Subclinical First Trimester Renal Abnormalities Are Associated With Preeclampsia in Normoalbuminuric Women With Type 1 Diabetes

Kelly, Clare B.; Hookham, Michelle B.; Yu, Yongxin; Jenkins, Alicia J.; Nankervis, Alison; Hanssen, Kristian F.; Garg, Satish K.; Scardo, James A.; Hammad, Samar M.; Menard, M. Kathryn; Aston, Christopher E.; Lyons, Timothy J.

doi:10.2337/dc17-1635

Cited by 16 publications

(25 citation statements)

References 45 publications

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“…The higher serum creatinine in GDM with later PE seems in line with the hypothesis of subtle renal abnormalities predisposing to PE in GDM, as proposed by Kelly et al (1) in T1DM, but it contrasts with the hyperfiltration that they reported. The estimation of GFR should be done cautiously in pregnant women, but our results suggest that serum creatinine may be a parameter of clinical interest in pregnant women with diabetes prone to PE.…”

supporting

confidence: 84%

“…We were interested by the article from Kelly et al (1), who reported that markers of subclinical renal damage predicted later preeclampsia (PE) in pregnant women with type 1 diabetes mellitus (T1DM). Although the best predictor was neutrophil gelatinase-associated lipocalin, our interest focused on the higher estimated glomerular filtration rates (determined by the Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] equation) before preeclampsia.…”

mentioning

confidence: 99%

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Comment on Kelly et al. Subclinical First Trimester Renal Abnormalities Are Associated With Preeclampsia in Normoalbuminuric Women With Type 1 Diabetes. Diabetes Care 2018;41:120–127

et al. 2018

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confidence: 84%

mentioning

confidence: 99%

Comment on Kelly et al. Subclinical First Trimester Renal Abnormalities Are Associated With Preeclampsia in Normoalbuminuric Women With Type 1 Diabetes. Diabetes Care 2018;41:120–127

et al. 2018

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“…Hence, the search for a more realistic and reliable diagnostic marker cannot be overemphasized as a therapeutic target for the treatment of hypertension and its complications. The kidney injury molecule‐1 (Kim‐1) has be found to be one of the recent markers of renal injury especially to the early tubular and glomerular dysfunction . Administration of NaF upregulated the expressions of Kim‐1 as indicative of acute renal damage while co‐treatment of NaF and Luteolin lowered Kim‐1 expressions asserting the nephroprotective effect of Luteolin as earlier described .…”

Section: Discussionmentioning

confidence: 67%

Luteolin‐mediated Kim‐1/NF‐kB/Nrf2 signaling pathways protects sodium fluoride‐induced hypertension and cardiovascular complications

et al. 2018

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The use of sodium fluoride (NaF) as a major ingredient for tooth paste, mouth wash, and mouth rinse has become inevitable in our day-to-day life. However, flavonoids such as Luteolin might be of great value in the prevention of toxicity associated with accidental or inevitable ingestion of NaF. In the study, 40 male Wistar albino rats were randomly divided into four groups with 10 rats in a group. Group A was the control group and received normal saline, Group B was exposed to NaF at 300 ppm (300 mg/L) in drinking water daily for a week, Groups C and D were exposed to 300 ppm (300 mg/L) of NaF and coadministered with Luteolin orally daily at a dosage of 100 mg/kg and 200 mg/kg for the same time point. Our results indicated that NaF caused significant increases in systolic blood pressure, diastolic blood pressure, mean arterial pressure, malondialdehyde, protein carbonyl, myeloperoxidase, advanced oxidative protein products, together with significant reductions in glutathione peroxidase, superoxide dismutase, catalase, glutathione reductase, reduced glutathione, and nitric oxide (NO) bioavailability. The electrocardiogram results showed that NaF alone caused significant prolongation of QT and QTc intervals. Immunohistochemistry revealed that NaF caused increase expressions of Kidney injury marker 1 (Kim-1), nuclear factor 518 BioFactors Research Communication kappa bet (NF-κB), nuclear factor erythroid 2-related factors 2 (Nrf2), and cardiac troponin I (CTnI). Together, Luteolin coadministration with NaF improved NO bioavailability, reduced high blood pressure, markers of oxidative stress, reversed prolongation of QT and QTc intervals, and lowered the expressions of Kim-1, NF-κB, and CTnI. © 2018 BioFactors, 44(6):518-531, 2018

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“…Women were excluded from our study if they had microalbuminuria or more severe albuminuria at V1. Nevertheless, other evidence from the MAMPED cohort supports the concept that subtle, early renal abnormalities confer PE risk: specifically, increased first trimester urinary neutrophil-gelatinase associated lipocalin (creatinine corrected) (uNGALcc) and elevated estimated glomerular filtration rates (eGFR) [35]. Relating the current data to these prior findings, we observed-specifically in DM+PE+ women at the first trimester-that total, bioavailable, and free 25(OH)D were negatively correlated with eGFR (all p < 0.05), while total and free 1,25(OH) 2 D at V2 were positively correlated with uNGALcc (p < 0.05).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Metabolites and Binding Protein Predict Preeclampsia in Women with Type 1 Diabetes

et al. 2020

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The risk for preeclampsia (PE) is enhanced ~4-fold by the presence of maternal type 1 diabetes (T1DM). Vitamin D is essential for healthy pregnancy. We assessed the total, bioavailable, and free concentrations of plasma 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)2D), and vitamin D binding protein (VDBP) at ~12, ~22, and ~32 weeks’ gestation (“Visits” (V) 1, 2, and 3, respectively) in 23 T1DM women who developed PE, 24 who remained normotensive, and 19 non-diabetic, normotensive women (reference controls). 25(OH)D deficiency was more frequent in diabetic than non-diabetic women (69% vs. 22%, p < 0.05), but no measure of 25(OH)D predicted PE. By contrast, higher 1,25(OH)2D concentrations at V2 (total, bioavailable, and free: p < 0.01) and V3 (bioavailable: p < 0.05; free: p < 0.01), lower concentrations of VDBP at V3 (p < 0.05), and elevated ratios of 1,25(OH)2D/VDBP (V2, V3: p < 0.01) and 1,25(OH)2D/25(OH)D (V3, p < 0.05) were all associated with PE, and significance persisted in multivariate analyses. In summary, in women with T1DM, concentrations of 1,25(OH)2D were higher, and VDBP lower, in the second and third trimesters in women who later developed PE than in those who did not. 1,25(OH)2D may serve as a new marker for PE risk and could be implicated in pathogenesis.

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Subclinical First Trimester Renal Abnormalities Are Associated With Preeclampsia in Normoalbuminuric Women With Type 1 Diabetes

Abstract: Early tubular and glomerular dysfunction may predict PE in first trimester women with T1DM, even if free of microalbuminuria. These data suggest that subclinical renal tubular and glomerular injury, if present early in pregnancy, may predispose women with T1DM to PE.

Cited by 16 publications

References 45 publications

Comment on Kelly et al. Subclinical First Trimester Renal Abnormalities Are Associated With Preeclampsia in Normoalbuminuric Women With Type 1 Diabetes. Diabetes Care 2018;41:120–127

Comment on Kelly et al. Subclinical First Trimester Renal Abnormalities Are Associated With Preeclampsia in Normoalbuminuric Women With Type 1 Diabetes. Diabetes Care 2018;41:120–127

Luteolin‐mediated Kim‐1/NF‐kB/Nrf2 signaling pathways protects sodium fluoride‐induced hypertension and cardiovascular complications

Vitamin D Metabolites and Binding Protein Predict Preeclampsia in Women with Type 1 Diabetes

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