Subcutaneous gentamicin injection around the cuff in treatment of resistant exit site infection in peritoneal dialysis patients: a pilot study

Dizdar, Oğuzhan Sıtkı; Ozer, Ozerhan; Erdem, Selahattin; Günal, Ali İhsan

doi:10.2147/tcrm.s140894

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…Topical gentamicin effectively treats Nagashima-type disease [31] and topical and intradermal gentamicin suppresses dystrophic epidermolysis bullosa [32]. Subcutaneous injection of gentamicin effectively treats cutaneous infections in adult patients [33] and gentamicin effectively treats women with community-onset complicated and acute pyelonephritis [34]. Azithromycin and gentamicin treat brucellosis in 70% of patients [35].…”

Section: Discussionmentioning

confidence: 99%

“…Topical and intradermal gentamicin suppresses dystrophic epidermolysis bullosa [32]. Subcutaneous gentamicin injection is a welltolerated and is an effectively agent for treating cutaneous infections in adult patients [33]. Gentamicin is an effective antibiotic for empirical treatment of women with community-onset complicated and acute pyelonephritis [34].…”

Section: Treatment Of Bacterial Infections With Gentamicinmentioning

confidence: 99%

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Clinical Pharmacology of Gentamicin

Maria Pacifici

2023

JCRCT

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Gentamicin is an important agent for the treatment of many serious gram-negative bacillary infections. Gentamicin is the aminoglycoside of first-choice because the reliable activity against all but the most resistant gram-negative aerobes. Gentamicin preparations are available for parenteral, ophthalmic, and topical administration. The recommended intramuscular or intravenous dose of gentamicin sulphate for treatment of gram-negative organisms in adults with normal renal function is 5 to 7 mg/kg daily. For patients with renal dysfunction the interval between may be extended. The efficacy and safety of gentamicin have been reported but gentamicin may induce nephrotoxicity and/or ototoxicity in some patients. Gentamicin penetrates in significant amounts into bone, skeletal muscle, wound tissue, ischemic foot ulcers, and in subcutaneous tissue. The pharmacokinetics of gentamicin have been studied in febrile neutropenic adult patients and in healthy adult subjects and gentamicin elimination half-life is about 3 hours. The pharmacokinetics of gentamicin have been investigated in tetraplegic and in paraplegic adult patients and in healthy adult subjects and the elimination half-life of gentamicin is about 2 hours. The prophylaxis, treatment, and trials with gentamicin have been extensively reported. Gentamicin penetrates into the cerebrospinal fluid in significant amounts and treats bacterial meningitis in infants. Gentamicin is poorly transferred across the human placenta and poorly migrates into the breast-milk. The aim of this study is to review gentamicin efficacy and safety, toxicity, diffusion into body-tissues, pharmacokinetics, prophylaxis, treatment, trials, penetration into the cerebrospinal fluid, treatment of bacterial meningitis, transfer across the human placenta, and migration into the breast-milk.

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Section: Discussionmentioning

confidence: 99%

Section: Treatment Of Bacterial Infections With Gentamicinmentioning

confidence: 99%

Clinical Pharmacology of Gentamicin

Maria Pacifici

2023

JCRCT

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Çocuklarda Periton Dializi Uygulaması ve Komplikasyonları

Yıldız

Karaaslan

2019

Online Türk Sağlık Bilimleri Dergisi

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Günümüzde Böbrek yetmezliği tedavisindeki periton diyalizi kullanımı çocuklarda artmaktadır. Ancak periton diyaliz uygulaması yüksek komplikasyon oranları ile seyretmektedir. En sık peritonit, kateter tıkanması ve kateter migrasyonu nedeni ile kateter revizyonu gerekmektedir. Bu derlemenin amacı, komplikasyon oranlarını azaltmak için peritoneal kateter yerleştirme prosedürünün ipuçlarını ve uygun kateter tiplerini tanımlamaktır.

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Peritoneal Dialysis in Children

Bakal

Saraç

Tartar

et al. 2022

Nigerian Journal of Clinical Practice

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Background: Peritoneal dialysis (PD) is frequently used in pediatric patients with renal failure. Aim: In the present study, we evaluated the indications and complications of PD and patients' outcomes in pediatric patients. Patients and Methods: Medical records of patients who underwent PD between 2012 and 2019 were analyzed retrospectively. The patients were divided into two groups as acute PD (APD) (Group 1) and chronic PD (CPD) (Group 2). If the patient was diagnosed with acute kidney injury (AKI), an APD catheter was inserted, while a CPD catheter was inserted for patients with stage 5 chronic renal failure or those in which AKI persisted for more than 6 weeks. Results: Group 1 and Group 2 consisted of 62 and 64 patients, respectively. The most common indications for PD were AKI (64.5%) in Group 1, and obstructive uropathy and reflux nephropathy (45.3%) in Group 2. The overall complication rate was 30%. These were leakage at the catheter insertion site (11.2%), catheter occlusion (4.8%), and peritonitis (4.8%) in Group 1; and peritonitis (14.1%), catheter occlusion (6.2%), and inguinal hernia (4.6%) in Group 2. The mortality rate was 72.5% and 23.4% in Group 1 and Group 2, respectively. The most common causes of mortality were multisystem organ failure (40%) and sepsis (33.5%) in both groups. A total of 83 patients (32 in Group 1 and 51 in Group 2) had omentectomy. Catheter revision and/or removal were performed in 11.9% of all patients. Omentectomy had no effect on the prevention of catheter occlusion (p > 0.05). Conclusion: The mortality rate is lower in CPD patients than in APD patients. Although PD in pediatric patients is associated with potential complications, its actual rate is relatively low. The primary catheter dysfunction rate is low, and omentectomy has no significant effect on preventing catheter occlusion.

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Subcutaneous gentamicin injection around the cuff in treatment of resistant exit site infection in peritoneal dialysis patients: a pilot study

Cited by 3 publications

References 22 publications

Clinical Pharmacology of Gentamicin

Clinical Pharmacology of Gentamicin

Çocuklarda Periton Dializi Uygulaması ve Komplikasyonları

Peritoneal Dialysis in Children

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