Subclinical Hepatitis in Rubeola Infections in Young Adults

Nickell, Michael D.; Cannady, Preston B.; Schwitzer, Gregory A.

doi:10.7326/0003-4819-90-3-354

Cited by 28 publications

(5 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…He reported a 29-year-old woman with measles who had an elevation ofAST with the development of rash, and also pointed out the manyclinical similarities between measles, infectious mononucleosis and hepatitis A. Since then hepatitis in measles has been often reported in the European and American literature (1)(2)(3)(4). It occurs more frequently in adolescents and young adults (5,7,13).…”

Section: Discussionmentioning

confidence: 99%

“…Hepatitis in measles is reported commonly in the European and American literature (1)(2)(3)(4). Liver dysfunction has occurred frequently in young adults (3)(4)(5)(6)(7). However, such cases in Japan are relatively rare (6,8,9).…”

Section: Introductionmentioning

confidence: 99%

“…Several complications have been described in measles, including respiratory tract infection, pneumonia, otitis media, ileocolitis, myocarditis, encephalitis and subacute sclerosing panencephalitis (SSPE) (1). Hepatitis in measles is reported commonly in the European and American literature (1)(2)(3)(4). Liver dysfunction has occurred frequently in young adults (3)(4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinicopathological Study on Liver Dysfunction in Measles.

et al. 1999

View full text Add to dashboard Cite

Weanalyzed the clinical course of eight patients with liver dysfunction in measles. All of the patients showed an elevation of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH), but no jaundice. These levels returned to normal about 3 weeks after the onset of the rash. A percutaneous liver biopsy was done in two cases. Histological examination showedslight necrosis of liver cells but no significant changes in portal area. On electron microscopy, virus particles were not detected. Wedetected measles virus RNAin the liver specimenby RT-PCR,which suggests that the measles virus affects liver cells directly in measles. (Internal Medicine 38: 454-457, 1999)

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinicopathological Study on Liver Dysfunction in Measles.

et al. 1999

View full text Add to dashboard Cite

show abstract

“…1979, transaminases had normalized. Be cause serology for HbS-AG, hepatitis A, cytomegalovirus and Epstein-Barr virus remained negative, the presence of rubella-hepatitis [18] was suspected. The skin rash disappeared after 2 weeks without leaving residua.…”

Section: Case Reportmentioning

confidence: 99%

Systemic Hypersensitivity to Allopurinol with Acute Interstitial Nephritis

Grussendorf¹,

Andrássy²,

Waldherr³

et al. 1981

Am J Nephrol

View full text Add to dashboard Cite

A patient with a history of iridocyclitis and discrete IgA glomerulonephritis had two severe systemic reactions to allopurinol with fever, macular rash, and prolonged renal insufficiency without hypertension, edema or a nephritic sediment. Upon controlled re-exposure, cutaneous vasculitis and acute interstitial nephritis were observed. Immunohistology only showed granular C3 deposits to the tubular basement membrane. Circulating antibodies to tubular basement membranes were positive. After several months, serum creatinine had almost returned to initial levels.

show abstract

“…T h e first case report of hepatic dysfunction in measles appeared in 1960 (2). Later, it was reported that more than 50% of adults hospitalized for the disease have impaired liver function; still, overt jaundice seemed uncommon (3)(4)(5).…”

mentioning

confidence: 99%

Hepatitis during measles in young adults: Possible role of antipyretic drugs

Ackerman¹,

Flugelman²,

Wax³

et al. 1989

Hepatology

View full text Add to dashboard Cite

Fifty-six per cent of 118 young adults observed during a recent measles epidemic had some disturbance on liver function tests. Five per cent developed overt jaundice. Patients treated for fever with paracetamol were found to have significantly higher rates of transaminase impairment compared to those treated with dipyrone. Sixty-five and 58% of patients given paracetamol had elevated ALT and AST levels, respectively. Only 15% of patients given dipyrone had elevated levels of these two enzymes (p less than 0.01 for ALT and p less than 0.02 for AST). The mean levels of transaminases and bilirubin in the paracetamol-treated patients were significantly higher than those found in the dipyrone-treated patients [92 +/- 86 vs. 42 +/- 49 IU (p less than 0.02) for AST and 12 +/- 6.0 vs. 7.0 +/- 2.0 mumoles per liter (p less than 0.01) for bilirubin]. The cumulative dose of paracetamol in those who had impaired liver function was higher than that ingested by patients who did not develop liver damage, although still within the usual therapeutic range [11.6 +/- 5.8 vs. 7.6 +/- 4.2 gm (p = 0.02)]. The possible ways in which measles infection and paracetamol in combination can lead to hepatic damage are discussed.

show abstract

Subclinical Hepatitis in Rubeola Infections in Young Adults

Cited by 28 publications

References 2 publications

Clinicopathological Study on Liver Dysfunction in Measles.

Clinicopathological Study on Liver Dysfunction in Measles.

Systemic Hypersensitivity to Allopurinol with Acute Interstitial Nephritis

Hepatitis during measles in young adults: Possible role of antipyretic drugs

Contact Info

Product

Resources

About