Subclinical Hearing Loss is Associated With Depressive Symptoms

Golub, Justin S.; Brewster, Katharine K.; Brickman, Adam M.; Ciarleglio, Adam; Kim, Ana H.; Luchsinger, José A.; Rutherford, Bret R.

doi:10.1016/j.jagp.2019.12.008

Cited by 37 publications

(43 citation statements)

References 43 publications

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“…In otorhinolaryngology head and neck surgery (ORL HNS), the association between psychological comorbidities and post-treatment outcome has been minimally investigated. The coexistence of depressive disorders and head and neck cancer [37,38], chronic rhinosinusitis [39,40], allergic disorders [41], tinnitus [42], and hearing disorders [12][13][14] is well described. However, the impact of psychological burden on PROMs after treatment was assessed in only a few studies.…”

Section: Discussionmentioning

confidence: 99%

“…The ZCMEI-21 has been previously validated in German language [9] and included four subscales: "ear signs and symptoms" (items 1-5), "hearing function" (items 6-10), "psychosocial impact" (items [11][12][13][14][15][16][17][18], and the "use of medical resources" (items [19][20][21]. All answers are presented using a 5-point Likert scale.…”

Section: Zcmei-21mentioning

confidence: 99%

“…Depression has long been associated with hearing disorders [12][13][14]. However, the coexistence of mood disorders in patients with COM was analyzed in only a few studies [15,16].…”

Section: Introductionmentioning

confidence: 99%

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Impact of depressive disorders on quality of life after middle ear surgery in patients with chronic otitis media

Lailach

Langanke

Zahnert

et al. 2020

Eur Arch Otorhinolaryngol

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Purpose The aim of this study was to determine whether preoperative depressive symptoms influence health-related quality of life (HRQOL) after middle ear surgery in patients with chronic otitis media (COM). Methods This prospective clinical case study was conducted at a tertiary referral center. All 102 patients who had undergone middle ear surgery for COM were assessed clinically and by audiometric testing (pure tone audiometry) in pre- and postoperative settings. Disease-specific HRQOL was assessed by the validated chronic otitis media outcome test 15 (COMOT-15) and the Zurich chronic middle ear inventory (ZCMEI-21). General HRQOL was measured using the short form 36 (SF-36). Depressive symptoms were assessed using the patient health questionnaire (PHQ-D). The Charlson comorbidity index (CCI) was used to classify comorbidities. The middle ear status was determined using the ossiculoplasty outcome parameter staging (OOPS) index. Results After middle ear surgery, the total COMOT-15 and ZCMEI-21 scores improved significantly (p < 0.001). General HRQOL (total SF-36 score) was unaffected by surgery (p < 0.05). Patients without elevated depressive symptoms had significantly better total scores for the COMOT-15 (p < 0.01), ZCMEI-21 (p < 0.001), and for SF-36 (p < 0.001) postoperatively. The results of the multiple regression analyses show that, after adjusting for the OOPS, CCI, and hearing improvement, preoperative depressiveness was significantly associated with worse postoperative COMOT-15 and ZCMEI-21 outcome scores (β = 0.425 and β = 0.362, p < 0.001). Conclusion Preoperative depressiveness was an essential predictive factor for HRQOL in patients with COM. This should be considered during patient selection to provide more suitable preoperative counseling.

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Section: Discussionmentioning

confidence: 99%

Section: Zcmei-21mentioning

confidence: 99%

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Impact of depressive disorders on quality of life after middle ear surgery in patients with chronic otitis media

Lailach

Langanke

Zahnert

et al. 2020

Eur Arch Otorhinolaryngol

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“…Previous epidemiological studies revealed that the prevalence of sensory and motor dysfunction and cognition deficit, frailty, and tinnitus increases with age ( Shargorodsky et al, 2010 ; Panza et al, 2015 ; Ruan et al, 2018 ; Jafari et al, 2019 ). Although HL is associated with cognitive impairment, frailty, and motor dysfunction ( Chen et al, 2014 ; Panza et al, 2015 ; Kamil et al, 2016 ; Deal et al, 2017 ; Bang et al, 2020 ; Bonfiglio et al, 2020 ), identifying the causal relationship between HL and frailty phenotype and cognition decline is difficult because HL is similar to pre-MCI, with long subclinical period ( Golub et al, 2019 , 2020 ). Our results revealed that aging does not increase the severity of tinnitus and confirmed the reports of previous studies, which indicated that depression increases the risk for severe HL or tinnitus ( Shargorodsky et al, 2010 ; Langguth et al, 2013 ; House et al, 2018 ; Ruan et al, 2018 ; Jafari et al, 2019 ; Golub et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

“…The coexistence of physical frailty and HL in older adults was related to a worse cognitive performance compared with HL alone ( Bonfiglio et al, 2020 ). Furthermore, cognitive impairment and depressive symptoms may be present during subclinical HL ( Golub et al, 2019 , 2020 ). The occurrence of HL on at least one side in older adults can significantly affect the motor functions and increase the risk of postural instability and falls ( Bang et al, 2020 ); it is independently associated with mobility frailty ( Kamil et al, 2016 ), greater disability, and limitations in multiple self-reported difficulties in physical functioning ( Chen et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Heterogeneous Influence of Frailty Phenotypes in Age-Related Hearing Loss and Tinnitus in Chinese Older Adults: An Explorative Study

et al. 2021

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BackgroundFried physical frailty, with mobility frailty and non-motor frailty phenotypes, is a heterogeneous syndrome. The coexistence of the two phenotypes and cognitive impairment is referred to as cognitive frailty (CF). It remains unknown whether frailty phenotype has a different association with hearing loss (HL) and tinnitus.MethodsOf the 5,328 community-dwelling older adults, 429 participants aged ≥58 years were enrolled in the study. The participants were divided into robust, mobility, and non-mobility frailty, mobility and non-mobility CF (subdivided into reversible and potentially reversible CF, RCF, and PRCF), and cognitive decline [subdivided into mild cognitive impairment (MCI) and pre-MCI] groups. The severity and presentations of HL and/or tinnitus were used as dependent variables in the multivariate logistic or nominal regression analyses with forward elimination adjusted for frailty phenotype stratifications and other covariates.ResultsPatients with physical frailty (mobility frailty) or who are robust were found to have lower probability of developing severe HL and tinnitus, and presented HL and/or tinnitus than those with only cognitive decline, or CF. Patients with RCF and non-mobility RCF had higher probability with less HL and tinnitus, and the presentation of HL and/or tinnitus than those with PRCF and mobility RCF. Other confounders, age, cognitive and social function, cardiovascular disease, depression, and body mass index, independently mediated the severity of HL and tinnitus, and presented HL and/or tinnitus.ConclusionFrailty phenotypes have divergent association with HL and tinnitus. Further research is required to understand the differential mechanisms and the personalized intervention of HL and tinnitus.Clinical Trial RegistrationClinicalTrials.gov identifier, NCT2017K020.

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Association of Hearing Impairment and 24-Hour Total Movement Activity in a Representative Sample of US Adults

et al. 2022

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IMPORTANCE Lower physical activity (PA) levels have been proposed as a mechanism to explain the association between hearing loss and various adverse outcomes of aging. But whether hearing loss is associated with lower PA is poorly understood. OBJECTIVE To evaluate whether hearing loss is associated with lower levels of PA. DESIGN, SETTING, AND PARTICIPANTSThis cross-sectional analysis was conducted in a representative sample of US adults (aged 30-69 years) who participated in the 2011-2012 cycle of the National Health and Nutrition Examination Survey (NHANES). Data analysis was conducted from July to September 2021.EXPOSURES Hearing was assessed, in dB, by pure-tone audiometry and summarized as the better hearing ear's pure-tone average (BPTA) of 4 speech frequencies (500, 1000, 2000, and 4000 kHz); a higher BTPA indicates worse hearing. Hearing was also categorized into normal (BPTA Յ25 dB), mild hearing impairment (>25 to 40 dB), and moderate or greater hearing impairment (>40 dB). MAIN OUTCOMES AND MEASURESTotal 24-hour movement activity was measured using wrist accelerometers worn at all times for 7 consecutive days and summarized in monitor-independent movement summary units (MIMS) units (higher MIMS units indicate more movement). The association between BPTA and MIMS units was evaluated using a multivariable-adjusted (demographic characteristics and chronic conditions) piecewise spline regression (knot at 15 dB).Mean differences in MIMS units across hearing categories compared with normal hearing were estimated. RESULTSThe study included 2490 participants (mean [SE] age, 48.9 [0.3] years; 900 [weighted percentage, 69.3%] White individuals, 1248 [weighted percentage, 50.8%] female participants).Before the knot at 15 dB, we found that each 10-dB higher BPTA was associated with 860.4 (95% CI, 444.8-1276.1) higher MIMS units. Conversely, after the knot, each 10-dB higher BPTA was associated with 458.6 (95% CI, 27.7-889.4) lower MIMS units. The difference in MIMS units across hearing categories was not statistically significant. CONCLUSIONS AND RELEVANCEIn this cross-sectional study, in the range of hearing sensitivity of BPTA of 15 dB or greater, worse hearing was associated with lower MIMS units. Lower PA may be a mechanism contributing to the association between hearing impairment and adverse health.

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Subclinical Hearing Loss is Associated With Depressive Symptoms

Cited by 37 publications

References 43 publications

Impact of depressive disorders on quality of life after middle ear surgery in patients with chronic otitis media

Impact of depressive disorders on quality of life after middle ear surgery in patients with chronic otitis media

Heterogeneous Influence of Frailty Phenotypes in Age-Related Hearing Loss and Tinnitus in Chinese Older Adults: An Explorative Study

Association of Hearing Impairment and 24-Hour Total Movement Activity in a Representative Sample of US Adults

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