Subcortical imaging-derived phenotypes are associated with the risk of Parkinson’s disease: A Mendelian Randomization Study
Zhichun Chen,
Jun Liu,
Yong You
Abstract:Background The abnormalities of subcortical structures, such as putamen and caudate, play a key role in the occurrence of Parkinson's disease (PD); however, whether and how imaging-derived phenotypes (IDPs) in subcortical structures are causally associated with the risk of PD remain poorly understood. Methods The causal associations between subcortical IDPs from UK biobank and risk of PD were evaluated with bidirectional two-sample Mendelian randomization (MR) studies. Results Totally five subcortical IDPs wer… Show more
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