Subcutaneous infection caused by Corynespora cassiicola, a plant pathogen

Huang, Hong-Kai; Liu, Chun-Eng; Liou, Jia-Hung; Hsiue, Emily Han‐Chung; Hsiao, Cheng–Hsiang; Hsueh, Po-Ren

doi:10.1016/j.jinf.2009.11.002

Cited by 33 publications

(32 citation statements)

References 8 publications

(3 reference statements)

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“…Interestingly, fungal osteomyelitis of the foot due to C. bantiana and Corynespora spp. represent rare fungal infections in this series (26)(27)(28).…”

Section: Discussionmentioning

confidence: 75%

Molecular and Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry-Based Characterization of Clinically Significant Melanized Fungi in India

Singh

Kumar

et al. 2017

J Clin Microbiol

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Melanized or black fungi are a heterogeneous group of fungi causing cutaneous to systemic diseases with high mortality. These fungi are rarely reported as agents of human infections, primarily due to difficulties in their classical identification. In this study, we examined, using molecular methods and matrix-assisted laser desorption ioniazation-time of flight mass spectrometry (MALDI-TOF MS), the diversity of melanized fungi (MF) isolated from patients in 19 medical centers in India. Overall, during a 4-year period, 718 (5.3%) clinical specimens yielded MF. Of these, 72 (10%) isolates had clinical significance and were identified primarily by sequencing the internal transcribed spacer and large subunit (LSU) regions. MF represented 21 genera comprising 29 species, the majority of them belonging to the orders Pleosporales (50%) and Chaetothyriales (22%). Among the 29 fungal species identified in this study, only 6 (20%) species were identified by the MALDI-TOF MS due to the limited commercial database of Bruker Daltonics for MF. However, a 100% identification rate of 20 additional species identified in this study was obtained by constructing an inhouse database using 24-to 96-h-old liquid cultures. Further, the CLSI broth microdilution method revealed low MICs for posaconazole (Յ1 g/ml) and voriconazole (Յ2 g/ml) in 96% and 95% of isolates, respectively. Skin/subcutaneous and sinonasal and pulmonary phaeohyphomycosis due to MF were diagnosed in 21.4% (n ϭ 15) and 28.5% (n ϭ 20) of cases. Also, 10% of patients had central nervous system involvement (n ϭ 7), and 3 cases of fungal osteomyelitis due to Cladophialophora bantiana and Corynespora spp. were observed.

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“…Interestingly, fungal osteomyelitis of the foot due to C. bantiana and Corynespora spp. represent rare fungal infections in this series (26)(27)(28).…”

Section: Discussionmentioning

confidence: 75%

Molecular and Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry-Based Characterization of Clinically Significant Melanized Fungi in India

Singh

Kumar

et al. 2017

J Clin Microbiol

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“…Phaeohyphomycosis is the general term used to describe infections caused by dematiaceous, or darkly pigmented, fungi. Corynespora cassiicola , a common plant pathogen, rarely causes human infections, and to the best of our knowledge there have been only four reported patients infected by C. cassiicola . The first case was reported as a mycetoma of the foot in an Ethiopian farmer .…”

Section: Discussionmentioning

confidence: 99%

CARD 9 mutation linked to Corynespora cassiicola infection in a Chinese patient

Yan

et al. 2015

Br J Dermatol

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Corynespora cassiicola is a plant pathogen associated with leaf-spotting disease. The fungus has been found on diverse substrates: leaves, stems and roots of plants; nematode cysts and human skin. It rarely causes human infections. Here we report one case of subcutaneous phaeohyphomycosis caused by C. cassiicola with prominent tissue necrosis in a woman. All of her clinical features pointed towards a genetic linkage. Hence, whole-exome sequencing and Sanger sequencing were performed on this patient. One mutation of CARD9 was detected.

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“…The first case was reported in 1969 [6], in which Corynespora cassiicola was isolated from a patient with Madura foot in the Sudan. Huang and his colleague described a farmer with subcutaneous infection in both hands caused by Corynespora cassiicola [7]. Another subcutaneous infection caused by Corynespora cassiicola was also reported afterwards [4].…”

Section: Discussionmentioning

confidence: 99%

“…For the treatment of Corynespora cassiicola infection, terbinafine [4] and amphotericin B [7] have also shown success. More specifically, the patient with corneal infection healed after receiving the treatment with topical voriconazole, micafungin and pimaricin for 3 months and intravenous voriconazole for 1 month [8].…”

Section: Discussionmentioning

confidence: 99%

“…More specifically, the patient with corneal infection healed after receiving the treatment with topical voriconazole, micafungin and pimaricin for 3 months and intravenous voriconazole for 1 month [8]. Subcutaneous infections in both hands were treated successfully with amphotericin B after ineffective oral itraconazole therapy [7]. And subcutaneous infections in the legs were cured with oral terbinafine and topical povidone iodine for 6 weeks [4].…”

Section: Discussionmentioning

confidence: 99%

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A case of Phaeohyphomycosis caused by Corynespora cassiicola infection

Xie

De-sheng

et al. 2018

BMC Infect Dis

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BackgroundCorynespora cassiicola infection is common in plants, but the human Corynespora cassiicola infection in our report is rare according to the literature.Case presentationWe report a case of subcutaneous phaeohyphomycosis caused by a plant pathogen in a patient with acute heart failure. The organism was isolated and identified as Corynespora cassiicola according to its morphological characteristics and gene analysis. The patient was treated successfully with systemic voriconazole.ConclusionsThis is the third reported case of subcutaneous infection caused by Corynespora cassiicola and the first reported case with accompanied renal impairment, which was associated with acute heart failure. Our case also suggests the importance of renal function monitoring in patients receiving intravenous voriconazole treatment.Electronic supplementary materialThe online version of this article (10.1186/s12879-018-3342-z) contains supplementary material, which is available to authorized users.

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Subcutaneous infection caused by Corynespora cassiicola, a plant pathogen

Cited by 33 publications

References 8 publications

Molecular and Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry-Based Characterization of Clinically Significant Melanized Fungi in India

Molecular and Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry-Based Characterization of Clinically Significant Melanized Fungi in India

CARD 9 mutation linked to Corynespora cassiicola infection in a Chinese patient

A case of Phaeohyphomycosis caused by Corynespora cassiicola infection

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