Subcortical connectivity in dementia with Lewy bodies and Alzheimer's disease

Kenny, Eva; O’Brien, John T.; Firbank, Michael; Blamire, Andrew M.

doi:10.1192/bjp.bp.112.108464

Cited by 37 publications

(58 citation statements)

References 46 publications

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“…This finding contrasts with reported connectivity dysfunctions between the posterior and anterior portions of the default mode network in AD [48]. Kenny and colleagues [49] found greater connectivity between the putamen and frontal, temporal and parietal regions in DLB patients compared with AD patients, and argued that this might be associated with Parkinsonian features in DLB. Consistent with relative preservation of memory function in DLB compared with AD, hippocampal connectivity was not found to be different in DLB compared to healthy controls.…”

Section: Functional Mrimentioning

confidence: 67%

Neuroimaging characteristics of dementia with Lewy bodies

Mak

Williams³

et al. 2014

Alzheimers Res Ther

100

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This review summarises the findings and applications from neuroimaging studies in dementia with Lewy bodies (DLB), highlighting key differences between DLB and other subtypes of dementia. We also discuss the increasingly important role of imaging biomarkers in differential diagnosis and outline promising areas for future research in DLB. DLB shares common clinical, neuropsychological and pathological features with Parkinson’s disease dementia and other dementia subtypes, such as Alzheimer’s disease. Despite the development of consensus diagnostic criteria, the sensitivity for differential diagnosis of DLB in clinical practice remains low and many DLB patients will be misdiagnosed. The importance of developing accurate imaging markers in dementia is highlighted by the potential for treatments targeting specific molecular abnormalities as well as the responsiveness to cholinesterase inhibitors and marked neuroleptic sensitivity of DLB. We review various brain imaging techniques that have been applied to investigate DLB, including the characteristic nigrostriatal degeneration in DLB using positron emission tomography (PET) and single-photon emission computed tomography (SPECT) tracers. Dopamine transporter loss has proven to reliably differentiate DLB from other dementias and has been incorporated into the revised clinical diagnostic criteria for DLB. To date, this remains the 'gold standard' for diagnostic imaging of DLB. Regional cerebral blood flow, 18 F-fluorodeoxygluclose-PET and SPECT have also identified marked deficits in the occipital regions with relative sparing of the medial temporal lobe when compared to Alzheimer’s disease. In addition, structural, diffusion, and functional magnetic resonance imaging techniques have shown alterations in structure, white matter integrity, and functional activity in DLB. We argue that the multimodal identification of DLB-specific biomarkers has the potential to improve ante-mortem diagnosis and contribute to our understanding of the pathological background of DLB and its progression.

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Section: Functional Mrimentioning

confidence: 67%

Neuroimaging characteristics of dementia with Lewy bodies

Mak

Williams³

et al. 2014

Alzheimers Res Ther

100

View full text Add to dashboard Cite

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“…Another novel MRI technique is resting-state functional MRI, which measures brain function by functional connectivity at rest. Several studies have shown that functional connectivity is altered in patients with MCI and AD [65]-[69], but again, robust longitudinal data are still lacking. Moreover, the role of cardiovascular risk factors in functional MRI remains unclear.…”

Section: Reviewmentioning

confidence: 99%

Cardiovascular risk factors and future risk of Alzheimer’s disease

Bruijn

Ikram

2014

BMC Med

275

185

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Alzheimer’s disease (AD) is the most common neurodegenerative disorder in elderly people, but there are still no curative options. Senile plaques and neurofibrillary tangles are considered hallmarks of AD, but cerebrovascular pathology is also common. In this review, we summarize findings on cardiovascular disease (CVD) and risk factors in the etiology of AD. Firstly, we discuss the association of clinical CVD (such as stroke and heart disease) and AD. Secondly, we summarize the relation between imaging makers of pre-clinical vascular disease and AD. Lastly, we discuss the association of cardiovascular risk factors and AD. We discuss both established cardiovascular risk factors and emerging putative risk factors, which exert their effect partly via CVD.

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“…Many studies have evidenced noradrenergic, dopaminergic, or cholinergic denervation in the thalamus of patients with PD and DLB 171–173. Prominent thalamic degeneration and denervation have also been observed in C9ORF72 FTD 60,63.…”

Section: Hypothesismentioning

confidence: 99%

Psychosis in parkinsonism: an unorthodox approach

Onofrj

Carrozzino

D’Amico

et al. 2017

NDT

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Psychosis in Parkinson’s disease (PD) is currently considered as the occurrence of hallucinations and delusions. The historical meaning of the term psychosis was, however, broader, encompassing a disorganization of both consciousness and personality, including behavior abnormalities, such as impulsive overactivity and catatonia, in complete definitions by the International Classification of Diseases-10 (ICD-10) and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Our review is aimed at reminding that complex psychotic symptoms, including impulsive overactivity and somatoform disorders (the last being a recent controversial entity in PD), were carefully described in postencephalitic parkinsonism (PEP), many decades before dopaminergic treatment era, and are now described in other parkinsonisms than PD. Eminent neuropsychiatrists of the past century speculated that studying psychosis in PEP might highlight its mechanisms in other conditions. Yet, functional assessments were unavailable at the time. Therefore, the second part of our article reviews the studies of neural correlates of psychosis in parkinsonisms, by taking into account both theories on the narrative functions of the default mode network (DMN) and hypotheses on DMN modulation.

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Subcortical connectivity in dementia with Lewy bodies and Alzheimer's disease

Abstract: Altered connectivity in DLB and Alzheimer's disease provides new insights into the neurobiology of these disorders and may aid in earlier diagnosis.

Cited by 37 publications

References 46 publications

Neuroimaging characteristics of dementia with Lewy bodies

Neuroimaging characteristics of dementia with Lewy bodies

Cardiovascular risk factors and future risk of Alzheimer’s disease

Psychosis in parkinsonism: an unorthodox approach

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