Subcortical control of the default mode network: Role of the basal forebrain and implications for neuropsychiatric disorders

Aguilar, David D; McNally, James M.

doi:10.1016/j.brainresbull.2022.05.005

Cited by 13 publications

(9 citation statements)

References 137 publications

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“…Furthermore, AI stimulationinduced heterogenous deactivation and connectivity patterns along the AP axis of RSC, which were particularly apparent during the brief transition state, point to the existence of distinct functional modules within the rodent RSC. Deep-brain structures have been implicated in DMN function and regulation 51,52 (see Supplementary Information: Discussion #7 for a summary of recent findings). Given that these structures are reciprocally connected with the AI 53,54 , DMN-SN network dynamics in real-world situations are likely the product of deep-brain influences and the cortical interactions described here.…”

Section: Discussionmentioning

confidence: 99%

Optogenetic stimulation of anterior insular cortex neurons in male rats reveals causal mechanisms underlying suppression of the default mode network by the salience network

et al. 2023

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The salience network (SN) and default mode network (DMN) play a crucial role in cognitive function. The SN, anchored in the anterior insular cortex (AI), has been hypothesized to modulate DMN activity during stimulus-driven cognition. However, the causal neural mechanisms underlying changes in DMN activity and its functional connectivity with the SN are poorly understood. Here we combine feedforward optogenetic stimulation with fMRI and computational modeling to dissect the causal role of AI neurons in dynamic functional interactions between SN and DMN nodes in the male rat brain. Optogenetic stimulation of Chronos-expressing AI neurons suppressed DMN activity, and decreased AI-DMN and intra-DMN functional connectivity. Our findings demonstrate that feedforward optogenetic stimulation of AI neurons induces dynamic suppression and decoupling of the DMN and elucidates previously unknown features of rodent brain network organization. Our study advances foundational knowledge of causal mechanisms underlying dynamic cross-network interactions and brain network switching.

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Section: Discussionmentioning

confidence: 99%

Optogenetic stimulation of anterior insular cortex neurons in male rats reveals causal mechanisms underlying suppression of the default mode network by the salience network

et al. 2023

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“…Relatedly, they were proposed to control changing levels of attention through cortical activation 6,9,21 . BFPVNs were also suggested to activate the default mode network, which is likely responsible for maintaining global oscillatory activity necessary for higher cognitive functions and conscious experience in humans, determining the significance of which will require future studies 72,73 . Combining these and our results, we speculate that BFPVNs may rapidly activate limbic areas upon aversive stimuli to facilitate learning from negative experience.…”

Section: Discussionmentioning

confidence: 99%

Parvalbumin-expressing basal forebrain neurons mediate learning from negative experience

Hegedűs

Lyakhova

Velencei

et al. 2023

Preprint

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Parvalbumin (PV)-expressing GABAergic neurons of the basal forebrain (BFPVNs) were proposed to serve as a rapid and transient arousal system. While they have a well-documented role in the regulation of sleep-wake states, whether and how BFPVNs participate in mediating awake behaviors is not known. To address this, we performed bulk calcium imaging and recorded single neuronal activity from the horizontal band of the diagonal band of Broca (HDB) while mice were performing an associative learning task. Genetically identified BFPVNs of the HDB responded with a distinctive, phasic activation to punishment. In contrast, reward only elicited slow and delayed responses, while stimuli predicting behavioral reinforcement (reward or punishment) were followed by a gradual increase of HDB BFPVN firing rates. Optogenetic inhibition of HDB BFPVNs during punishment impaired the formation of cue-outcome associations, suggesting a causal role of these neurons in associative learning. Mapping the input-output connectivity of HDB BFPVNs by anterograde and mono-transsynaptic retrograde tracing experiments showed that these neurons received strong inputs from the hypothalamus, the septal complex and the median raphe region, while they synapsed on diverse cell types in key structures of the limbic system including the medial septum, the retrosplenial cortex and the hippocampus. Bulk calcium imaging performed in these termination regions indicated that HDB BFPVNs broadcast information about aversive stimuli to multiple downstream targets. We propose that the arousing effect of BFPVNs is recruited by aversive stimuli to serve crucial associative learning functions during awake behaviors.

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“…15 Additional studies have also identified the role of the DMN in complex cognitive processes such as memory, sensory integration, and visual integration. 16 A significant amount of clinical interest in the DMN has developed because of its observable relationship with various brain diseases and nonpathological aspects of aging and neurodevelopment. 17 18 The DMN is involved in mental representations of the self and others, and disruptions in its connectivity are associated with changes in social and emotional processing that occur in disorders such as posttraumatic stress disorder, autism spectrum disorder, and schizophrenia.…”

Section: Default Mode Networkmentioning

confidence: 99%

Connectomic Networks and Their Impact on Clinical Outcomes in Glioma Treatment: A Review

Rawanduzy

Earl

Brooks

et al. 2023

Indian Journal of Neurosurgery

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The emerging field of connectomics has provided an improved understanding of the structural and functional organization of the human brain into large-scale brain networks. Recent studies have helped define the canonical neurological networks and outline how considering their presence may aid in surgical decision-making in brain tumor patients. Gliomas represent one of the most common types of brain tumor and often involve displacement and/or infiltration of neurological pathways, suggesting an opportunity to use connectomic maps to improve patient morbidity and mortality based on oncofunctional goals. This review aims to provide a working knowledge of important neurological networks, examine the use of networks in surgical planning, and describe the current literature discussing the impact of these networks on clinical outcomes in glioma resection.

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Subcortical control of the default mode network: Role of the basal forebrain and implications for neuropsychiatric disorders

Cited by 13 publications

References 137 publications

Optogenetic stimulation of anterior insular cortex neurons in male rats reveals causal mechanisms underlying suppression of the default mode network by the salience network

Optogenetic stimulation of anterior insular cortex neurons in male rats reveals causal mechanisms underlying suppression of the default mode network by the salience network

Parvalbumin-expressing basal forebrain neurons mediate learning from negative experience

Connectomic Networks and Their Impact on Clinical Outcomes in Glioma Treatment: A Review

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