Subcutaneous Administration of Sodium Alginate Oligosaccharides Prevents Salt-Induced Hypertension in Dahl Salt-Sensitive Rats

Moriya, Chikako; Shida, Yui; Yamane, Yuki; Miyamoto, Yuki; Kimura, Midori; Huse, Naomi; Ebisawa, Kaori; Kameda, Yuki; Nishi, Ayaka; Du, Dongping; Yoshinaga, Mariko; Murota, Itsuki; Sato, Nobuyuki; Uehara, Yoshio

doi:10.3109/10641963.2013.776568

Cited by 37 publications

(35 citation statements)

References 11 publications

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“…In addition, it is also documented to attenuate hypertension, associated kidney damage. 10 Therefore, we hypothesize that administration of LvSA may preserve renal function, prevent histological alterations in LA-induced nephrotoxicity with mild chelation and by suppressing oxidative stress. Additionally, LvSA will be evaluated with suitable biochemical and histopathological parameters for its possible Reno protective effect.…”

Section: Introductionmentioning

confidence: 99%

Nephroprotective Effect of Low Viscosity Sodium Alginate on Lead Acetate-Induced Nephrotoxicity in Rats

Kaur¹,

Sharma²

2017

IJPER

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Objective: Renal failure in majority of population is considered to be idiopathic. Heavy metals like lead in drinking water are usually the hidden cause of these renal consequences. Thus, this study has been designed to investigate the effect of low viscosity sodium alginate (LvSA) in Lead-induced nephrotoxicity. Methods: Lead (0.2% lead acetate in drinking water for 5 weeks) was administered in rats to produce nephrotoxicity assessed in terms of histopathological changes, increase in serum creatinine, blood urea nitrogen, urinary N-acetyl-β D glucosaminidase (NAG), proteinuria, Thiobarbituric acid reactive substances (TBARS) and decrease in reduced glutathione level. Results : Lead acetate (LA) intoxication shown elevations in serum creatinine, Proteinuria, glomerular filtration rate (GFR), blood urea nitrogen (BUN), Thiobarbituric acid reactive substances (TBARS), altered urinary N-acetyl-β D glucosaminidase (NAG), kidney weight/ body weight ratio (KW/BW %), and creatinine clearance that indicate renal damage. Treatment with Low viscosity sodium alginate (LvSA) show significant decrease in serum creatinine, BUN, urinary NAG, protein in urine, KW/BW %, TBARS level and increase in GSH, creatinine clearance and GFR. Conclusion: Thus, on the basis of results it may be concluded that LvSA significantly attenuated Lead-induced nephrotoxicity.

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Section: Introductionmentioning

confidence: 99%

Nephroprotective Effect of Low Viscosity Sodium Alginate on Lead Acetate-Induced Nephrotoxicity in Rats

Kaur¹,

Sharma²

2017

IJPER

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“…Mechanisms involved in antihypertensive effects of AOS were investigated by Moriya et al. (). Subcutaneous administration of AOS (60 mg/day) for 14 days in Dahl S rat fed a high‐salt diet (4% NaCl) almost completely abolished salt‐induced hypertension.…”

Section: Health Beneficial Effects and Potential Aos Applicationsmentioning

confidence: 99%

Alginate Oligosaccharides: Production, Biological Activities, and Potential Applications

Liu

Yang

et al. 2019

Comp Rev Food Sci Food Safe

207

121

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Alginate, a group of polyuronic saccharides, has been widely used in both pharmaceutical and food industries due to its unique physicochemical properties as well as beneficial health effects. However, the potential applications of alginate are restricted because of its low water solubility and high solution viscosity when significant concentrations are needed, particularly in food products. Alginate oligosaccharides (AOS), oligomers containing 2 to 25 monomers, can be obtained via hydrolysis of glycosidic bonds, organic synthesis, or through biosynthesis. Generally, AOS have shorter chain lengths and thus improved water solubility when compared with higher molecular weight alginates of the same monomers. These oligosaccharides have attracted interest from both basic and applied researchers. AOS have unique bioactivity and can impart health benefits. They have shown immunomodulatory, antimicrobial, antioxidant, prebiotic, antihypertensive, antidiabetic, antitumor, anticoagulant, and other activities. As examples, they have been utilized as prebiotics, feed supplements for aquaculture, poultry, and swine, elicitors for plants and microorganisms, cryoprotectors for frozen foods, and postharvest treatments. This review comprehensively covers methods for AOS production from alginate, such as physical/chemical methods, enzymatic methods, fermentation, organic synthesis, and biosynthesis. Moreover, current progress in structural characterization, potential health benefits, and AOS metabolism after ingestion are summarized in this review. This review will discuss methods for producing and modified AOS with desirable structures that are suited for novel applications.

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“…It currently is being evaluated as a treatment for chronic respiratory diseases such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) [48]. Furthermore, Guo et al (2016) found that AOS decreased the expression of Caspase-12, C/EBP homologous protein (CHOP) and Bax while upregulating the expression of anti-apoptotic protein Bcl-2, which are markers for endoplasmic reticulum-mediated apoptosis [51]. Taken together, these results demonstrated that AOS is a promising compound that prevents acute DOX cardiotoxicity via inhibition of oxidative stress and endoplasmic reticulum-mediated apoptosis [51].…”

Section: Pharmaceutical and Biomedical Applicationsmentioning

confidence: 99%

“…Furthermore, Guo et al (2016) found that AOS decreased the expression of Caspase-12, C/EBP homologous protein (CHOP) and Bax while upregulating the expression of anti-apoptotic protein Bcl-2, which are markers for endoplasmic reticulum-mediated apoptosis [51]. Taken together, these results demonstrated that AOS is a promising compound that prevents acute DOX cardiotoxicity via inhibition of oxidative stress and endoplasmic reticulum-mediated apoptosis [51]. Therefore, with the unique properties of AOS and their derivatives, they might be beneficial biomedicine in many diseases.…”

Section: Pharmaceutical and Biomedical Applicationsmentioning

confidence: 99%

Marine Alginate Oligosaccharides – A Promising Biomaterial: Current Use and Future Perspectives in Food Industry and Pharmaceutical Applications

Cuong¹,

Nguyen²,

Kim

2018

JST

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Abstract. Alginate oligosaccharides (AOS) have been known as a natural material with a wide variety of biological activities, and used for a long time. The evidence of using AOS to confer health benefits have been documented. The isolation and characterization of the properties, biological activity as well as the applications of AOS in various fields have been studied recently. In present work, we provide the recent research of AOS, particularly focusing on the applications in food and medicinal industry. This review also describes some experimental models, application and discuss the functional and biological mechanisms of AOS. In conclusion, AOS promotes beneficial effects on the immuno-metabolic response to various infectious diseases as well as it is promising as a biomaterial for functional foods and medicinal drugs development.

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Subcutaneous Administration of Sodium Alginate Oligosaccharides Prevents Salt-Induced Hypertension in Dahl Salt-Sensitive Rats

Abstract: Our results suggest that sodium alginate oligosaccharides attenuate salt-induced hypertension in Dahl S rats not through reducing salt absorption, but probably through a direct action on vascular vessels.

Cited by 37 publications

References 11 publications

Nephroprotective Effect of Low Viscosity Sodium Alginate on Lead Acetate-Induced Nephrotoxicity in Rats

Nephroprotective Effect of Low Viscosity Sodium Alginate on Lead Acetate-Induced Nephrotoxicity in Rats

Alginate Oligosaccharides: Production, Biological Activities, and Potential Applications

Marine Alginate Oligosaccharides – A Promising Biomaterial: Current Use and Future Perspectives in Food Industry and Pharmaceutical Applications

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