Subclinical impairment of arterial mechanics in systemic lupus erythematosus identified by arterial waveform analysis

Wright, Stephen; O'Prey, F; Rea, Derrick J.; McHenry, Michelle; Johnston, Dennis; McGivern, R. C.; Finch, M B; Bell, A. L.; McVeigh, Gary E.

doi:10.1007/s00296-007-0327-4

Cited by 5 publications

(6 citation statements)

References 41 publications

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“…Increased PWV, a marker of adverse cardiovascular prognosis in various adult populations (5), has been demonstrated in adult CID patients (11, 32) and children at high cardiovascular risk (7, 33). LAEI and SAEI are relatively novel markers of arterial compliance that have been associated with cardiovascular risk factors (34, 35) and CID in adults (36), but their value in cardiovascular prognosis is not known. No previous studies assessed LAEI and SAEI in patients with JIA.…”

Section: Discussionmentioning

confidence: 99%

Long‐term effects of differential early rearing in rhesus macaques: Behavioral reactivity in adulthood

Corcoran

Pierre

Haddad

et al. 2011

Developmental Psychobiology

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Adverse early experiences are associated with a range of deleterious health outcomes in humans, including higher risk for affective disorders. Studies using a long-standing model of nonhuman primate model of early adversity have demonstrated that nursery-reared monkeys exhibit alterations in multiple aspects of biobehavioral development; however, few studies have evaluated the persistence of socioaffective behavioral changes through adulthood. We evaluated the effects of early rearing experience on adult animals’ response to a well-validated assessment of anxiety-like behavior, the Human Intruder Paradigm (HIP). We tested twenty-two rhesus monkeys who were either nursery-reared (NR) or reared with their mothers (mother-reared; MR). NR monkeys were inhibited in their behavior compared to MR monkeys, with reduced locomotion and exploratory behaviors. NR animals showed a marginal increase in freezing. Together these findings demonstrate that the consequences of differential infant rearing experience on socioaffective behavior persist into adulthood, with evidence of greater inhibition in NR monkeys.

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Section: Discussionmentioning

confidence: 99%

Long‐term effects of differential early rearing in rhesus macaques: Behavioral reactivity in adulthood

Corcoran

Pierre

Haddad

et al. 2011

Developmental Psychobiology

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“…Increased PWV, a marker of adverse cardiovascular prognosis in various adult populations (5), has been demonstrated in adult CID patients (11,32) and children at high cardiovascular risk (7,33). LAEI and SAEI are relatively novel markers of arterial compliance that have been associated with cardiovascular risk factors (34,35) and CID in adults (36), but their value in cardiovascular prognosis is not known. No previous studies assessed LAEI and SAEI in patients with JIA.…”

Section: Discussionmentioning

confidence: 99%

Changes in vascular function and structure in juvenile idiopathic arthritis

Vlahos¹,

Theocharis²,

Bechlioulis³

et al. 2011

Arthritis Care & Research

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Objective. Chronic inflammatory diseases in adults have been associated with increased cardiovascular risk and impaired vascular function. We aimed to assess the presence of early vascular dysfunction in patients with juvenile idiopathic arthritis (JIA) and investigate the role of inherent inflammatory process of JIA in vascular health. Methods. Thirty patients with JIA (age range 7-18 years) were compared to 33 age-and sex-matched controls. Endothelial function (brachial artery flow-mediated dilation [FMD]), carotid intima-media thickness (IMT), and arterial stiffness were examined. Endothelial inflammation was assessed by intercellular adhesion molecule 1 (ICAM-1) and P-selectin measurements. Results. Patients with JIA showed decreased FMD compared to controls (P ‫؍‬ 0.001), independent of age (P ‫؍‬ 0.9 among age subgroups). Baseline differences in erythrocyte sedimentation rate, ICAM-1, and glucose between the 2 groups accounted for the difference in FMD. The presence of systemic JIA was associated with greater IMT compared to patients with oligoarticular disease, polyarticular disease, or controls (P ‫؍‬ 0.014, P ‫؍‬ 0.069, and P ‫؍‬ 0.046, respectively). The difference in IMT between systemic versus oligoarticular/polyarticular JIA was attributed to the following risk factors: age, body mass index, blood pressure, disease activity, and corticosteroids use. There were no differences in arterial stiffness indices between JIA patients and controls or between patients with systemic versus nonsystemic disease. Conclusion. Endothelial function is impaired in patients with JIA at a very young age, while IMT is increased only in the presence of systemic JIA. Vascular dysfunction may be partly attributed to the effects of disease-related characteristics (inflammation, disease activity, and medications).

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“…8,9 Our group and others have shown that an alteration in arterial mechanics occurs in SLE and this finding may contribute to the development of atherosclerosis in these patients. 10,11 Furthermore, we have shown the potential importance of microcirculatory abnormalities in SLE with patients exhibiting impaired brachial artery flow-mediated dilation and altered microvascular responses to a period of forearm ischaemia. 12 Structural and functional changes in different vascular territories are known to provide predictive information in relation to arterial disease progression and future micro-and macro-vascular complications.…”

Section: Introductionmentioning

confidence: 89%

Colour Doppler ultrasound of the ocular circulation in patients with systemic lupus erythematosus identifies altered microcirculatory haemodynamics

Wright

O’Prey²,

Hamilton³

et al. 2009

Lupus

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We assessed whether quantitative analysis of Doppler flow velocity waveforms is able to identify subclinical microvascular abnormalities in SLE and whether eigenvector analysis can detect changes not detectable using the resistive index (RI). Fifty-four SLE patients with no conventional cardiovascular risk factors, major organ involvement or retinopathy were compared to 32 controls. Flow velocity waveforms were obtained from the ophthalmic artery (OA), central retinal artery (CRA) and common carotid artery (CA). The waveforms were analysed using eigenvector decomposition and compared between groups at each arterial site. The RI was also determined. The RI was comparable between groups. In the OA and CRA, there were significant differences in the lower frequency sinusoidal components (P < 0.05 for each component). No differences were apparent in the CA between groups. Eigenvector analysis of Doppler flow waveforms, recorded in proximity of the terminal vascular bed, identified altered ocular microvascular haemodynamics in SLE. Altered waveform structure could not be identified by changes in RI, the traditional measure of downstream vascular resistance. This analytical approach to waveform analysis is more sensitive in detecting preclinical microvascular abnormalities in SLE. It may hold potential as a useful tool for assessing disease activity, response to treatment, and predicting future vascular complications.

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Subclinical impairment of arterial mechanics in systemic lupus erythematosus identified by arterial waveform analysis

Cited by 5 publications

References 41 publications

Long‐term effects of differential early rearing in rhesus macaques: Behavioral reactivity in adulthood

Long‐term effects of differential early rearing in rhesus macaques: Behavioral reactivity in adulthood

Changes in vascular function and structure in juvenile idiopathic arthritis

Colour Doppler ultrasound of the ocular circulation in patients with systemic lupus erythematosus identifies altered microcirculatory haemodynamics

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