Subcutaneous infiltration with ammonium sulphate 10% does not prolong the local anaesthetic duration of lidocaine in humans

Møiniche, S.; Dahl, Arve; Dahl, Jørgen B.

doi:10.1034/j.1399-6576.2000.440716.x

Cited by 3 publications

(2 citation statements)

References 19 publications

(42 reference statements)

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“…Unchanged skin surface temperature and blood flow suggest that the ineffectiveness of lidocaine was not due to changes in these parameters. Several previous reports showed conflicting results: subcutaneous lidocaine attenuated heat pain in mice (Womer and Shannon 2000;Sakaue et al 2004) and in human experiments (Møiniche et al 2000), but not in others (Graven-Nielsen et al 2004), and iontophoretically administered lidocaine did not blunt the heat pain threshold (Wallace et al 2001). These reports suggest that the cutaneous nerve fibers conducting pricking pain and heat pain are different from each other, or that the transduction mechanism of heat and mechanical stress is differently modified by surface anesthesia.…”

Section: Discussionmentioning

confidence: 89%

Influence of surface anesthesia on the pressure pain threshold measured with different-sized probes

Takahashi

Taguchi

Itoh

et al. 2005

Somatosensory & Motor Research

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Transcutaneous pressure with pressure probes of arbitrary diameters have been commonly used for measuring the threshold and magnitude of muscle pain, yet this procedure lacks scientific validation. To examine the valid probe dimensions, we conducted physiological experiments using 34 human subjects. Pin-prick pain, pressure pain threshold (PPT) to pressure probes of various diameters, heat pain threshold, and electrical pain threshold of deep tissues were measured before and after application of surface lidocaine anesthesia to the skin surface over the brachioradial muscle in a double-blinded manner. The anesthesia neither affected PPT with larger probes (diameters: 1.6 and 15 mm) nor increased electric pain threshold of deep structures, whereas it diminished pain count in pin-prick test and PPT with a 1.0 mm diameter probe, suggesting that mechanical pain thresholds measured with 1.6 and 15 mm probes reflect the pain threshold of deep tissues, possibly muscle. Pain thresholds to heat did not change after application of the anesthesia. These results suggest that larger pressure probes can give a better estimation of muscular pain threshold.

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Section: Discussionmentioning

confidence: 89%

Influence of surface anesthesia on the pressure pain threshold measured with different-sized probes

Takahashi

Taguchi

Itoh

et al. 2005

Somatosensory & Motor Research

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“…Therefore, a long-acting local anesthetic would improve the management of postoperatory pain, but no such agent is yet available for clinical use (Grant et al 2004). As a result, in the last few years, there has been an increased interest for developing a long-lasting local anesthesia that can be established by a single injection (Møiniche et al 2000;Grant 2002;Kohane et al 2003, Stevens et al 2004, Pedersen et al 2004.…”

Section: Introductionmentioning

confidence: 98%

Potentiation of Local Anesthetic Activity of Neosaxitoxin with Bupivacaine or Epinephrine: Development of a Long-Acting Pain Blocker

et al. 2009

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Local anesthetics effectively block and relieve pain, but with a relatively short duration of action, limiting its analgesic effectiveness. Therefore, a long-acting local anesthetic would improve the management of pain, but no such agent is yet available for clinical use. The aim of this study is to evaluate the potentiation of the anesthetic effect of neosaxitoxin, with bupivacaine or epinephrine in a randomized double-blind clinical trial. Ten healthy males were subcutaneously injected into the left and right forearms with a randomized pair of the following treatments: (i) bupivacaine (5 mg); (ii) neosaxitoxin (10 microg); (iii) neosaxitoxin (10 microg) plus bupivacaine (5 mg), and (iv) neosaxitoxin (10 microg) plus epinephrine (1:100.000), but all participant received all four formulations (in 2 ml; s.c.), with 1 month elapsing between the two round of experiments. A validated sensory and pain paradigm was used for evaluating the effect of the treatment 0-72 h after the injections, measuring sensory, pain, and mechanical touch perception threshold. The duration of the effect produced by combined treatments was longer than that by the single drugs. In conclusion, bupivacaine and epinephrine potentiate the local anesthetic effect of neosaxitoxin in humans when co-injected subcutaneously. The present results support the idea that neosaxitoxin is a new long-acting local pain blocker, with highly potential clinical use.

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The efficacy of injecting a distillate of the pitcher plant (Sarraceniaceae) adjacent to the palmar digital nerves of horses to ameliorate lameness caused by digital pain

Livesey,

DeGraves,

Allred

et al. 2024

Journal of Equine Veterinary Science

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Subcutaneous infiltration with ammonium sulphate 10% does not prolong the local anaesthetic duration of lidocaine in humans

Abstract: No improvement in local anaesthetic duration of ammonium sulphate 10% plus lidocaine 1% compared with lidocaine 1% alone was demonstrated early after subcutaneous infiltration in human volunteers.

Cited by 3 publications

References 19 publications

Influence of surface anesthesia on the pressure pain threshold measured with different-sized probes

Influence of surface anesthesia on the pressure pain threshold measured with different-sized probes

Potentiation of Local Anesthetic Activity of Neosaxitoxin with Bupivacaine or Epinephrine: Development of a Long-Acting Pain Blocker

The efficacy of injecting a distillate of the pitcher plant (Sarraceniaceae) adjacent to the palmar digital nerves of horses to ameliorate lameness caused by digital pain

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