In this report, we present a case of influenza B-associated spontaneous pneumomediastinum (SPM) and subcutaneous emphysema (SE) in a young male patient. Although there are several causes responsible for this condition, it is considered extremely rare to occur spontaneously with no prior trauma or predisposing factors, especially in older age groups.Rare cases of SPM and SE, as described in several case reports worldwide, have been reported to have a benign course for the most part. Nevertheless, implementing unified management guidelines with clear protocols is highly recommended to prevent the potential unfavorable complications associated with these conditions.