Subclinical Visual Involvement in Multiple Sclerosis: A Study by MRI, VEPs, Frequency-Doubling Perimetry, Standard Perimetry, and Contrast Sensitivity

Sisto, Dario; Trojano, María; Vetrugno, Michele; Trabucco, Tiziana; Iliceto, Giovanni; Sborgia, Carlo

doi:10.1167/iovs.03-1213

Cited by 108 publications

(92 citation statements)

References 18 publications

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“…Some studies have shown the presence of subclinical optic neuropathy in MS patients, which can be diagnosed by performing not only OCT, but such multiple tests as visual evoked potentials, visual field examination, visual acuity, and colour vision. [25][26][27] According to the literature, in the early stages of ON in MS patients, RNFL and macular thinning or thickening (swelling) can occur, along with different structural changes in optic disc morphology. 27,28 The retina in MS patients passes through stages of minimal demyelination, remyelination, and gliosis, which can be verified only by biopsy.…”

Section: Discussionmentioning

confidence: 99%

Optical Coherence Tomography in Patients with Relapsing-Remitting Multiple Sclerosis without Optic Neuritis: A 20-Month Longitudinal Study

Huseyinoglu¹,

Özben²,

Ekinci

et al. 2013

Neuro-Ophthalmology

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Optical coherence tomography is supported and used as a technique for visualisation of neuro-axonal loss in multiple sclerosis, but there are also a few studies expressing the opposite view. The aim of our study was to investigate retinal nerve fibre layer and optic nerve head parameters in patients with multiple sclerosis without a history of prior optic neuritis and symptoms of a new clinical attack during the follow-up for a total of 20-month period. Full ophthalmic evaluation was performed for all of the participants. The baseline retinal nerve fibre layer and macular thicknesses and focal and global loss of macular volume values were significantly lower in the eyes of the patients with multiple sclerosis compared with the healthy controls. No significant change between baseline and follow-up scans were found in all optical coherence tomography parameters in the multiple sclerosis group. Statistical analyses revealed significant retinal nerve fibre layer and macular thickness differences between baseline and second measurements in the controls. No significant difference in percent change between baseline and second measurements was observed between the patient and control groups. We conclude that whereas healthy subjects have an age-related tendency toward a decrease in retinal nerve fibre layer thickness, patients with multiple sclerosis patients are likely to pass through different stages of retinal thinning and thickening due to subclinical optic neuritis and, as a result, we could not detect any statistically significant change between baseline and second measurements in our multiple sclerosis patients.

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Section: Discussionmentioning

confidence: 99%

Optical Coherence Tomography in Patients with Relapsing-Remitting Multiple Sclerosis without Optic Neuritis: A 20-Month Longitudinal Study

Huseyinoglu¹,

Özben²,

Ekinci

et al. 2013

Neuro-Ophthalmology

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“…In fact, the common conclusion is that MS patients have more visual complaints and a variety of ophthalmological abnormalities that warrant comprehensive examination. As reported by Sisto et al 24 , no single ophthalmic test would be able to detect all the subclinical abnormalities present in MS eyes. The recent work of Mowry et al 25 also points towards the use of different and meaningful ophthalmological measures in order to better interpret the visual impairment and visual-related quality of life in MS.…”

Section: Resultsmentioning

confidence: 88%

Sight-dependent quality of life and ophthalmic findings in a group of Brazilian patients with multiple sclerosis

Fragoso

Nosé

Nosé³

et al. 2011

Arq. Neuro-Psiquiatr.

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Objective: To assess the visual quality of life in patients with multiple sclerosis (MS), and to observe whether this parameter could be correlated to the findings of the ophthalmologic examination. Method: The translated and validated 25-Item National Eye Institute Visual Function Questionnaire (VFQ-25) was used to assess the visual quality of life. Clinical data on MS, visual acuity, visual fields, optic coherence tomography (OCT) and disc cupping were used for assessing correlation with VFQ-25. Results: The mean VFQ-25 value was 78.6±18.2% in 27 patients. VFQ-25 did not correlate with patients' ages, with disability (EDSS), disease duration or medication use. Visual acuity showed a relatively poor (<60%) correlation to VFQ-25, while no correlation could be established between visual fields, OCT and disc cupping with VFQ-25. Conclusion: MS patients present several alterations in their eyes and sight that cannot be assessed by isolated measures. Ophthalmological examination of these patients must include many parameters not usually used in standard ophthalmologic consultations. Key words: multiple sclerosis, ophthalmology, visual acuity, visual fields, optic coherence tomography, quality of life.Qualidade de vida visual e achados oftálmicos em um grupo de pacientes brasileiros com esclerose múltipla RESUMO Objetivo: Avaliar a qualidade de vida visual de pacientes com esclerose múltipla (EM) e observar se este parâmetro pode ser relacionado aos achados do exame oftalmológico. Método: O questionário traduzido e validado 25-Item National Eye Institute Visual Function Questionnaire (VFQ-25) foi utilizado para avaliar a qualidade de vida visual. Dados clínicos da EM, acuidade visual, campo visual, tomografia de coerência óptica (OCT) e escavação do disco foram utilizados para correlação com VFQ-25. Resultados: A média do VFQ-25 foi 78,6±18,2% em 27 pacientes. VFQ-25 não se correlacionou com a idade dos pacientes, com a incapacidade (EDSS), duração da doença ou medicação em uso. A acuidade visual mostrou uma correlação relativamente pobre (<60%) com VFQ-25, enquanto não foi observada nenhuma correlação entre campo visual, OCT e escavação de disco com VFQ-25. Conclusão: Pacientes com EM apresentam diversas alterações oculares e na visão que não podem ser avaliadas por medidas isoladas. O exame oftalmológico destes pacientes deve incluir parâmetros que não são habitualmente utilizados em consultas oftalmológicas padronizadas. Palavras-Chave: esclerose múltipla, oftalmologia, acuidade visual, campo visual, tomografia de coerência óptica, qualidade de vida.

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“…Hastalarda genelikle MD değişikliklerinde geniş prevelansın eşlik ettiği diffüz tip kayıpla birlikte daha az oranda santral 10° ve 20°'ye uzanan merkezi depresyon, derin santral skotom, parsiyel sağ homonim hemianopsi, parsiyel sol homonim hemianopsi tarzında görme alanı defektleri bildirmişlerdir. 19 Çalışmamızda MD ve PSD değerlerinde kontrol grubu ile diğer gruplar arasında istatistiksel olarak anlamlı bir fark mevcuttu. MD ve PSD düzeyindeki değişikliklere %80 oranında diffüz tip GA kaybı eşlik etmekteydi.…”

Section: Discussionunclassified

Subklinik Multipl Skleroz Hastalarının Desen Görsel Uyarılmış Potansiyeller ve Görme Alanı Testi ile Değerlendirilmesi

Bilgin¹,

İlker²,

Çavdar³

et al. 2014

tjo

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Subclinical Visual Involvement in Multiple Sclerosis: A Study by MRI, VEPs, Frequency-Doubling Perimetry, Standard Perimetry, and Contrast Sensitivity

Cited by 108 publications

References 18 publications

Optical Coherence Tomography in Patients with Relapsing-Remitting Multiple Sclerosis without Optic Neuritis: A 20-Month Longitudinal Study

Optical Coherence Tomography in Patients with Relapsing-Remitting Multiple Sclerosis without Optic Neuritis: A 20-Month Longitudinal Study

Sight-dependent quality of life and ophthalmic findings in a group of Brazilian patients with multiple sclerosis

Subklinik Multipl Skleroz Hastalarının Desen Görsel Uyarılmış Potansiyeller ve Görme Alanı Testi ile Değerlendirilmesi

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