Subclinical Retinal Capillary Abnormalities in Juvenile Systemic Lupus Erythematosus without Ocular Involvement

Tuğan, Büşra Yılmaz; Sönmez, Hafize Emine; Yüksel, Nurşen; Karabaş, Levent

doi:10.1080/09273948.2022.2116584

Cited by 5 publications

(8 citation statements)

References 28 publications

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“…10 A similar decrease in SCP vessel density in SLE patients without ocular involvement was also observed by Bao et al 11 At present, only one Turkey study has included 10 patients with JSLE without ocular involvement. 12 However, no significant difference in SCP vessel density was found, which is inconsistent with our results. The small sample size of their study may account for this difference.…”

Section: Discussioncontrasting

confidence: 99%

“…14,19 Tugan et al did not find any differences in the FAZ area between the children with JSLE and the control group, which is consistent with our research results. 12 SLEDAI is an indicator for evaluating disease activity. It has been reported that retinopathy may be more common in patients with active inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…14 Tuğan et al also reported that DCP in all quadrants of children with JSLE decreased compared with the normal control group. 12 Thanks to system optimization, the OCTA used in our study can further subdivide previous deep retinal blood flow into ICP and DCP. We have reported for the first time a decrease in VD of ICP in JSLE patients.…”

Section: Discussionmentioning

confidence: 99%

“…No significant difference in CC vessel density was observed by Tuğan et al between JSLE patients and the control group. 12 However, some researchers have reported a decrease in CC blood flow in adult SLE patients. 7 Our study found that CC vessel density significantly decreased in JSLE patients.…”

Section: Discussionmentioning

confidence: 99%

“…14,19 Tuğan et al did not find any differences in the FAZ area between the children with JSLE and the control group, which is consistent with our research results. 12…”

Section: Discussionmentioning

confidence: 99%

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Subclinical macular vessel density alterations in patients with juvenile systemic lupus erythematosus

Xu,

Zhang

2023

Lupus

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Objective The aim is to evaluate subclinical alterations of macular microvasculature in patients with juvenile systemic lupus erythematosus (JSLE). Methods This is a cross-sectional study of 29 eyes of 29 patients diagnosed with JSLE and 29 eyes of 29 healthy controls. The vessel density (VD) of the superficial capillary plexus (SCP), intermediate capillary plexus (ICP), deep capillary plexus (DCP), choriocapillaris (CC), and area of foveal avascular zone (FAZ) was measured using optical coherence tomography angiography (OCTA). A multiple linear regression analysis was performed to evaluate the effects of disease duration and activity on OCTA parameters. Results The VD of total ( p = .007) and the superior ( p = .014) and inferior ( p = .004) quadrants in SCP was significantly lower in children with JSLE. The VD of total and all quadrants in ICP decreased ( p = .015, p = .0045, p = .015, p = .033), except that of the temporal quadrant ( p = .366). The total ( p = .011) and superior quadrant ( p<.01) DCP-VD showed a significant decrease in children with JSLE. The decrease in VD in the total ( p = .003) and nasal quadrant ( p = .017) of CC was also remarkable. No significant difference in the FAZ area was found between the two groups ( p = .774). Multiple linear regression analyses adjusted for age, spherical equivalent, and intraocular pressure were conducted. No contributing factor to OCTA parameters was found. Conclusions We demonstrated decreased VD in all layers of the retina and CC in patients with JSLE without ocular involvement. Early screening and close follow-up were recommended.

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confidence: 99%

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confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…14,19 Tuğan et al did not find any differences in the FAZ area between the children with JSLE and the control group, which is consistent with our research results. 12…”

Section: Discussionmentioning

confidence: 99%

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