Subclinical encephalopathy in chronic obstructive pulmonary disease

Lima, Olga Maria Pinto de; Oliveira‐Souza, Ricardo de; Santos, Omar da Rosa; Moraes, Pedro Araújo de; Sá, Leonardo Fontenelle de; Nascimento, Osvaldo J. M.

doi:10.1590/s0004-282x2007000700012

Cited by 9 publications

(7 citation statements)

References 24 publications

(15 reference statements)

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“…In fact, a relationship has been found between the Mini-Mental State Examination score and the severity of COPD (r = −0.49, p < 0.001). ( 28 ) However, the study conducted by Salik et al ( 29 ) showed that cognitive function in COPD patients with mild hypoxemia was similar to that observed for healthy subjects. According to those authors, cognitive function is affected by hypoxemia only when the latter is severe.…”

Section: Discussionmentioning

confidence: 73%

“…Various controlled studies have investigated the prevalence of cognitive impairment in COPD, ( 21 , 25 , 28 ) showing that prevalence to be higher in COPD patients than in healthy control subjects. ( 10 , 31 ) According to such studies, mild cognitive impairment is present in 36% of COPD patients and in 12% of subjects without COPD.…”

Section: Discussionmentioning

confidence: 99%

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Cognitive impairment in COPD: a systematic review

et al. 2015

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The objectives of this study were to characterize and clarify the relationships between the various cognitive domains affected in COPD patients and the disease itself, as well as to determine the prevalence of impairment in the various cognitive domains in such patients. To that end, we performed a systematic review using the following databases: PubMed, Scopus, and ScienceDirect. We included articles that provided information on cognitive impairment in COPD patients. The review of the findings of the articles showed a significant relationship between COPD and cognitive impairment. The most widely studied cognitive domains are memory and attention. Verbal memory and learning constitute the second most commonly impaired cognitive domain in patients with COPD. The prevalence of impairment in visuospatial memory and intermediate visual memory is 26.9% and 19.2%, respectively. We found that cognitive impairment is associated with the profile of COPD severity and its comorbidities. The articles reviewed demonstrated that there is considerable impairment of the cognitive domains memory and attention in patients with COPD. Future studies should address impairments in different cognitive domains according to the disease stage in patients with COPD.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Cognitive impairment in COPD: a systematic review

et al. 2015

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“… 65 , 66 dysexecutive syndrome 65 , 66 . 69 , 75 and difficulties in abstract thinking 53 were found, while visual attention can be relatively preserved. Other authors argue that there is also visual attention impairment.…”

Section: Cognitive Impairment In Pulmonary Diseases With Chronic Hypomentioning

confidence: 93%

Cognition and chronic hypoxia in pulmonary diseases

Areza-Fegyveres

Kairalla

Carvalho

et al. 2010

Dement. neuropsychol.

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Lung disease with chronic hypoxia has been associated with cognitive impairment of the subcortical type.ObjectivesTo review the cognitive effects of chronic hypoxia in patients with lung disease and its pathophysiology in brain metabolism.MethodsA literature search of Pubmed data was performed. The words and expressions from the text subitems including “pathophysiology of brain hypoxia”, “neuropsychology and hypoxia”, “white matter injury and chronic hypoxia”, for instance, were key words in a search of reports spanning from 1957 to 2009. Original articles were included.ResultsAccording to national and international literature, patients with chronic obstructive pulmonary disease and sleep obstructive apnea syndrome perform worse on tests of attention, executive functions and mental speed. The severity of pulmonary disease correlates with degree of cognitive impairment. These findings support the diagnosis of subcortical type encephalopathy.ConclusionCognitive effects of clinical diseases are given limited importance in congresses and symposia about cognitive impairment and its etiology. Professionals that deal with patients presenting cognitive loss should be aware of the etiologies outlined above as a major cause or potential contributory factors, and of their implications for treatment adherence and quality of life.

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“…The central nervous system, in particular, is vulnerable to hypoxemic insults and systemic inflammatory stress. Some studies have shown that COPD patients exhibit earlier cognitive decline in age and health status than expected [5,6]. However, the mechanisms involved in the impairment of cognition and the relevant factors are complex and not fully understood [7,8].…”

Section: Introductionmentioning

confidence: 99%

The Evaluation of Cognitive Impairment and Relevant Factors in Patients with Chronic Obstructive Pulmonary Disease

Huang

Zhang³

2012

Respiration

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Background: Chronic obstructive pulmonary disease (COPD) is understood to be a complex multicomponent disorder. The impairment of cognition is lasting and profound. However, the pattern of the cognitive decline and potentially adverse factors are poorly understood. Objectives: To evaluate the cognitive performances and the relevant factors in COPD patients and to investigate the relationship between cognition deficits and the classification of severity of the disease. Methods: Twenty-seven mild-to-moderate COPD patients, 35 severe COPD patients and 27 control subjects were recruited. Cognitive states were investigated by the Mini-Mental State Examination (MMSE). Pulmonary function, arterial blood gas and serum clusterin level were evaluated in each subject. Results: Lower MMSE score and higher serum clusterin concentration were observed in mild-to-moderate COPD patients, while the lowest MMSE score and the highest serum clusterin level were found in severe COPD patients when compared with control subjects. MMSE score is positively correlated with arterial oxygen tension and is inversely associated with serum clusterin level in both mild-to-moderate and severe COPD patients. Furthermore, MMSE scores and serum clusterin concentrations were correlated with forced expiratory volume in 1 s in severe COPD patients. Conclusion: Cognitive impairment was found in COPD patients. It is associated with the classification of disease severity, hypoxemia and serum clusterin level. An increased serum clusterin level may be a relevant peripheral biomarker of cognitive dysfunction in COPD patients.

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Subclinical encephalopathy in chronic obstructive pulmonary disease

Cited by 9 publications

References 24 publications

Cognitive impairment in COPD: a systematic review

Cognitive impairment in COPD: a systematic review

Cognition and chronic hypoxia in pulmonary diseases

The Evaluation of Cognitive Impairment and Relevant Factors in Patients with Chronic Obstructive Pulmonary Disease

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