Subcortical Vascular versus Amnestic Mild Cognitive Impairment: Comparison of Cerebral Glucose Metabolism

Seo, Sang Won; Cho, Sang Soo; Park, Aram; Chin, Juhee; Na, Duk L.

doi:10.1111/j.1552-6569.2008.00292.x

Cited by 91 publications

(67 citation statements)

References 28 publications

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“…One previous SPECT study found that patients with aMCI showed hypometabolism in the frontal and subcortical areas and their abnormal social behaviors may be attributed to the impaired frontalsubcortical circuits [31]. Furthermore, [32] these studies also found that frontal cortical In our study, the loss of gray matter volume and reduction of ALFF were observed in the superior temporal gyrus and insula, which is consistent with the Xenon-enhanced computed tomography PET study [33]. A previous PET study also suggested that loss of metabolism also occurs at these two regions in the prodromal stage of AD [34].…”

Section: Discussionsupporting

confidence: 80%

Early morphological brain abnormalities in patients with amnestic mild cognitive impairment

Yin¹,

Jia

et al. 2014

Translational Neuroscience

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Patients with amnestic mild cognitive impairment (aMCI) are at an increased risk of further deterioration and eventually developing Alzheimer's disease (AD). Therefore, the identification of specific markers for this disease such as radiological markers is of great diagnostic and clinical significance. Our previous work has shown that magnetic resonance imaging (MRI) is a powerful tool to identify unique imaging features in patients with aMCI. Herein, we calculated the gray matter volume by structural magnetic resonance imaging (sMRI), and spontaneous low frequency fluctuations (LFF) using resting-state functional MRI (rs-fMRI) in 11 patients with aMCI and 22 normal control patients. Compared with the control group, patients with aMCI showed significant reduction of gray matter volume in the inferior frontal gyrus, inferior parietal lobule, anterior cingulated cortex, and insula and superior temporal gyrus. Patients with aMCI also showed significantly lower amplitudes of low-frequency fluctuations (ALFF) in the posterior cingulate cortex, precuneus, temporal gyrus and inferior parietal lobule when compared with the control group. However, in several other brain regions including the occipital lobe and cerebellum, the ALFF in patients with aMCI was significantly increased. The variation in ALFF between the two groups remained significant after adjustment for structural differences. Our results obtained in this pilot study are consistent with our previous finding and collectively show that patients with aMCI have abnormal MRI imaging findings. The pathological basis of these imaging features in patients with aMCI needs to be further explored.

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Section: Discussionsupporting

confidence: 80%

Early morphological brain abnormalities in patients with amnestic mild cognitive impairment

Yin¹,

Jia

et al. 2014

Translational Neuroscience

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“…Patients with SVaD met the diagnostic criteria for vascular dementia as determined by the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition), and also fulfilled the imaging criteria for SVaD proposed by Erkinjuntti et al (Erkinjuntti et al, 2000). Patients with aMCI and svMCI met Petersen's criteria for MCI with modifications (Seo et al, 2009). All svMCI and SVaD patients had severe white matter hyperintensities (WMH) on their MRI scans, which was defined as a cap or band (periventricular WMH) ≥10mm and deep WM lesions (deep WMH) ≥25mm, as modified from the Fazekas ischemia criteria (Fazekas et al, 1993).…”

Section: Participantsmentioning

confidence: 99%

MRI-visible perivascular space location is associated with Alzheimer's disease independently of amyloid burden

Banerjee

Kim

Fox

et al. 2017

Brain

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192

216

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MRI-visible perivascular spaces are a neuroimaging marker of cerebral small vessel disease.Their location may relate to the type of underlying small vessel pathology: those in the white matter centrum semi-ovale have been associated with cerebral amyloid angiopathy, whilst those in the basal ganglia have been associated with deep perforating artery arteriolosclerosis.Since cerebral amyloid angiopathy is an almost invariable pathological finding in Alzheimer's disease, we hypothesized that MRI-visible perivascular spaces in the centrum semi-ovale would be associated with a clinical diagnosis of Alzheimer's disease, whereas those in the basal ganglia would be associated with subcortical vascular cognitive impairment. We also hypothesised that MRI-visible perivascular spaces in the centrum semiovale would be associated with brain amyloid burden, as detected by amyloid-PET using subcortical vascular cognitive impairment n=116) with standardised MRI and PiB-PET imaging were included. MRI-visible perivascular spaces were rated using a validated 4-point visual rating scale, and then categorised by severity ("none/mild", "moderate" or "frequent/severe").

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“…Patients with amnestic mild cognitive impairment (aMCI, n 5 45) and those with subcortical vascular mild cognitive impairment (svMCI, n 5 67) met the Petersen criteria for mild cognitive impairment with modifications. 13 Patients with probable AD dementia (n 5 69) met criteria proposed by the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association. 14 Patients with SVaD (n 5 70) met the diagnostic criteria for vascular dementia as determined by the DSM-IV, and also met the imaging criteria for SVaD proposed by Erkinjuntti et al 15 Patients with svMCI and SVaD had severe WMH on fluid-attenuated inversion recovery (FLAIR) images, which was defined as periventricular WMH $10 mm and deep WMH $25 mm, as modified from the Fazekas ischemia criteria.…”

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confidence: 99%

Clinical effect of white matter network disruption related to amyloid and small vessel disease

Kim

Kwon

et al. 2015

Neurology

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Subcortical Vascular versus Amnestic Mild Cognitive Impairment: Comparison of Cerebral Glucose Metabolism

Abstract: Our study suggested that svMCI was distinct from aMCI in terms of neuropsychological and PET findings, which may explain their clinical manifestations.

Cited by 91 publications

References 28 publications

Early morphological brain abnormalities in patients with amnestic mild cognitive impairment

Early morphological brain abnormalities in patients with amnestic mild cognitive impairment

MRI-visible perivascular space location is associated with Alzheimer's disease independently of amyloid burden

Clinical effect of white matter network disruption related to amyloid and small vessel disease

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