Subcortical ischemic vascular disease and cognition: A systematic review

Alves, Gilberto Sousa; Alves, Carlos Eduardo de Oliveira; Lanna, Maria Elisa de Oliveira; Moreira, Denise Madeira; Engelhardt, Eliasz; Laks, Jérson

doi:10.1590/s1980-57642009dn20200002

Cited by 11 publications

(5 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Currently, it is accepted that executive dysfunction is associated with the prefrontal-striatal pathway impairment. [ 13 ] The prefrontal-striatal pathway impairment may cause damage to the top-down control in the prefrontal lobe, resulting in executive dysfunction syndrome [ 16 ] which is characterized by abnormalities in the executive control, working memory, and dominant response inhibition as well as psychomotor retardation. Some studies propose that WML mainly affect the structure and function of prefrontal-striatal pathway [ 17 ] and disrupt the signal transduction between neurons and between prefrontal cortex and subcortical center, finally leading to the executive dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Correlation between prefrontal-striatal pathway impairment and cognitive impairment in patients with leukoaraiosis

Wang¹,

Yuan

Guo³

et al. 2017

Medicine

View full text Add to dashboard Cite

Our study aimed to investigate the changes of white matter microstructure of cortico-subcortical pathways using diffusion tensor imaging (DTI), and to explore the relationship between abnormal parameters of DTI and cognitive function underlying in patients with leukoaraiosis (LA).A total of 42 patients with LA and 42 age- and sex-matched healthy controls were recruited from Beijing Chaoyang Hospital, Capital Medical University between January 2012 and December 2012. All the subjects underwent scans of conventional magnetic resonance imaging and DTI, and a comprehensive neuropsychological battery was utilized. The regions of interest (ROIs) were located at the white matter of centrum semiovale, anterior and posterior periventricular white matter, basal ganglia, corpus callosum. The averaged values of mean diffusivity (MD) and fractional anisotropy (FA) were quantified both within white matter lesions (WMLs) and normal appearing white matter (NAWM). A linear regression analysis was performed to assess the association between diffusion parameters and decline in cognitive domains.Patients with LA were associated with comprehensive cognitive function deficits. We found that significantly decreased FA and increased MD in WMLs at the 5 ROIs than that of NAWM and controls (P < .05). The values of FA in NAWM were significantly lower and MD in NAWM were significantly higher at centrum semiovale and posterior periventricular white matter than that of controls (P < .05). The values of FA in WMLs at anterior periventricular white matter were positively related to the performances of cognition in patients with LA (P < .05). The values of FA in NAWM located at anterior periventricular white matter were positively related to the score of Digit-symbol test (r = 0.446, P = .002). The values of FA in NAWM located at anterior periventricular white matter correlated inversely with the Z scores of executive function (r = −0.418, P = .03).In our study, patients with LA exhibited significant cognitive impairment especially in the domains of executive function. The technique of DTI revealed that the reduced FA and increased MD at the corresponding regions of cortico-subcortical pathways in patients with LA. DTI may be of great help for an early pathology of white matter microstructure underlying in patients with LA.

show abstract

Section: Discussionmentioning

confidence: 99%

Correlation between prefrontal-striatal pathway impairment and cognitive impairment in patients with leukoaraiosis

Wang¹,

Yuan

Guo³

et al. 2017

Medicine

View full text Add to dashboard Cite

show abstract

“…In support of this finding, researchers have proven over the years that patients with a history of stroke with large infarcts involving the cerebral cortex or the anterior and posterior arteries in the left hemisphere of the brain experience significant cognitive impairment in their memory functions, attention, orientation and language abilities (28). Researchers also believe that stroke can cause cognitive impairment, especially in areas of executive functioning, attention, memory and recall by the lesions it creates in the white matter (29). Researchers have also found that learning ability and verbal recall can be weakened even in patients with a mild stroke (30).…”

Section: Discussionmentioning

confidence: 95%

Cognitive Impairment and Its Associated Factors in Patients Undergoing Hemodialysis: A Cross Sectional Study

Saberi

Monfared

Sobhani

et al. 2017

Caspian.J.Neurol.Sci

View full text Add to dashboard Cite

Background: Hemodialysis is a treatment for end-stage renal disease (ESRD) that is an underlying factor of cognitive impairment in patients.Objectives: This study was conducted to evaluate the prevalence of cognitive impairment and its associated factors in patients undergoing hemodialysis using Montreal Cognitive Assessment (MoCA). Materials and Methods:This cross-sectional study was carried out in 2016 in the dialysis unit of an academic hospital in the north of Iran. A total of two hundreds and twenty-four patients with chronic renal failure and ESRD presenting to for hemodialysis were included. All the patients were evaluated by the MoCA and the cut-off point was set at ≤25 for confirming cognitive impairment. The data obtained were analyzed in SPSS-18 using the Chi-square test, Mann-Whitney's U-test, Fisher's exact test, the independent t-test and the binomial logistic regression.Results: From the total of 224 patients examined, 93 (41.52%) had developed cognitive impairment. The variables of age, stroke, education and diabetes were entered into the logistic regression model to analyze the associated risk factors, but only age and a history of stroke showed a significant relationship with this impairment; that is, the possibility of cognitive impairment increases with increasing age and a history of stroke can increase its risk six-fold. Conclusion:Cognitive impairment was a relatively frequent complication of hemodialysis in this study which was performed in the north of Iran. Aging and a history of stroke are risk factors of cognitive impairment in patients with chronic kidney failure undergoing hemodialysis treatment.

show abstract

“…As a hallmark of SIVCI, 40 higher WMH is signi cantly correlated with poorer postural stability. 5,41 Hippocampal, WMH, and ICV were calculated and obtained from previous analysis.…”

Section: Structural Mri Analysismentioning

confidence: 99%

Functional Neural Networks of Physical Reserve Moderate the Association between White Matter Hyperintensity and Postural Balance in Older Adults with Subcortical Ischemic Vascular Cognitive Impairment

Hsu,

Holtzer,

Tam

et al. 2024

Preprint

View full text Add to dashboard Cite

White matter hyperintensities (WMH) are markers of subcortical ischemic vascular cognitive impairment (SIVCI) associated with impaired postural balance. Physical reserve (PR) is a recently established construct that reflects one’s capacity to maintain physical function despite brain pathology. This cross-sectional study aims to map functional networks associated with PR, and examining the relationship between PR, WMH, and postural balance. PR was defined in 22 community-dwelling older adults with SIVCI. Functional networks of PR were computed using general linear model. Subsequent analyses examined whether PR and relevant networks moderated the relationship between WMH and postural balance under two conditions – eyes open while standing on foam (EOF) or on floor (EONF). We found that PR and the relevant networks - frontoparietal network (FPN) and default mode network (DMN) - significantly moderated the association between WMH and postural balance. For individuals with high PR, postural balance remained stable regardless of the extent of WMH load; whereas for those with low PR, postural balance worsened as WMH load increased. These results suggest the attenuated effects of WMH on postural stability due to PR may be underpinned by functional neural network reorganization in the FPN and DMN as a part of compensatory processes.

show abstract

Subcortical ischemic vascular disease and cognition: A systematic review

Cited by 11 publications

References 61 publications

Correlation between prefrontal-striatal pathway impairment and cognitive impairment in patients with leukoaraiosis

Correlation between prefrontal-striatal pathway impairment and cognitive impairment in patients with leukoaraiosis

Cognitive Impairment and Its Associated Factors in Patients Undergoing Hemodialysis: A Cross Sectional Study

Functional Neural Networks of Physical Reserve Moderate the Association between White Matter Hyperintensity and Postural Balance in Older Adults with Subcortical Ischemic Vascular Cognitive Impairment

Contact Info

Product

Resources

About