Subclinical Inflammation Is Associated With Reductions in Muscle Oxygenation, Exercise Capacity and Quality of Life in Adults With Type 2 Diabetes

Bozdemir-Özel, Cemile; Arıkan, Hülya; Çalık-Kütükçü, Ebru; Karadüz, Beyza Nur; Inal-Ince, Deni̇z; Kabakçı, Giray; Sumer, Erkan; Dağdelen, Selçuk

doi:10.1016/j.jcjd.2020.02.007

Cited by 1 publication

(1 citation statement)

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“…Metal exposure and duration was also correlated to arterial hypertension as a result of increased oxidative stress [23]. Exercise capacity, muscle oxygenation and the psychological impact are negatively associated with higher C-reactive protein levels, indicating poorer quality of life for subjects with higher CRP concentrations [24]. High levels of effort, over-commitment and effort-reward imbalance at work increase CRP levels significantly in both sexes and link job stress and stress-related diseases such as atherosclerosis [25,26].…”

Section: Discussionmentioning

confidence: 99%

Occupational Health Aspects with Special Focus on Physiological Differences between Office and Metalworkers

et al. 2022

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Physical workload adversely impacts inflammation, oxidative stress and mood in heavy workers. We compared these risk parameters between metalworkers (n = 20) and office workers (n = 30), including gender differences. Blood samples were analyzed with thirty parameters to overview endocrinology, inflammation, and psychological and oxidative stress. Despite an adequate antioxidative supply, oxidative stress occurred in metalworkers, as indicated by significantly increased peroxide and homocysteine (Hcy) levels. Moreover, increased concentrations were observed in this group regarding psychological stress and diet-related parameters. Sex-specific differences were determined for physical dimensions, dehydroepiandrosterone sulfate (DHEAS), Hcy, uric acid, triglycerides, osmolality, anti-Mullerian hormone (AMH) and testosterone. Age-associated differences were observed for DHEAS, glycosylated hemoglobin, adrenaline, AMH and testosterone. In male office workers, the body mass index was associated with increased LDL-HDL, cholesterol-HDL and homeostatic model assessment of insulin resistance (HOMA-IR). In conclusion, these results indicate increased oxidative stress and psychological stress in heavy workers independently of adequate antioxidant sustenance. The sedentary occupation of office workers, in turn, favored diseases of affluence. This might be particularly relevant for long-term occupied persons and older workers due to a hormonal shift coming along, given the risk for oxidative stress-related diseases such as cardiovascular disease, particularly in the case of males, based on their lifestyle habits.

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