Subclinical enthesitis in nail psoriasis patients: a case‐control study

Klaassen, Karlijn M.G.; Ploegmakers, Marieke J.M.; Kerkhof, P.C.M. van de; Klein, Willemijn M.; Pasch, Marcel C.

doi:10.1111/ddg.13222

Cited by 12 publications

(11 citation statements)

References 39 publications

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“…[12][13][14][15][16][17] These findings are supported by the growing evidence for an anatomical correlation between nail psoriasis and enthesitis of the DIP joints, as a manifestation of PsA. 18,19 Besides a higher psoriasis severity, 4 a longer duration of psoriatic skin lesions is also associated with a higher frequency in nail changes. 20 The relatively long duration of disease could partly account for the high prevalence of nail changes in our population.…”

Section: Discussionmentioning

confidence: 81%

<p>The Skin May Clear But the Arthritis Won’t Disappear: Focusing on Concomitant and New-Onset Psoriatic Arthritis in a Daily Practice Cohort of Psoriasis Patients on Biologic Therapy</p>

Muijen

Hal

Groenewoud

et al. 2020

PTT

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Background Previously identified risk factors for psoriatic arthritis (PsA); nail dystrophy and scalp lesions are highly prevalent in patients with moderate-to-severe psoriasis. Therefore, these variables may not be useful as predictors for PsA in this population. Objective We assessed the predictive value of demographic and clinical characteristics for development of PsA in a cohort of patients with moderate-to-severe psoriasis, currently treated with biologics. Furthermore, we reported the incidence of new-onset PsA in this population and described the characteristics of patients that developed PsA during biologic treatment. Methods Demographics and treatment characteristics of psoriasis patients currently using biologic therapy were extracted from the BioCAPTURE database (n=427). Poisson regression was used to calculate incidence rates. Multivariable logistic regression was performed to identify factors independently associated with PsA onset. Patient and treatment characteristics of patients that developed PsA during biologic treatment were described. Results The incidence of PsA was 1.0 (95% CI 0.8–1.2) per 100 psoriasis-years. Except for a lower risk for PsA in male gender (OR 0.58, 95% CI 0.34–0.98, p-value 0.04), no clinical factors were significantly associated with an altered risk of developing PsA. During biologic therapy, 32 patients (9.4%) newly developed PsA. In this group, 53.8% had PASI<5 at PsA diagnosis. The incidence rate of PsA was 1.6 (95% CI 1.1–2.2) per 100 years on biologic therapy. Conclusion Clinical risk factors might be inaccurate to predict PsA onset in patients with moderate-to-severe psoriasis on biologics. Even with low disease activity, psoriasis patients on biologics are still prone to develop PsA.

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Section: Discussionmentioning

confidence: 81%

<p>The Skin May Clear But the Arthritis Won’t Disappear: Focusing on Concomitant and New-Onset Psoriatic Arthritis in a Daily Practice Cohort of Psoriasis Patients on Biologic Therapy</p>

Muijen

Hal

Groenewoud

et al. 2020

PTT

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“…Otro signo frecuente de la APs es la psoriasis ungueal 42 . Algunos autores consideran que los pacientes con psoriasis ungueal tienen mayor probabilidad de padecer entesitis y afectación interfalángica distal 43 , 44 . Por consiguiente, los dermatólogos deben familiarizarse con estos signos, ya que pueden ser la única manifestación de la APs en los pacientes durante la fase precoz de la enfermedad.…”

Section: Resultsunclassified

El papel del dermatólogo en el diagnóstico precoz de la artritis psoriásica: recomendaciones de un grupo de expertos

Belinchón

Salgado‐Boquete

López‐Ferrer

et al. 2020

Actas Dermo-Sifiliográficas

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Resumen La artritis psoriásica (APs) es una forma común de artritis inflamatoria que aparece hasta en el 40% de los pacientes con psoriasis. Dado que la afectación cutánea suele preceder a la afectación articular, los dermatólogos desempeñan un papel fundamental en la detección precoz de la APs. El diagnóstico precoz es importante para reducir el riesgo de daños estructurales irreversibles, limitar el deterioro de la función física y mejorar la calidad de vida de los pacientes. El presente documento ha sido elaborado por un grupo de especialistas (nueve dermatólogos y un reumatólogo) con el objetivo de proporcionar recomendaciones sencillas que ayuden a los dermatólogos en el cribado de la APs en pacientes con psoriasis. Los expertos elaboraron el presente documento ofreciendo unas recomendaciones consensuadas basadas en una revisión descriptiva de la evidencia científica disponible y en la experiencia adquirida en la práctica clínica diaria.

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“…It affects 2-3% of the population and is characterized by scaly and erythematous skin patches, papules, and plaques (5,6). Psoriasis does not only affect the skin, but also known to have a systemic component as it was reported to affect various organs (7), leading to joint disorders (8), enthesitis (9,10), cardiovascular events (11), arterial hypertension (12), diabetes (13), and non-alcoholic fatty liver (14). It remains controversial whether psoriasis can be considered as an independent risk factor for these diseases (15,16).…”

Section: Introductionmentioning

confidence: 99%

“…It remains controversial whether psoriasis can be considered as an independent risk factor for these diseases (15,16). Patients with psoriasis are routinely screened for prevalent well-known comorbidities, including cardiovascular diseases and diabetes mellitus (7)(8)(9)(10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Subclinical High Resolution Chest CT Scan Features In Psoriasis

Samrah

Qarqaz

Obeidat

et al. 2022

Preprint

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Background: Although psoriasis is considered a systemic disease, no clear association has been established between psoriasis and lung diseases. Methods: Adult psoriasis patients with no known active pulmonary disease or respiratory symptoms were screened for subclinical pulmonary manifestations and possible parenchymal changes using high-resolution computed tomography (HRCT) scan of the chest. Patients were classified according to the severity of skin manifestations. The clinical characteristics and radiographic findings of these patients were evaluated.Results: A total of 59 patients with psoriasis were included, among which 47 (79.7%) had abnormal HRCT scan features. Micronodules were the most common detected lung lesions (66.1%), followed by interlobular septal thickening (23.7%), fibrosis (11.9%), and ground-glass opacity (6.8%). Other HRCT findings included emphysematous changes and calcified granulomas. Abnormal HRCT findings correlated with older age and duration of psoriasis but not with the severity of skin manifestations.Conclusions: Micronodules and interlobular septal thickening were the most detected lung lesions in patients with psoriasis. These findings of the pilot study highlight the possible pulmonary involvement in patients with psoriasis. Larger multicenter studies are needed to further clarify these findings.

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Subclinical enthesitis in nail psoriasis patients: a case‐control study

Abstract: The present study provides evidence for subclinical enthesitis at the level of the DIP joint in patients with nail psoriasis. However, an anatomical correlation between nail psoriasis and psoriatic arthritis could not be confirmed.

Cited by 12 publications

References 39 publications

<p>The Skin May Clear But the Arthritis Won’t Disappear: Focusing on Concomitant and New-Onset Psoriatic Arthritis in a Daily Practice Cohort of Psoriasis Patients on Biologic Therapy</p>

<p>The Skin May Clear But the Arthritis Won’t Disappear: Focusing on Concomitant and New-Onset Psoriatic Arthritis in a Daily Practice Cohort of Psoriasis Patients on Biologic Therapy</p>

El papel del dermatólogo en el diagnóstico precoz de la artritis psoriásica: recomendaciones de un grupo de expertos

Subclinical High Resolution Chest CT Scan Features In Psoriasis

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