Subcortical neuronal correlates of the component P300 in man

Kropotov, J.D.; Пономарев, В. А.

doi:10.1016/0167-8760(91)90207-e

Cited by 12 publications

(19 citation statements)

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“…Depth recordings have demonstrated P300-like activity in the ventral᎐ Ž . lateral Kropotov and Ponomatrev, 1991 and me-Ž dial geniculate thalamic nuclei Velasco et al, . 1989 .…”

Section: Discussionmentioning

confidence: 99%

“…Multiple brain structures generate P300-like potentials, including the hippocampus, parahippocampal gyrus, temporoparietal junction, thala-Ž mus and frontal cortex Knight et al, 1989;McCarthy et al, 1989;Smith et al, 1990;Kropotov . and Ponomatrev, 1991 .…”

Section: Discussionmentioning

confidence: 99%

“…Isreal et al, 1980; . Kramer et al, 1983;Trestman et al, 1996 . Much evidence implicates multiple generators of scalp-recorded P300 activity, with contributions from the hippocampus, parahippocampal gyrus, temporoparietal junction, thalamus and frontal Ž cortex Knight et al, 1989;McCarthy et al, 1989;Smith et al, 1990;Kropotov and Ponomatrev, . 1991 .…”

Section: Introductionmentioning

confidence: 99%

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Relationship between auditory P300 amplitude and age of onset of schizophrenia in older patients

Olichney

Iragui

Kutas

et al. 1998

Psychiatry Research

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Auditory P300 amplitude reductions are well-established in young adults with schizophrenia. Little is known, however, regarding the P300 in older schizophrenia patients, especially those with late onset. We studied 28 Ž . w Ž . middle-aged and elderly mean age s 62.7 years patients 14 with early onset schizophrenia EOS and 14 with late Ž .x Ž . onset schizophrenia LOS and 14 normal comparison NC participants using an auditory oddball paradigm. Event-related potentials were recorded from 15 scalp electrodes and six non-scalp sites. There were no significant differences between EOS and LOS groups in neuroleptic dosage, symptom severity, reaction times, target-detection accuracy, or N100 and N200 ERP measures. The EOS, but not the LOS, group had significantly smaller auditory oddball P300 amplitudes than the NC group. Twelve of the 14 LOS patients had P300 amplitudes in the normal Ž . range. Smaller P300 amplitudes were associated with earlier age of onset r s 0.48 , longer duration of illness Ž . Ž . r sy0.49 and more severe alogia r sy0.50 . We conclude that P300 abnormalities in schizophrenia may be a marker for a disease subtype with early onset and more severe information-processing deficits. ᮊ

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“…Depth recordings have demonstrated P300-like activity in the ventral᎐ Ž . lateral Kropotov and Ponomatrev, 1991 and me-Ž dial geniculate thalamic nuclei Velasco et al, . 1989 .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between auditory P300 amplitude and age of onset of schizophrenia in older patients

Olichney

Iragui

Kutas

et al. 1998

Psychiatry Research

View full text Add to dashboard Cite

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“…Intracranial recording studies of the electrical potential evoked by visual and/or auditory stimuli reported that the generators of the P300 wave are derived from the hippocampus and adjacent regions in the medial temporal lobe (McCarthy et al, 1989;Smith et al, 1990;Kropotov and Ponomarev, 1991;Paller et al, 1992). In addition, scalp topography of P300 potentials evoked by somatosensory stimuli is not significantly different from that evoked by auditory and visual stimuli (Snyder et al, 1980;McCarthy et al, 1989).…”

Section: Introductionmentioning

confidence: 97%

Magnetic fields in the human hippocampal area evoked by a somatosensory oddball task

et al. 2004

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We recorded neuromagnetic fields evoked by a somatosensory oddball task requiring subjects to discriminate target stimuli from nontarget stimuli, which are different in stimulation intensity, with a mental count of the target stimuli. A whole head type 80-channel magnetoencephalography (MEG) system with a 50-mm baseline gradiometer array was used. Targets and nontargets were somatosensory stimuli with an electrical current intensity of twice and three times the sensory threshold, respectively. The source current locations of the evoked magnetic fields in three dimensions and the equivalent current dipole (ECD) moments were calculated by using a single dipole model, assuming the brain as a sphere. In 28 of 63 recording sessions for 7 subjects, the loci of neuronal activities were observed in the left and/or right hippocampal areas. The latency of left hippocampal activity (293 +/- 49 ms) was significantly shorter than that of the right (333 +/- 45 ms) (P = 0.027, non-paired t-test). In view of previous studies that have shown the time window of sensory integration as approximately 200-300 ms, sensory information may be transferred to hippocampal areas following sensory integration.

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“…Although we are aware that there is accumulating evidence that the P3 represents the compound activity of multiple generators (e.g., Kropotov and Ponomarev 1991), in this experiment P3 topography could consistently (over conditions and over samplepoints) be modeled with a single ECD in the left posterior (occipital-temporal) hemisphere. Left-hemispheric lateralization of the P3 is to our knowledge not a wellknown phenomenon.…”

Section: Discussionmentioning

confidence: 89%

Topography and source analysis of brain activity associated with selective spatial attention and memory search

et al. 1993

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Sum~nary~ We investigated the topographical aspects of the ERP reflections of visual spatial attention and memory search. Spatial attention was found to enhance the amplitudes of the P1 and N1 deflections. The brain activity in the P1-N1 latency range could be modeled with a single moving equivalent dipole, or alternatively with two stationary dipoles in a spatio-temporal dipole model. The dipoles were located in mesial and lateral posterior brain regions. Similar dipole solutions were obtained for ERPs to attended and unattended stimuli. Increasing the memory search requirements of the task resulted in an increase of late negativity, which was topographically distinguishable from the P3 component.

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Subcortical neuronal correlates of the component P300 in man

Cited by 12 publications

References 0 publications

Relationship between auditory P300 amplitude and age of onset of schizophrenia in older patients

Relationship between auditory P300 amplitude and age of onset of schizophrenia in older patients

Magnetic fields in the human hippocampal area evoked by a somatosensory oddball task

Topography and source analysis of brain activity associated with selective spatial attention and memory search

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