2012
DOI: 10.1530/eje-12-0015
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Subclinical hyperthyroidism and the risk of cardiovascular events and all-cause mortality: an updated meta-analysis of cohort studies

Abstract: Objectives: Whether subclinical hyperthyroidism (SCH) results in poor prognosis remains controversial. Our aim was to evaluate the association between SCH and the risk of cardiovascular disease (CVD), cardiovascular mortality, and all-cause mortality by conducting a meta-analysis of cohort studies. Methods: The PubMed and Embase databases were searched through November 2011 to identify studies that met pre-stated inclusion criteria. Relevant information for analysis was extracted. Either a fixed or a random ef… Show more

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Cited by 49 publications
(38 citation statements)
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“…In contrast, our results are essentially in agreement with more recent meta-analyses that reported up to 41% and 20% increased risk of all-cause mortality in subclinical and overt hyperthyroid subjects, respectively (1,25,26). Likewise, a further and large meta-analysis of 17 cohorts demonstrated the same increased risk, but a subgroup analysis revealed that cardiovascular and all-cause mortality was increased only in individuals with existing comorbidity (27). On this specific item, our analyses did not agree because excluding individuals with known comorbidity did not change our results.…”
Section: Hyperthyroid Statessupporting
confidence: 93%
“…In contrast, our results are essentially in agreement with more recent meta-analyses that reported up to 41% and 20% increased risk of all-cause mortality in subclinical and overt hyperthyroid subjects, respectively (1,25,26). Likewise, a further and large meta-analysis of 17 cohorts demonstrated the same increased risk, but a subgroup analysis revealed that cardiovascular and all-cause mortality was increased only in individuals with existing comorbidity (27). On this specific item, our analyses did not agree because excluding individuals with known comorbidity did not change our results.…”
Section: Hyperthyroid Statessupporting
confidence: 93%
“…However, the updated meta-analyses of population cohort studies demonstrated a clear association of hyperthyroidism (even subclinical) with increased cardiovascular morbidity and mortality (14,15). From combined community-based studies, Yang et al (14) concluded that the general population with subclinical hyperthyroidism was at a 31% increased risk of cardiovascular disease.…”
Section: Discussionmentioning
confidence: 99%
“…However, the updated meta-analyses of population cohort studies demonstrated a clear association of hyperthyroidism (even subclinical) with increased cardiovascular morbidity and mortality (14,15). From combined community-based studies, Yang et al (14) concluded that the general population with subclinical hyperthyroidism was at a 31% increased risk of cardiovascular disease. As nearly all the studies were adjusted for conventional cardiovascular risk factors (age, BMI, blood pressure, diabetes, cholesterol and smoking), the results suggested that subclinical hyperthyroidism could be an independent risk factor for cardiovascular disease.…”
Section: Discussionmentioning
confidence: 99%
“…Five meta-analyses assessed the risk of cardiovascular and all-cause mortality in patients with SHyper [71,89,90,91,92,93]. Two did not find a link between SHyper and mortality [89,90], whereas four other meta-analyses found an association between SHyper and cardiovascular or all-cause mortality [71,91,92,93], especially in elderly patients and in patients with co-morbidities [91,92]. …”
Section: Risks Associated With Persistent and Untreated Endo Subclinimentioning
confidence: 99%