Subcorneal pustular dermatosis

Subcorneal Pustular Dermatosis Treated with PUVA Therapy

“…It is a chronic benign relapsing pustular eruption mainly involving the trunk and affecting particularly women over 40 years of age. A few cases have been reported in children [1, 9]. …”

“…SPD was first described by Sneddon and Wilkinson [1, 10]. It is a chronic benign relapsing pustular eruption mainly involving the trunk and affecting particularly women over 40 years of age.…”

“…The lesions are mainly located on the trunk, the proximal extremities and the flexor aspect of the limbs. Palms and soles are seldom affected, whereas manifestation on the face or in mucous membranes have yet to be observed [1]. Cultures of the pustules are sterile [1].…”

“…Treatments including antibiotics [9], estrogen [9], niacin [9], colchicine [2], vitamin E, corticosteroids [9], etretinate [2, 9], diaminodiphenylsulphone (dapsone) [1, 2, 9, 10], sulfapyridine [2, 10]and PUVA [2]have been proposed. However, none of these drugs has been uniformly successful.…”

“…This dermatosis may be associated with a large number of diseases such as benign and malignant monoclonal gammopathies [1, 2, 3, 4, 5, 6], colitis ulcerosa, pyoderma gangrenosum [5], leukocytoclastic vasculitis, systemic lupus erythematosus [7]and rheumatoid-like arthritis [8]. …”