Subcutaneous interferon alpha 2a combined with cryotherapy vs cryotherapy alone in the treatment of primary anogenital warts: a randomised observer blind placebo controlled study.

Handley, J.; Hörner, Thomas; Maw, R D; Lawther, H; Dinsmore, W W

doi:10.1136/sti.67.4.297

Cited by 30 publications

(22 citation statements)

References 37 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The recurrence rate in the IFNtreated patient group was significantly lower compared to that seen in the group receiving placebo. No significant difference in tolerance, however, was noted between cycli cally administered rIFN-a?a at low dose (l million IU per day injection) and placebo [57], The results obtained in this study with the cyclic rIFN-a?a treatment regimen was more effective than results observed in previous studies where a continuous IFN-a?a treatment was used [51,52,55,56,58,59].…”

Section: Adjuvant Interferon Therapycontrasting

confidence: 62%

Therapy of Human Papillomavirus Infection and Associated Epithelial Tumors

Gross

1997

Intervirology

View full text Add to dashboard Cite

Papillomavirus infections are very common and cause various benign and malignant lesions, most notably condyloma acuminatum, anogenital cancer, laryngeal papilloma and skin warts. Unfortunately, effective therapy is currently not available. Therapeutic options are limited, expensive and often ineffective. They comprise cytodestructive and cytotoxic substances, surgical methods, laser and cryotherapy. Immunotherapy seems to be one of the more promising options. Interferons combined with ablative methods such as CO2 laser can prevent recurrence of disease. Cytokine enhancement is an old concept that has shown effectiveness with imidazoquinolinamine derivatives (imiquimod). Imiquimod was released recently for therapy of genital warts. Currently, HPV vaccines are being developed to protect against infection with HPV and to treat existing warts and other HPV-associated lesions. Some processes in the HPV infection cycle have been determined as possible targets for the development of specific antiviral agents. Cidofovir is a primordial antiviral substance active against HPV. Unfortunately, there is a potential risk for side effects.

show abstract

Section: Adjuvant Interferon Therapycontrasting

confidence: 62%

Therapy of Human Papillomavirus Infection and Associated Epithelial Tumors

Gross

1997

Intervirology

View full text Add to dashboard Cite

show abstract

“…7 Likewise, excisional biopsy by scissors may result in scarring and dyspigmentation, 11 and cryotherapy may cause postablative cutaneous blistering, ulceration, edema, and hypopigmentation in colored skin. [12][13][14] Moreover, it is not recommended for large lesion areas. 15 Other problems of electrosurgery include intraoperative adhesions between tissue and the ablating device as well as obstructed visibility within the anal canal caused by smoke plume formation, 15 increasing the risk of uncontrolled tissue damage.…”

Section: Discussionmentioning

confidence: 99%

Ultrasonic Technology: A New Treatment Option for Anal Condylomata Acuminata

Colombo-Benkmann¹,

Tübergen²,

Buchweitz³

et al. 2008

Diseases of the Colon &Amp; Rectum

View full text Add to dashboard Cite

show abstract

“…Its advantage compared to an intralesional application is the absence of pain and frequent visits to physicians. 51 Handley 52 and Eron 53 each compare cryotherapy plus IFN injection versus cryotherapy plus placebo. Intralesional IFNα is injected directly into the base of each wart.…”

Section: Interferonsmentioning

confidence: 99%

“…Data show no clear advantage of using subcutaneous interlesional interferon over cryotherapy alone. 52,53 It is very interesting that Interferon does not have always a synergistic effect with other treatment modalities in the treatment of condyloma. 54 Subcutaneous IFNα2a combined with cryotherapy was no more effective than cryotherapy alone in the treatment of primary anogential warts.…”

Section: Interferonsmentioning

confidence: 99%

“…55 Similarly, IFNα2a in combination with podophyllin was no more effective in the treatment of primary anogenital warts than podophyllin alone and is associated with more adverse events. 52 However, combining Interferon with other treatments increases the likelihood of effective treatment. The additional application of subcutaneously administered interferon α-2b to laser treated patients with chronic therapy-resistant genital lesions significantly enhanced the chance of eliminating these warts.…”

Section: Interferonsmentioning

confidence: 99%

See 1 more Smart Citation

Sexually transmitted papillomavirus infections: epidemiology pathogenesis, clinic, morphology, important differential diagnostic aspects, current diagnostic and treatment options

Tchernev¹

2009

An. Bras. Dermatol.

View full text Add to dashboard Cite

The family of human papilloma viruses (HPV) comprises more than 100 genotypes. Approximately 30 of the genotypes are responsible for infections in the human anogenital area. A precisely defined algorithm with the goal of diagnosing and removing HPV for a prolonged or indefinite length of time, as well as to protect the patient from any malignant ransformation, does not currently exist. The identification of HPV strains by PCR or DNA hybridization in lesional tissue provides higher security for the patients. In high-risk patients additional colposcopy, rectoscopy, and rethroscopy/cystoscopy increase the probability of proper diagnosis and the application of a reliable therapeutic strategy. Removal of lesions by means of invasive methods, such as electrodessication, cryosurgery, and/or laser therapy, may be successful and could be combined pre- and postoperatively with the local application of podophyllotoxin, Trichloroacetic acid, 5-fluorouracil epinephrine gel, imiquimod, cidofovir or interferon. The administration of vaccine to young patients prevents to a significant extent the clinical manifestation of the most frequent viral strains, being HPV-6,-11 and -18. The different therapeutic methods must be applied in accordance with the clinical picture, taking into account the patient's general status, the presence of concomitant diseases, as well as the local and systematic compatibility of the side effects of each remedy. The review focuses on the diagnosis and treatment options of sexually transmitted HPV-infections and includes synopsis of the most recent literature regarding new data of epidemiology, pathogenesis, ifferential diagnosis and morphology of HPV infections in humans.

show abstract

Subcutaneous interferon alpha 2a combined with cryotherapy vs cryotherapy alone in the treatment of primary anogenital warts: a randomised observer blind placebo controlled study.

Cited by 30 publications

References 37 publications

Therapy of Human Papillomavirus Infection and Associated Epithelial Tumors

Therapy of Human Papillomavirus Infection and Associated Epithelial Tumors

Ultrasonic Technology: A New Treatment Option for Anal Condylomata Acuminata

Sexually transmitted papillomavirus infections: epidemiology pathogenesis, clinic, morphology, important differential diagnostic aspects, current diagnostic and treatment options

Contact Info

Product

Resources

About