Subcutaneous Fat Necrosis of the Newborn and Idiopathic Hypercalcemia

Thomsen, Robert J.

doi:10.1001/archderm.1980.01640340065018

Cited by 55 publications

(9 citation statements)

References 12 publications

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“…SCFN is a harmless, self limiting condition, but appreciable morbidity and mortality can result from the associated hypercalcaemia, the pathogenesis of which is not known. [3][4][5][6][7][8] Potential causes include increased prostaglandin activity leading to osteoclast activation, calcium release from necrotic fat cells, and increased production of 1,25-dihydroxyvitamin D by macrophages, leading to increased bone turnover. [11][12][13] The incidence of hypercalcaemia as a complication is uncertain.…”

Section: Discussionmentioning

confidence: 99%

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Subcutaneous fat necrosis of the newborn: hypercalcaemia with hepatic and atrial myocardial calcification

Dudink

2003

Archives of Disease in Childhood - Fetal and Neonatal Edition

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Subcutaneous fat necrosis of the newborn (SCFN) is a very rare disorder, which can be complicated by hypercalcaemia and thrombocytopenia. The case is presented of an infant with SCFN and symptomatic hypercalcaemia, who developed calcifications in the liver, the inferior vena cava, and the atrial septum of the heart. The hypercalcaemia was treated with hyperhydration, frusemide, glucocorticoids, and a diet low in calcium and vitamin D. Clinical features, diagnosis, complications, and treatment of this rare condition are discussed.

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Section: Discussionmentioning

confidence: 99%

“…1 2 Hypercalcaemia is a complication of SCFN, which can be life threatening if not treated adequately. [3][4][5][6][7][8] …”

mentioning

confidence: 99%

Subcutaneous fat necrosis of the newborn: hypercalcaemia with hepatic and atrial myocardial calcification

Dudink

2003

Archives of Disease in Childhood - Fetal and Neonatal Edition

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Section: Background/introductionmentioning

confidence: 99%

“…Subcutaneous fat necrosis of the newborn (SFNN) is a recognized but uncommon disorder primarily affecting full‐term and post‐term infants, usually within the first few weeks of life . The disorder is characterized by firm, red or purple subcutaneous nodules and plaques on the trunk, buttocks, cheeks, and extremities and is associated with perinatal stress . Although the pathogenesis of the disorder is currently unknown, precipitating factors may include asphyxia, hypothermia/cold exposure, meconium aspiration, hypoxemia, obstetric trauma, and maternal conditions such as preeclampsia and diabetes .…”

Section: Background/introductionmentioning

confidence: 99%

Subcutaneous fat necrosis of the newborn and associated hypercalcemia: A systematic review of the literature

Stefanko

Drolet

2018

Pediatric Dermatology

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Subcutaneous fat necrosis of the newborn is an uncommon disorder, and although usually benign, associated hypercalcemia can lead to complications such as failure to thrive and renal failure. Many sources suggest screening for hypercalcemia for 6 months following resolution of skin lesions, but little data are available to support this recommendation. This study examines existing published literature to better guide practitioners regarding screening evaluations of asymptomatic patients with subcutaneous fat necrosis. A systematic review of the literature was conducted using a PubMed English literature search. Data from case reports and case series were collected regarding the presence of hypercalcemia and associated complications, birth history, and age of onset/resolution of skin lesions and laboratory abnormalities. Approximately half (51%) of infants reported had hypercalcemia. Most (77%) developed detectable hypercalcemia within 30 days of skin lesion onset, and 95% developed detectable hypercalcemia within 60 days of skin lesion onset. Hypercalcemia was detected in only 4% of patients > 70 days following onset of skin lesions. Seventy-six percent had resolution of hypercalcemia within 4 weeks of detection. Hypercalcemia was more prevalent in full-term vs pre-term infants (P-value = 0.054), and higher birthweight was significantly associated with an increased risk of developing hypercalcemia (P-value = 0.022). Although gestational age trended toward significance, the only statistically significant clinical feature predicting the development of hypercalcemia was higher birthweight. Current recommendations for laboratory monitoring are not evidence-based, and this study provides interim data to guide practitioners until prospective, randomized controlled trials are conducted.

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“…Thomsen [7] reviewed 15 cases of SCFN associated with idiopathic hypercalcemia or subcutaneous calcifica tions. Hypercalcemia has been correlated with granuloma formation in SCFN of the newborn.…”

Section: Discussionmentioning

confidence: 99%

Subcutaneous Fat Necrosis with Thrombocytopenia in a Newborn Infant

et al. 1990

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A case of subcutaneous fat necrosis (SCFN) in a newborn who had suffered from asphyxia secondary to meconium aspiration is described. During the third week of life, bluish-red subcutaneous nodules were noticed. A biopsy of the lesions showed subcutaneous necrosis with fat cells containing needle-like crystals with reactive inflammatory infiltrates. Peripheral transient thrombocytopenia was observed prior to the appearance of subcutaneous fat necrosis. The good prognosis is stressed.

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Subcutaneous Fat Necrosis of the Newborn and Idiopathic Hypercalcemia

Cited by 55 publications

References 12 publications

Subcutaneous fat necrosis of the newborn: hypercalcaemia with hepatic and atrial myocardial calcification

Subcutaneous fat necrosis of the newborn: hypercalcaemia with hepatic and atrial myocardial calcification

Subcutaneous fat necrosis of the newborn and associated hypercalcemia: A systematic review of the literature

Subcutaneous Fat Necrosis with Thrombocytopenia in a Newborn Infant

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