frequency cardiac sympathetic oscillations play a causative role in the generation of PRD.

show abstract

Subcutaneous nerve activity is more accurate than heart rate variability in estimating cardiac sympathetic tone in ambulatory dogs with myocardial infarction

Cited by 22 publications

References 23 publications

Skin sympathetic nerve activity precedes the onset and termination of paroxysmal atrial tachycardia and fibrillation

Skin sympathetic nerve activity precedes the onset and termination of paroxysmal atrial tachycardia and fibrillation

Effects of renal sympathetic denervation on the stellate ganglion and brain stem in dogs

Low-Frequency Oscillations in Cardiac Sympathetic Neuronal Activity

Contact Info

Product

Resources

About