Subcutaneous furosemide as palliative treatment in patients with advanced and terminal-phase heart failure

Efficacy and Safety of Subcutaneous Infusion of Non-formulated Furosemide in Patients with Worsening Heart Failure: a Real-World Study

“…One of these strategies is the outpatient diuretic treatment with SCF. For instance, prior authors have reported promising evidence of benefit in terms of symptoms improvement and weight loss with this diuretic strategy in small observational studies, mainly focused on palliative care [3,4,10,11]. Additionally, one small mechanistic randomized study reported complete bioavailability and equivalent diuresis and natriuresis with SCF compared with similar doses of conventional IV furosemide [12].…”

From Oral to Subcutaneous Furosemide: The Road to Novel Opportunities to Manage Congestion

“…25 Over the ensuing decade, multiple retrospective cohort studies assessed the diuretic efficacy of furosemide administered SC in patients with HF. [26][27][28][29][30][31] The target populations were primarily those with end-stage disease to maximize time spent at home and to prevent "revolving door"-style prolonged hospital admissions. For instance, Zacharias et al evaluated the impact of continuous SC furosemide infusion in 32 patients with end-stage HF (43 total episodes of severe congestion) on improving volume status, weight loss, and preventing hospitalizations.…”

“…Over the ensuing decade, multiple retrospective cohort studies assessed the diuretic efficacy of furosemide administered SC in patients with HF. 26 , 27 , 28 , 29 , 30 , 31 The target populations were primarily those with end-stage disease to maximize time spent at home and to prevent “revolving door”–style prolonged hospital admissions. For instance, Zacharias et al.…”