Subcutaneous hyalohyphomycosis caused byFusariumin a kidney transplant recipient

Abstract

Fusarium is a filamentous opportunistic pathogenic fungus responsible for superficial as well as invasive infection in immunocompromized hosts. Net state of immunosuppression and cytomegalovirus (CMV) infection appear to predispose to this disease which is life-threatening when disseminated. Though infections with Fusarium have been widely described in hematological malignancies and hematopoietic stem cell transplant cases, they have been reported to be rare in solid organ transplant recipients, are often localized and carry a favorable prognosis. We here describe a rare case of subcutaneous non-invasive infection with Fusarium in a renal allograft recipient two and half years after transplantation. Patient had a previous history of CMV infection along with multiple other recurrent co-infections. Diagnosis was based on culture of tissue specimens yielding Fusarium species. The infection had a protracted course with persistence of lesions after treatment with voriconazole alone, requiring a combination of complete surgical excision and therapy with the anti-fungal drug.

Hyalohyphomycosis in an orthopedic patient: case report.

“…However, it is important to understand that this disease manifests itself in other ways, such as cutaneous. In the literature there are cases of subcutaneous infection by hyalohyphomycosis that manifest as subcutaneous nodules in a kidney transplant recipient [6] and as abscesses in a patient with myasthenia gravis [7].…”

Isolated pulmonary fusariosis caused by Neocosmospora pseudensiformis in a liver transplant recipient: A case report and review of the literature

“…During 1979 to 2018, we identified 27 cases of fusariosis reported in solid organ transplantation 7‐28 (Table 2). Isolated pulmonary fusariosis is normally found in lung transplantation.…”