Subcommissural organ/Reissner's fiber complex: Characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth

Gobron, Stéphane; Creveaux, Isabelle; Meiniel, R; Didier, Robert; Herbet, A.; Bamdad, Mahchid; Bitar, Fadia El; Dastugue, B.; Meiniel, Annie

doi:10.1002/1098-1136(200011)32:2<177::aid-glia70>3.0.co;2-v

Cited by 75 publications

(74 citation statements)

References 49 publications

(45 reference statements)

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“…A role for SCO-spondin in the formation of the PC has been widely proposed (Gobron et al, 2000;Meiniel, 2001;Ferná ndez-Llebrez et al, 2001;Lehmann and Naumann, 2005). This notion is supported by the following evidence: (i) SCO-spondin shares similarities with proteins involved in axonal guidance, (ii) this protein is expressed by the SCO before PC formation, (iii) SCO-spondin promotes neuritic outgrowth in vitro, and (iv) defective SCO differentiation correlates with impaired PC development.…”

Section: Discussionmentioning

confidence: 79%

“…Mutations in genes that regulate the development of prosomere 1, including Pax2/5, Pax6, and Msx-1 proteins, display a wide range of abnormalities in the development of the SCO that are highly similar to the phenotypes observed in the PC (Schwarz et al, 1999;Estivil-Torrus et al, 2001;Ferná ndez-LLebrez et al, 2004;Ramos et al, 2004). On the other hand, peptides containing the TSR motifs of SCO-spondin interfere with a variety of neuronal processes in vitro, including neuronal survival, neurite outgrowth, and fasciculation (Gobron et al, 1996(Gobron et al, , 2000Monnerie et al, 1998;Meiniel, 2001;Meiniel et al, 2003). Although these results suggest a role for the SCO and its secretory product, SCO-spondin, in the formation of the PC, the molecules and mechanisms that mediate this effect are poorly understood.…”

Section: Introductionmentioning

confidence: 93%

“…A functional relationship between the SCO and the development of the PC has been proposed (Gobron et al, 2000;Meiniel, 2001;Ferná ndez-Llebrez et al, 2001;Lehmann and Naumann, 2005). Mutations in genes that regulate the development of prosomere 1, including Pax2/5, Pax6, and Msx-1 proteins, display a wide range of abnormalities in the development of the SCO that are highly similar to the phenotypes observed in the PC (Schwarz et al, 1999;Estivil-Torrus et al, 2001;Ferná ndez-LLebrez et al, 2004;Ramos et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…In the few studies related to the basal secretion (Losecke et al, 1984(Losecke et al, , 1986Biosca and Azcoitia, 1989;Rodríguez et al, 1984a,b;Peruzzo et al, 1990), the authors performed studies in adult animals, and concluded that basal secretion of SCO-spondin was probably toward the blood vessels or toward the subarachnoidal space. Nonetheless, despite the fact that SCO-spondin has been suggested to play a role in PC development (Gobron et al, 2000;Meiniel, 2001;Ferná ndez-Llebrez et al, 2001;Lehmann and Naumann, 2005), there are no reports addressing the basal secretion of this protein toward the extracellular matrix that surrounds the axons of the PC at embryonic stages.…”

Section: Introductionmentioning

confidence: 99%

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Polarized expression of integrin β1 in diencephalic roof plate during chick development, a possible receptor for SCO‐spondin

Caprile

Osorio

Henríquez

et al. 2009

Developmental Dynamics

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The roof plate of the caudal diencephalon is formed by the posterior commissure (PC) and the underlying secretory ependyma, the subcommissural organ (SCO). The SCO is composed by radial glial cells bearing processes that cross the PC and attach to the meningeal basement membrane. Since early development, the SCO synthesizes SCO-spondin, a glycoprotein that shares similarities to axonal guidance proteins. In vitro, SCO-spondin promotes neuritic outgrowth through a mechanism mediated by integrin ␤1. However, the secretion of SCO-spondin toward the extracellular matrix that surrounds the PC axons and the expression of integrins throughout PC development have not been addressed. Here we provide immunohistochemical evidence to suggest that during chick development SCO cells secrete SCO-spondin through their basal domain, where it is deposited into the extracellular matrix in close contact with axons of the PC that express integrin ␤1. Our results suggest that SCO-spondin has a role in the development of the PC through its interaction with integrin ␤1.

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Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Polarized expression of integrin β1 in diencephalic roof plate during chick development, a possible receptor for SCO‐spondin

Caprile

Osorio

Henríquez

et al. 2009

Developmental Dynamics

View full text Add to dashboard Cite

show abstract

“…108 Besides the full-length canonical form, SCO-spondin has an alternatively spliced isoform #2 (UniProt ID: A2VEC9-2) whose shortened sequence (1,314 residues) originates from removal of long N-and C-terminal regions (residues 1-1122 and 2315-5147, respectively), changes of Ala 1639 to ACVEAPAPPA… DCPQGEDELD, changes of Leu 1671 to LVRVGVGGGGGSAMLPPSTRALTPLPPQ, and by substituting the 2179-2314 region LFPRNWDDLD… ETEHWPPGQE to VSPAQGRWGQ…RSGRNQSVLC.…”

Section: Sco-spondinmentioning

confidence: 99%

Intrinsic disorder in spondins and some of their interacting partners

Alowolodu

Johnson

Alashwal

et al. 2016

Intrinsically Disordered Proteins

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Spondins, which are proteins that inhibit and promote adherence of embryonic cells so as to aid axonal growth are part of the thrombospondin-1 family. Spondins function in several important biological processes, such as apoptosis, angiogenesis, etc. Spondins constitute a thrombospondin subfamily that includes F-spondin, a protein that interacts with Ab precursor protein and inhibits its proteolytic processing; R-spondin, a 4-membered group of proteins that regulates Wnt pathway and have other functions, such as regulation of kidney proliferation, induction of epithelial proliferation, the tumor suppressant action; M-spondin that mediates mechanical linkage between the muscles and apodemes; and the SCO-spondin, a protein important for neuronal development. In this study, we investigated intrinsic disorder status of human spondins and their interacting partners, such as members of the LRP family, LGR family, Frizzled family, and several other binding partners in order to establish the existence and importance of disordered regions in spondins and their interacting partners by conducting a detailed analysis of their sequences, finding disordered regions, and establishing a correlation between their structure and biological functions.

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SCO-spondin, a glycoprotein of the subcommissural organ/reissner's fiber complex: Evidence of a potent activity on neuronal development in primary cell cultures

Subcommissural organ/Reissner's fiber complex: Characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth

Cited by 75 publications

References 49 publications

Polarized expression of integrin β1 in diencephalic roof plate during chick development, a possible receptor for SCO‐spondin

Polarized expression of integrin β1 in diencephalic roof plate during chick development, a possible receptor for SCO‐spondin

Intrinsic disorder in spondins and some of their interacting partners

SCO-spondin, a glycoprotein of the subcommissural organ/reissner's fiber complex: Evidence of a potent activity on neuronal development in primary cell cultures

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