Subcutaneous fat necrosis of the newborn – An atypical case with typical complications

Lorenzo, Cristina Vidal; Romana, Andreia; Matias, Joana; Calhau, Paulo

doi:10.1002/ccr3.3945

Cited by 2 publications

(4 citation statements)

References 12 publications

(40 reference statements)

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“…In both of our patients with nephrocalcinosis, calcium did not normalize until after 2 years of age, suggesting that persistence of hypercalcemia may be an important risk factor for this complication. Long‐term hypercalcemia has been reported in the literature as a complication of SCFN 2,18 . Reassuringly, in both patients, nephrocalcinosis resolved upon serial imaging, in keeping with previous reports.…”

Section: Discussionsupporting

confidence: 88%

“…Long-term hypercalcemia has been reported in the literature as a complication of SCFN. 2,18 Reassuringly, in both patients, nephrocalcinosis resolved upon serial imaging, in keeping with previous reports. Chrysaidou et al reviewed 30 reported cases of SCFN complicated by nephrocalcinosis and nephrolithiasis.…”

Section: T a B L E 1 Demographics And Characteristicssupporting

confidence: 88%

“…Measuring total calcium alone would have missed 86% of cases of hypercalcemia in our study population. Several published reports describing hypercalcemia in SCFN used total calcium alone, which may explain our higher rate of hypercalcemia in our population 3,8,10,14,15,16,18 …”

Section: Discussionmentioning

confidence: 91%

“…Several published reports describing hypercalcemia in SCFN used total calcium alone, which may explain our higher rate of hypercalcemia in our population. 3,8,10,14,15,16,18 Complications of hypercalcemia occurred in 20% (n = 6) of the 29 patients with hypercalcemia. Complications were defined as clinical symptoms of hypercalcemia (fussiness, poor feeding, irritability)…”

Section: T a B L E 1 Demographics And Characteristicsmentioning

confidence: 99%

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Subcutaneous fat necrosis of the newborn: A retrospective study of 32 infants and care algorithm

Siegel

Alonso

Tuazon

et al. 2022

Pediatric Dermatology

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Objective: To describe the clinical and laboratory outcomes of infants with subcutaneous fat necrosis of the newborn (SCFN) and propose a care algorithm. Methods: This single-center, retrospective study of infants diagnosed with SCFN at Ann & Robert H. Lurie Children's Hospital of Chicago from 2009 to 2019.Results: Of 32 infants who met inclusion criteria, most were born full-term (84%), born via cesarean section (58%), had normal weight for gestational age (69%), and experienced delivery complications (53%). Twenty-nine infants (91%) had calcium drawn, and all had hypercalcemia. Three infants developed clinical symptoms of hypercalcemia, two required hospital admission, two developed nephrocalcinosis, and one developed acute kidney injury. The majority of infants (62%) had a peak ionized calcium between 1.5 and 1.6 mmol/L. No infants with peak ionized calcium less than 1.5 mmol/L developed complications of hypercalcemia. Most patients were diagnosed with hypercalcemia (86%) and demonstrated peak ionized calcium levels (59%) within the first 28 days of life. No patients developed hypercalcemia after 3 months of age. Conclusion:Hypercalcemia occurred in 100% of infants who had laboratory monitoring. We recommend obtaining an initial ionized calcium level when SCFN is suspected, and monitoring for the first 3 months of life if hypercalcemia has not been detected. In patients with asymptomatic hypercalcemia less than 1.5 mmol/L, there appears to be low likelihood of related complications. For symptomatic, markedly elevated (>1.6 mmol/L), or persistently elevated levels (>6 months) we suggest coordinated care with endocrinology or nephrology, consider hospitalization, and urinary system ultrasound.

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Section: Discussionsupporting

confidence: 88%

Section: T a B L E 1 Demographics And Characteristicssupporting

confidence: 88%

Section: Discussionmentioning

confidence: 91%

Section: T a B L E 1 Demographics And Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Subcutaneous fat necrosis of the newborn: A retrospective study of 32 infants and care algorithm

Siegel

Alonso

Tuazon

et al. 2022

Pediatric Dermatology

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A Hypercalcemic Crisis Complicating Subcutaneous Fat Necrosis of the Newborn: A Case Report and Literature Review

Marhoon,

Ali,

Elshabrawy

2024

Cureus

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Subcutaneous fat necrosis of the newborn (SFNN) is a rare panniculitis that is characterized by the presence of skin nodules. Although SFNN is a self-limited benign disease, effective follow-up is highly recommended to detect hypercalcemia and other complications early on. A male newborn was admitted twice to the neonatal intensive care unit (NICU). The first NICU admission was for hypoglycemia, and the second was due to late-onset sepsis, in which reddish nodules were detected on the back, flanks, shoulders, and posterior aspects of the legs. At 44 days old, the infant was referred to the emergency department due to a hypercalcemic crisis. Screening for other SFNN complications revealed eosinophilia, hypoglycemia, and nephrocalcinosis. The hospitalization was further complicated by a rare occurrence of deep venous thrombosis. The calcium level was followed up to ensure the patient’s recovery. This case highlights the complications that might follow SFNN and emphasizes the importance of its surveillance.

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Subcutaneous fat necrosis of the newborn – An atypical case with typical complications

Cited by 2 publications

References 12 publications

Subcutaneous fat necrosis of the newborn: A retrospective study of 32 infants and care algorithm

Subcutaneous fat necrosis of the newborn: A retrospective study of 32 infants and care algorithm

A Hypercalcemic Crisis Complicating Subcutaneous Fat Necrosis of the Newborn: A Case Report and Literature Review

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