Subclinical cushing syndrome due to adrenocorticotropic hormone-independent macronodular adrenocortical hyperplasia: changes in plasma cortisol levels during long-term follow-up

Sasao, Takumi; Itoh, Naoki; Sato, Yoshikazu; Takahashi, Atsushi; Tsukamoto, Taiji

doi:10.1016/s0090-4295(99)00381-7

Cited by 13 publications

(7 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Despite this, the optimal treatment of SCS due to AIMAH has not been established. Recently, with the wider use of imaging techniques, several cases of SCS due to AIMAH have been reported . In patients with SCS caused by AIMAH, adrenal nodules were found incidentally, and their autonomous cortisol secretion was not sufficiently abnormal to cause overt CS.…”

Section: Discussionmentioning

confidence: 99%

“…Traditionally, bilateral adrenalectomy by either an overt or laparoscopic approach has been the most useful treatment for patients with AIMAH, although patients are obliged to receive lifetime steroid replacement after the procedure, and subsequently, are susceptible to adrenal insufficiency crisis . In patients with SCS caused by AIMAH, adrenal nodules are generally found incidentally, and their autonomous cortisol secretion is not sufficiently abnormal to cause overt Cushing's syndrome (CS) . Because the amount of cortisol produced by these nodules is not that excessive, we believe that a unilateral adrenalectomy might be sufficient to achieve a reduction in the secretory tissue, especially for SCS due to AIMAH.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Results of unilateral adrenalectomy in subclinical Cushing's syndrome due to adrenocorticotropic hormone‐independent macronodular adrenal hyperplasia

et al. 2012

View full text Add to dashboard Cite

Adrenocorticotropic hormone (ACTH)‐independent bilateral adrenocortical macronodular adrenocortical hyperplasia (AIMAH) is a rare cause of Cushing's syndrome (CS). Traditionally, bilateral adrenalectomy with subsequent lifetime steroid replacement has been considered to be the treatment of choice. In the present study, we evaluated the long‐term results of unilateral adrenalectomy in subclinical CS (SCS) due to AIMAH, with regard to the main laboratory and clinical abnormalities. Two patients with confirmed SCS due to AIMAH underwent unilateral laparoscopic adrenalectomy to reduce the cortisol‐secreting tissue. These procedures were successfully conducted in both cases without open conversion, and no surgery‐related morbidity occurred. In both cases, the size of the remaining adrenal gland appeared quite stable, and neither of the patients showed a Cushingoid appearance. Unilateral adrenalectomy achieved satisfactory and prolonged control of cortisol secretion, and also reduced the risk of metabolic disorders and cardiovascular disease after surgery. It can be a safe and effective treatment for SCS due to AIMAH, while maintaining the patient's quality of life.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Results of unilateral adrenalectomy in subclinical Cushing's syndrome due to adrenocorticotropic hormone‐independent macronodular adrenal hyperplasia

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Sasao and colleagues and Lee and colleagues respectively reported one subclinical AIMAH patient who initially received symptomatic treatment for 7 years and 2 years, respectively. 5,6 When the disease progressed su et al…”

Section: Subclinical Aimahmentioning

confidence: 99%

Classification, diagnosis and treatment of ACTH-independent macronodular adrenal hyperplasia

Dai

Huang

et al. 2013

CUAJ

View full text Add to dashboard Cite

case series E594Cite as: Can Urol Assoc J 2013;7(9-10):e594-7. http://dx.doi.org/10.5489/cuaj.420 Published online September 10, 2013. AbstractACTH-independent macronodular adrenal hyperplasia (AIMAH) is a distinctive subtype of Cushing's syndrome (CS), with different clinical manifestations according to the level of serum cortisol. Based on clinical manifestations and serum cortisol, we divide AIMAH into three types, subclinical AIMAH, clinical AIMAH and high-risk AIMAH, with varied treatment methods being adapted to different subtypes. At the same time, we describe 3 patients who represent these subtypes of this disease, and review some cases of AIMAH which have been previously reported in the English literature. To our knowledge, this is the first article discussing classification, diagnosis and treatment of this disease and should be useful for future therapy of AIMAH.

show abstract

“…Das Hauptcharakteristikum der einer sehr langsamen Progression unterliegenden AIMAH besteht darin, dass sowohl die hormonelle Sekretion als auch Proliferation des Gewebes ACTH-unabhängig sind [7,46]. Typisch ist demnach die fehlende S-Cortisol-Suppression im 2-mg-Dexamethason-Hemmtest, meist kombiniert mit einem erhöh-ten dU-Cortisol.…”

Section: Diskussionunclassified

“…Bei GH sezernierenden Tabelle 4. Charakteristika der ACTH-unabhängigen bilateralen makronodulären Nebennierenrindenhyperplasie (AIMAH) und der bilateralen mikronodulären Nebennierenrindendysplasie (PPNAD) [3,15,18,33,34,46,52,55]. Jedes Cushing-Syndrom bedarf grundsätzlich einer Therapie.…”

Section: Diskussionunclassified

Katecholaminabhängiges hereditäres Cushing-Syndrom - Verlaufsbeobachtung nach einseitiger Adrenalektomie

Imöhl

Köditz

Stachon

et al. 2002

Medizinische Klinik

View full text Add to dashboard Cite

show abstract

Subclinical cushing syndrome due to adrenocorticotropic hormone-independent macronodular adrenocortical hyperplasia: changes in plasma cortisol levels during long-term follow-up

Cited by 13 publications

References 7 publications

Results of unilateral adrenalectomy in subclinical Cushing's syndrome due to adrenocorticotropic hormone‐independent macronodular adrenal hyperplasia

Results of unilateral adrenalectomy in subclinical Cushing's syndrome due to adrenocorticotropic hormone‐independent macronodular adrenal hyperplasia

Classification, diagnosis and treatment of ACTH-independent macronodular adrenal hyperplasia

Katecholaminabhängiges hereditäres Cushing-Syndrom - Verlaufsbeobachtung nach einseitiger Adrenalektomie

Contact Info

Product

Resources

About