Subcutaneous Injection of Kisspeptin-54 Acutely Stimulates Gonadotropin Secretion in Women With Hypothalamic Amenorrhea, But Chronic Administration Causes Tachyphylaxis

Jayasena, Channa N.; Nijher, Gurjinder; Chaudhri, Owais B.; Murphy, Kevin G.; Ranger, Amita; Lim, Adrian; Patel, Darshan; Mehta, Amrish; Todd, Catriona; Ramachandran, Radha; Salem, Victoria; Stamp, Gordon; Donaldson, Mandy; Ghatei, Mohammad A.; Bloom, Stephen R.; Dhillo, Waljit

doi:10.1097/01.ogx.0000371721.87500.d0

Cited by 22 publications

(31 citation statements)

References 19 publications

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“…We have previously reported that delays in the onset of puberty in dexamethasone‐induced IUGR rats occur independently of the hypothalamic Kiss1‐gonadotropin‐releasing hormone (GnRH) system (Iwasa et al, 2011). Kisspeptin, a kiss1 gene product (Kotani et al, 2001; Ohtaki et al, 2001), stimulates GnRH release via kisspeptin receptor (kiss1r) (Irwig et al, 2004; Matsui et al, 2004; Shahab et al, 2005; Jayasena et al, 2009; Roseweir and Millar, 2009) and is a key factor for pubertal onset in humans, rodents and monkeys (de Roux et al, 2003; Funes et al, 2003; Seminara et al, 2003; Navarro et al, 2004; Shahab et al, 2005). To the best of our knowledge, no studies have described the influence of prepubertal exposure to glucocorticoids on body growth, onset of puberty and alterations in hypothalamic reproductive function, including the kisspeptin system, in rats.…”

Section: Introductionmentioning

confidence: 99%

Prepubertal exposure to glucocorticoid delays puberty independent of the hypothalamic Kiss1‐GnRH system in female rats

Kinouchi

Matsuzaki²,

Iwasa³

et al. 2012

Intl J of Devlp Neuroscience

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Secretion of glucocorticoids is widely known as a key endocrine response to stresses. Prenatal dexamethasone administration induces intrauterine growth retardation and delayed onset of puberty in female rats independent of the hypothalamic Kiss1-gonadotropin-releasing hormone (GnRH) system. The aim of this study was to evaluate the influence of chronic intracerebroventricular (central, CD) or subcutaneous (peripheral, PD) dexamethasone administration to prepubertal female rats on the onset of puberty and body weight change. Rats administered dexamethasone from day 25 to day 34 (CD and PD) showed significantly reduced body weight gain throughout the experimental period and delayed onset of vaginal opening compared with rats administered saline centrally (CS) or peripherally (PS). At 34 days old, hypothalamic Kiss1r mRNA levels were significantly lower with CD than with CS. No significant differences were seen between rats administered saline and rats administered dexamethasone with regard to hypothalamic Kiss1, GnRH and NPY mRNA levels or serum LH levels. Serum leptin concentrations were higher in CD and PD than in the controls (CS and PS). These results suggest that the delayed onset of puberty induced by prepubertal dexamethasone administration occurs independent of the hypothalamic Kiss1-GnRH system.

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Section: Introductionmentioning

confidence: 99%

Prepubertal exposure to glucocorticoid delays puberty independent of the hypothalamic Kiss1‐GnRH system in female rats

Kinouchi

Matsuzaki²,

Iwasa³

et al. 2012

Intl J of Devlp Neuroscience

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“…Subcutaneous injection of kisspeptin-54 in women with hypothalamic amenorrhea caused a potential increase in LH and FSH levels. is response becomes clear in the preovulatory phase [39][40][41].…”

Section: Discussionmentioning

confidence: 95%

The Correlation between Hormonal Disturbance in PCOS Women and Serum Level of Kisspeptin

Ibrahim

Omer

Fattah

2020

International Journal of Endocrinology

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Background. Kisspeptin is a neuropeptide that upregulates gonadotropin-releasing hormone (GnRH) secretion. It is an essential element for the luteinizing hormone (LH) surge and ovulation. Women with polycystic ovary syndrome (PCOS) expose alteration in both GnRH and LH secretion levels. Objective. This paper aims to evaluate serum kisspeptin levels in healthy and polycystic ovarian syndrome women. Furthermore, it investigates the effect of obesity and age on circulating kisspeptin levels in both normal and PCOS women. Moreover, it points out the correlation between kisspeptin and other hormonal parameters. Methods and Patients. One hundred women (60 are with PCOS and 40 are normal) were enrolled in the study. Five milliliter samples of blood from all the patients and control women were obtained twice during the menstrual cycle. All the study samples were classified depending on the age factor for several subgroups. Results. Kisspeptin levels were higher in PCOS patients than those in the normal group. Kisspeptin correlated with serum free testosterone level (r=0.26). In healthy women, preovulatory kisspeptin levels were higher than follicular kisspeptin levels (P<0.05), while this difference was insignificant in PCOS patients. The variation in serum kisspeptin levels between overweight/obese and normal-weight women was insignificant. In normal women, serum kisspeptin levels were higher in women >35 years than those <24 years at (P=0.03). Conclusion. The serum kisspeptin level is higher in PCOS women. Its levels fluctuate during the menstrual cycle, but these fluctuations are disturbed in PCOS women. The effect of BMI on serum kisspeptin levels is insignificant, and kisspeptin serum levels increase with age.

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“…Kp in functional hypothalamic amenorrhoea (HA) due to low body weight and found Kp effectively stimulated Gn's. This effect was marked following first injection but significantly diminished after 2 weeks of treatment [117]. However biweekly administration of Kp resulted in a sustained Gn response to Kp treatment [118], and that in women with HA, the LH response was four fold greater than that of healthy females.…”

Section: Prospective Therapeutic Roles I) Initially Jayasena Et Al Tmentioning

confidence: 92%

Kisspeptins in human reproduction—future therapeutic potential

Kaur¹,

Allahbadia

Singh³

2012

J Assist Reprod Genet

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Kps have proven as pivotal regulators of the reproduction, with the ability to integrate signals from both internal and external sources. Knowledge about signaling mechanisms involved in Kp stimulation of GnRH and with human studies has made it possible that therapeutically available Kp agonists/antagonists may be used for treatment of delayed puberty/HH, Hypothalamic amenorrhea and in prevention of spread of malignant ovarian/gonadal malignancies along with uses in some eating disorders.

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Subcutaneous Injection of Kisspeptin-54 Acutely Stimulates Gonadotropin Secretion in Women With Hypothalamic Amenorrhea, But Chronic Administration Causes Tachyphylaxis

Cited by 22 publications

References 19 publications

Prepubertal exposure to glucocorticoid delays puberty independent of the hypothalamic Kiss1‐GnRH system in female rats

Prepubertal exposure to glucocorticoid delays puberty independent of the hypothalamic Kiss1‐GnRH system in female rats

The Correlation between Hormonal Disturbance in PCOS Women and Serum Level of Kisspeptin

Kisspeptins in human reproduction—future therapeutic potential

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