Subcutaneous kerosene toxicity in albino rats

Rao, G. Sasibhushana; Kannan, K.; Goel, Sudhir K.; Pandya, K. P.; Shanker, Ravi

doi:10.1016/0013-9351(84)90158-0

Cited by 19 publications

(11 citation statements)

References 29 publications

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“…In studies conducted by Rao et al [58], where subcutaneous kerosene toxicity in albino rats was investigated, histopathological examination of the liver and other organs revealed treatmentrelated lesions. Additionally, biochemical indices studied to evaluate liver toxicity revealed an increase in alkaline phosphatase (ALP) and a decrease in benzo[a]pyrene hydroxylase (BAPH) levels.…”

Section: A N U S C R I P Tmentioning

confidence: 99%

“…Nonetheless, several studies have shown that high testosterone levels may predispose individuals to aggressive tendencies [57]. In a separate study earlier, conducted by Rao et al [58], histopathological examination of the adrenal gland, a member of the endocrine system, revealed lesions in male rats subcutaneously exposed to kerosene.…”

Section: Neuro-endocrine System Effectsmentioning

confidence: 99%

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Effects and mechanisms of kerosene use-related toxicity

Maiyoh¹,

Njoroge²,

Tuei³

2015

Environmental Toxicology and Pharmacology

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Section: A N U S C R I P Tmentioning

confidence: 99%

Section: Neuro-endocrine System Effectsmentioning

confidence: 99%

Effects and mechanisms of kerosene use-related toxicity

Maiyoh¹,

Njoroge²,

Tuei³

2015

Environmental Toxicology and Pharmacology

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“…There are few studies reporting kerosene levels following dermal exposure [10] and no studies on the distribution of kerosene in tissues, although toxicity through dermal exposure has been evaluated in humans [11,12,13,14] and in animal experiments [15,16,17].…”

Section: Introductionmentioning

confidence: 99%

Distribution of kerosene components in rats following dermal exposure

et al. 2002

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The systemic distribution of kerosene components in blood and tissues was analysed in rats following dermal exposure. Four types of trimethylbenzenes (TMBs) and aliphatic hydrocarbons (AHCs) with carbon numbers 9-16 (C(9)-C(16)) were analysed as major kerosene components by capillary gas chromatography/mass spectrometry (GC/MS). The kerosene components were detected in blood and all tissues after a small piece of cotton soaked with kerosene was applied to the abdominal skin. The amounts of TMBs detected were higher than those of AHCs. Greater increases in TMB levels were found in adipose tissue in an exposure duration-dependent manner. The amounts of TMBs detected were only at trace levels following post-mortem dermal exposure to kerosene. These findings suggest that kerosene components were absorbed percutaneously and distributed to various organs via the blood circulation. Post-mortem or ante-mortem exposure to kerosene could be distinguished when the exposure duration was relatively long. Adipose tissue would seem to be the most useful for estimating the degree of kerosene exposure.

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“…In animal models, the systemic effects of JP-8 are often broad, consistently substantial, and statistically significant. Studies that examined the effect of exposure to petroleum middle distillates (e.g., kerosene, the major constituent of jet fuel) have documented reversible variation in hematologic profile, significant decreases in relative weight of thymus, spleen, and abdominal lymph nodes and altered histology [3] as well as liver, spleen, thymus, kidney, adrenal, and lymph node lesions [4], and subacute inflammation and nongenotoxic tumorigenicity in mice [5,6]. We recently reported significant alterations in the pattern of protein expression in mouse lung tissue in response to aerosolized JP-8 jet fuel exposure under simulated occupational conditions [7].…”

Section: Introductionmentioning

confidence: 99%