Subcutaneous mastectomy data: A final statistical analysis of 1500 patients

Pennisi, Vincent R.; Capozzi, Angelo

doi:10.1007/bf01570320

Cited by 129 publications

(40 citation statements)

References 13 publications

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“…At a median follow-up of 14 years, the incidence of new breast cancers was only 1.1%, representing a 91% reduction in risk when compared with female siblings who had not undergone prophylactic mastectomy. Similarly, Ziegler & Kroll (1991), re-analyzing data originally reported by Pennisi & Capozzi (1989), found an incidence of 1.2% in 510 high-risk patients who had undergone prophylactic mastectomy.…”

Section: Prophylactic Mastectomymentioning

confidence: 87%

“…Subcutaneous mastectomy has been particularly criticized because of the possibility of leaving tissue at the undersurface of the NAC. Although most large-scale studies have reported successful results from subcutaneous www.endocrinology.org 279 mastectomy (Pennisi & Capozzi 1989, Hartmann et al 1999, total mastectomy is considered to be the more definitive procedure.…”

Section: Prophylactic Mastectomymentioning

confidence: 99%

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New approaches to surgery for breast cancer.

Singletary¹

2001

Endocrine-Related Cancer

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The surgical management of breast cancer is rapidly evolving towards less invasive procedures. Alternative biopsy techniques, including fine-needle aspiration and core needle biopsy, are replacing excisional biopsy as the treatment standard. Breast conservation therapy is now widely used in place of mastectomy, both for small tumors and for larger tumors that have been downstaged through induction chemotherapy. Less invasive procedures for axillary treatment such as lymphatic mapping and sentinel lymph-node biopsy are being explored in an effort to avoid the morbidity associated with axillary lymph-node dissection. For women who still prefer or need to receive a mastectomy, immediate breast reconstruction with autologous tissue provides an excellent cosmetic outcome that is oncologically sound. This is especially appealing to high-risk women who opt to have a prophylactic mastectomy. High-risk women are also being offered the option of receiving chemopreventive treatment that may reduce their lifetime risk of cancer by almost 50%. These new, less invasive approaches require the close cooperation of a team of physicians, including surgeons, pathologists, radiologists, and medical and radiation oncologists.

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Section: Prophylactic Mastectomymentioning

confidence: 87%

Section: Prophylactic Mastectomymentioning

confidence: 99%

New approaches to surgery for breast cancer.

Singletary¹

2001

Endocrine-Related Cancer

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“…olarak sıralanabilir (2). BRCA1 ve 2 analizleri sayesinde yüksek risk taşıdığı tespit edilen hastalarda bilateral profilaktik mastektominin meme kanseri gelişme riskini yaklaşık %90 düşürdüğü (3); yaşam beklentisinin 2,9'dan 5.3 yıla çıktığı birçok çalışma tarafından gösterilmiştir (4 …”

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Profilaktik Mastektomide Meme Rekonstrüksiyonu

Serel¹,

Alpat²,

Çerkez³

et al. 2013

Ankara Üniversitesi Tıp Fakültesi Mecmuası

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Kadınlarda morbidite ve mortalite nedenlerinden bașı çeken meme kanserinin; artan toplumsal bilinç, BRCA1 ve BRCA2 gen mutasyon analizlerinin hız kazanması ve risk azaltıcı stratejilerin geliștirilmesiyle bazı olgularda önlenebilir olduğu netlik kazanmıștır. Yüksek risk tașıdığı tespit edilen bu hastalarda risk azaltıcı tekniklerden profilaktik mastektominin bilateral uygulandığı olgularda meme kanseri gelișme riskini yaklașık %85-90 düșürdüğü gösterilmiștir.Gelișen gen analizleri ile erken yașta tespit edilen ve vücut görünümünün bütünlüğüne önem veren yüksek riskli bu populasyonun profilaktik mastektomi sonrasında meme rekonstrüksiyonu isteği giderek artmaktadır. Ancak profilaktik mastektomi sonrası meme rekonstrüksiyonu bazı özellikler tașımaktadır. Bu nedenle hastalar multidisipliner bir yöntemle incelenmeli; cerrahi ișlemin zamanlaması, uygulanacak mastektomi tipi, (her hasta için kișiselleștirilmiș) rekonstrüksiyon seçenekleri, olușabilecek komplikasyonlar ameliyat öncesi ayrıntılarıyla konușulmalıdır. Bu çalıșmada profilaktik mastektomi sonrası rekonstrüksiyonunun önemi ve farklılıkları açıklanmıștır.Anahtar Sözcükler: Meme kanseri, BRCA 1-2, Profilaktik, Mastektomi, Meme rekonstrüksiyonu, İmplant, Otolog It has become evident that breast cancer; the leading cause of morbidity and mortality in women; can be prevented in some cases due to the increasing social awareness, BRCA1 and BRCA2 gene mutation analysis and developing risk reduction strategies. Prophylactic mastectomy, which happens to be one of those strategies, is found to reduce the risk of cancer development by 85-90 % in high-risk patients. Analysis of the genes leaves the surgeons with a population at an early age that gives importance to the integrity of the body image and demands breast reconstruction as soon as possible. However; breast reconstruction after prophylactic mastectomy bears some distinct features. For this reason, a multidisciplinary approach should be followed and the timing of surgical procedure, type of mastectomy to be applied, reconstruction options for each patient, possible complications should be discussed in details before the surgery. This study defines the differences and the importance of reconstruction after prophylactic mastectomy.

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“…8,9 The actual risk reduction that is provided by prophylactic mastectomy is presumed to be substantial but cannot be precisely measured due to uncertainty of pre-treatment risk, variable indications, and incomplete follow-up. 10 Even if risk reduction could be quantified, medical, cultural and financial issues make this approach unfeasible in clinical practice for most women.…”

Section: Prophylactic Mastectomymentioning

confidence: 99%

Can Breast Cancer be Prevented?

Stuart

1998

Ann Saudi Med

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RK Stuart, Can Breast Cancer be Prevented? 1998; 18(5): 385-388 Despite recent medical progress in the treatment of breast cancer, one-third of newly diagnosed patients receiving optimal medical management will ultimately die of the disease. And although treatment advances have also reduced the morbidity of breast cancer surgery, many women, especially in developing countries, still have reason to fear that breast cancer therapy will leave them disfigured. These limitations of treatment have encouraged a new focus on breast cancer prevention. Primary and Secondary PreventionThe evidence is compelling that a woman can take steps to reduce her risk of dying from breast cancer. Utilizing mammography with or without clinical breast examination, regular screening of women aged 50-69 years leads to a reduction in breast cancer mortality of 25%-30% at 10-12 years after initiation of screening.1 Women in the age range of 40-49 years may also benefit from screening, but the estimated effect is smaller, a 17% reduction in mortality at 15 years from the start of screening.2 These are examples of secondary prevention-early detection reduces the mortality and morbidity of breast cancer but not the incidence of the disease. True primary prevention of breast cancer requires a reduction in risk of developing breast cancer in the first place.The concept that breast cancer can be prevented is supported by the wide geographical variability in breast cancer rates and by migration studies that suggest environmental and/or lifestyle determinants of breast cancer risk. For instance, breast cancer rates are very low in Japan compared to North America, but descendants of Japanese immigrants to the USA acquire risk similar to that of North Americans within two generations. [3][4][5] In addition, many studies show support for a model of breast carcinogenesis in which an accumulation of multiple somatic mutations results in the final malignant phenotype. An appealing prediction of this model is that there are multiple steps in carcinogenesis where a preventive action could have a salutary effect.

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Subcutaneous mastectomy data: A final statistical analysis of 1500 patients

Cited by 129 publications

References 13 publications

New approaches to surgery for breast cancer.

New approaches to surgery for breast cancer.

Profilaktik Mastektomide Meme Rekonstrüksiyonu

Can Breast Cancer be Prevented?

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