Subcutaneous Infusion and Intramuscular Injection of Desferrioxamine in Patients With Transfusional Iron Overload

Hussain, M A; Green, N.; Flynn, Denis; Hussein, Sonay; Hoffbrand, A. V.

doi:10.1016/s0140-6736(76)92035-3

Cited by 100 publications

(32 citation statements)

References 7 publications

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“…Evidence that prognosis is improved by regular transfusions and iron chelation [6, 8, 9]has been available for more than 25 years. Our results show an encouraging trend in every country towards earlier diagnosis and treatment.…”

Section: Discussionmentioning

confidence: 99%

Impact of Thalassemia major on Patients and Their Families

Jaime

Ward²,

Green³

et al. 2002

Acta Haematol

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Objective: To describe the burden of thalassemia major and its treatment, in terms of prevalence of iron-overload-related complications, direct and indirect costs, and the patient’s physical and social well-being. Methods: From October 1999 to May 2000 a survey of patients with thalassemia major was conducted in ten countries: Cyprus, Egypt, Greece, Hong Kong, India, Iran, Italy, Jordan, Taiwan, and the United States. Results: 1,888 questionnaires (65%) were returned. The responses suggest that nowadays patients begin blood transfusions, and most use desferrioxamine (84.8%), but iron-related complications, including life-threatening ones such as heart disease, are still common. Conclusions: There remains a need to improve the management of thalassemia, as many patients with iron-related complications experience physical and social limitations.

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Section: Discussionmentioning

confidence: 99%

Impact of Thalassemia major on Patients and Their Families

Jaime

Ward²,

Green³

et al. 2002

Acta Haematol

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“…Six couples had already had normal children in ignorance of their risk before antenatal diagnosis was available (phase 1). The year in which they were informed of their risk and decided what to do about the current pregnancy was counted as phase 4, and subsequent years as phase 3. Eighteen mothers were primigravidae who had married after antenatal diagnosis became generally available (1976).…”

Section: Detection Of At-risk Couplesmentioning

confidence: 99%

Effect of introducing antenatal diagnosis on reproductive behaviour of families at risk for thalassaemia major.

Modell¹,

Ward²,

Fairweather³

1980

BMJ

108

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“…Iron-chelation therapy with desferrioxamine has become the standard treatment for most patients. 1,2 However, desferrioxamine has to be administered by s.c. or i.v. infusion for a prolonged period (8-12 h per day) regularly (4-7 times per week), which is cumbersome, difficult to comply with and painful.…”

Section: Introductionmentioning

confidence: 99%

Quality of life in patients with transfusion-dependent thalassemia after hematopoietic SCT

Cheuk

Mok

Lee

et al. 2008

Bone Marrow Transplant

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In this cross-sectional study, we compared the quality of life (QOL) in transfusion-dependent thalassemic patients who survived matched sibling hematopoietic SCT (HSCT, n ¼ 24) with patients treated conventionally with transfusion and iron chelation (n ¼ 74). WHOQOL-BREF(HK) and PedsQL questionnaires were administered to patients aged 418 years and 5-12 years, respectively. Patients aged 12-18 years received both questionnaires. WHOQOL-BREF(HK) revealed post transplant patients rated overall health better than those treated conventionally (score 3.67 vs 3.06, P ¼ 0.01). They are less dependent on medical aids (3.87 vs 2.96, P ¼ 0.006), having higher activity level (4.00 vs 3.36, P ¼ 0.026) and better personal relationships (4.13 vs 3.69, P ¼ 0.014). Physical health domain score was better (75.20 vs 63.94, P ¼ 0.007). These differences remained significant after adjustment for comorbidities. PedsQL revealed post transplant patients rated better for running (3.53 vs 2.72, P ¼ 0.001) and sports (3.20 vs 2.64, P ¼ 0.038), even after adjustment for comorbidities, but were less satisfied for school absence to attend hospital (2.53 vs 3.29, P ¼ 0.03). Post transplant patients were significantly more likely to consider marriage (100 vs 75.7%, P ¼ 0.033), but not childbearing (66.7 vs 51.4%, P ¼ 0.28). In conclusion, transplanted thalassemic patients enjoy better QOL, mainly in physical health, compared with conventionally treated patients. This information is important to patients considering HSCT.

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Subcutaneous Infusion and Intramuscular Injection of Desferrioxamine in Patients With Transfusional Iron Overload

Cited by 100 publications

References 7 publications

Impact of Thalassemia major on Patients and Their Families

Impact of Thalassemia major on Patients and Their Families

Effect of introducing antenatal diagnosis on reproductive behaviour of families at risk for thalassaemia major.

Quality of life in patients with transfusion-dependent thalassemia after hematopoietic SCT

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