Subclinical cochlear dysfunction in newly diagnosed relapsing-remitting multiple sclerosis

Mauro, Roberta Di; Girolamo, Stefano Di; Ralli, Massimo; Vincentiis, Marco de; Mercuri, Nicola Biagio; Albanese, Maria

doi:10.1016/j.msard.2019.05.020

Cited by 14 publications

(30 citation statements)

References 44 publications

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“…As previously demonstrated for other neurological diseases [ 27 , 33 ], our results confirm a potential cochlear impairment in migraineurs, occurring at synaptic level between MOC and OHCs and targeting CGRP activity. A subclinical cochlear discomfort and a concomitant detectable dysfunction of the OHCs by OAEs may represent the earliest sign of sensorineural damage in these patients, providing a powerful tool for the initial diagnosis and an opportunity to monitor disease course and treatment response over time.…”

Section: Discussionsupporting

confidence: 90%

“…Nevertheless, our patients with migraine exhibited deficit in DPOAE suppression compared to healthy subjects, which points to migraine as a disorder affecting in general the peripheral structures and the medial OC efferent system’s integrity. Previous studies already analyzed the OAE suppression in migraineurs, but not using DPOAE-notable more sensitive to detect alteration especially in neuroinflammatory diseases [ 27 ]; moreover the previous studies have been conducted on small-sized sample. Although the total suppression amplitude was lower in the individuals with migraine, these alterations were significantly observed only in a subset of migraineurs, such as women with phonophobia at the selected frequencies of 1–1.5 kHz [ 7 ] or patients with vestibular migraine [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…The first is the sample dimension; we analyzed only 50 patients in the study group and other authors presented results on wide sample; however, we selected a population with episodic headache who were not under pharmacologic prophylactic treatment. As additional, the other authors reported information about TEOAE, while we described DPOAE and their suppression; it is well known the more relevant clinical meaning of DPOAE compared to TEOAE specially to diagnose subclinical pathology [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

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Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study

Albanese

Girolamo

Silvani

et al. 2021

JCM

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Although several cochleo-vestibular symptoms are commonly associated with migraine, only a limited number of studies have been done in this regard. Some reported abnormalities in audiometry, auditory brainstem response and vestibular tests, considering these manifestations mainly related to central etiology. However, increasing evidence also suggests a peripheral involvement of the inner ear in migraine. The aim of this study was to investigate the peripheral auditory pathway in migraineurs using otoacoustic emissions (OAEs), to detect alteration of cochlear functioning and possible relationship with disease severity. Sixty-two migraineurs and sixty matched controls were enrolled in the study and underwent a routine neuro-otolaryngology examination; self-administered questionnaires were used to evaluate subjective perception of hearing disability. DPOAE and their suppression were lower in migraineurs compared to controls and significantly related to the disease duration. Altered DPOAE exposed migraineurs to the risk of affecting by migraine without aura, of presenting with ocular and/or auditory symptoms during attack and of using more painkillers. Concomitant dopaminergic symptoms and/or allodynia such as the acute non-consumption of triptans were significant determinants of decreased contralateral suppression of DPOAE among migraineurs. This potential subclinical cochlear impairment in migraine detected by OAEs may represent the earliest sign of sensorineural damage in these patients, providing a promising tool for the initial diagnosis and an opportunity to monitor disease course and treatment response over time.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study

Albanese

Girolamo

Silvani

et al. 2021

JCM

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“…Sin embargo, el PEATC mostró la afectación subclínica de la vía auditiva conjuntamente con las emisiones otoacústicas. 25 Los PEM como batería de estudio han sido usados para pronosticar el curso de la EM y evaluar los efectos de diferentes tratamientos en la misma. 26,27 En el presente estudio se constató una correlación positiva entre la escala de discapacidad de la enfermedad y el puntaje global de los PEM sensoriales, lo que coincidió con lo reportado por otros autores durante estudios de seguimiento.…”

Section: Discusión De Los Resultadosunclassified

Puntaje Global de Potenciales Evocados Multimodales Sensoriales en el Estudio de Pacientes Con Esclerosis Múltiple.

et al. 2020

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Introducción: La Esclerosis Múltiple (EM) es una enfermedad desmielinizante, inflamatoria y neurodegenerativa del sistema nervioso central, en la que se han utilizado los Potenciales Evocados Multimodales Sensoriales (PEMS) para evaluar la integridad de las vías sensoriales, pero no se han considerado sus resultados para el diagnóstico de la enfermedad. Objetivo: evaluar la relación del puntaje global de PEMS con la magnitud de la discapacidad y la presencia de lesiones en las imágenes de resonancia magnética de pacientes con EM. Métodos: se estudiaron 35 pacientes con EM forma clínica recaídaremisión en el Centro Internacional de Restauración Neurológica. Se correlacionó el puntaje global de los PEMS con la escala de discapacidad de Kurtzke y con las lesiones encontradas en la s imágenes de resonancia magnética. Resultados: se observó una correlación significativa entre el puntaje global y la escala de discapacidad (R=0.33, p< 0.05), y entre este puntaje global y el número de niveles de lesiones detectadas en las imágenes de resonancia (R= 0.42, p< 0.05). Conclusiones: La relación del puntaje global de los PEMS con las lesiones estructurales y el grado de discapacidad confirma su utilidad para el estudio de los pacientes con EM, aun cuando no forman parte de los criterios diagnósticos.

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“…14 47 However, the third study found weaker responses in both TEOAEs and DPOAEs in PwMS compared with healthy controls. 21 Five studies performed PTA on PwMS to assess hearing levels. A total of 510 participants (265 PwMS and 245 healthy controls) were evaluated with PTA, sample size varied from 80 to 146 and age range was between 18 and 65 years.…”

Section: Ms and Auditory Functionmentioning

confidence: 99%

Effects of multiple sclerosis on the audio-vestibular system: a systematic review

2022

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ObjectiveSystematically investigate the effects of multiple sclerosis (MS) on the audio-vestibular system.MethodsSystematic review of literature investigating audio-vestibular conditions in persons with MS (PwMS) aged ≥18 years. PubMed, Scopus, NICE and Web of Science were searched. Randomised controlled trials, and cohort, case–control, observational and retrospective studies in English, published from 2000 to 21 November 2021, evaluated PwMS with at least one outcome (pure tone audiometry, auditory brainstem response, otoacoustic emissions, cortical auditory evoked potentials, functional MRI assessing auditory function, vestibular evoked myogenic potentials, videonystagmography, electronystagmography, posturography, rotary chair, gaps in noise, word discrimination scores, duration pattern sequence test), were included. Study selection and assessments of bias were independently conducted by two reviewers using the Risk of Bias Assessment Tool for Non-randomized Studies, Newcastle-Ottawa Scale (NOS) and the NOS adapted for cross-sectional studies.Results35 studies were included. Auditory function was evaluated in 714 PwMS and 501 controls, vestibular function was evaluated in 682 PwMS and 446 controls. Peripheral auditory function results were contradictory between studies; some found abnormalities in PwMS, and others found no differences. Tests of brainstem and central auditory functions were more consistently found to be abnormal in PwMS. Most vestibular tests were reported as abnormal in PwMS, abnormalities were either peripheral or central or both. However, quantitative analyses could not be performed due to discrepancies between studies in results reporting, test stimulus and recording parameters.ConclusionsAlthough abnormal results on auditory and vestibular tests were noted in PwMS, specific effects of MS on the audio-vestibular system could not be determined due to the heterogeneity between studies that restricted the ability to conduct any quantitative analyses. Further research with consistent reporting, consistent stimulus and consistent recording parameters is needed in order to quantify the effects of MS on the auditory and vestibular systems.PROSPERO registration numberCRD42020180094.

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Subclinical cochlear dysfunction in newly diagnosed relapsing-remitting multiple sclerosis

Cited by 14 publications

References 44 publications

Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study

Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study

Puntaje Global de Potenciales Evocados Multimodales Sensoriales en el Estudio de Pacientes Con Esclerosis Múltiple.

Effects of multiple sclerosis on the audio-vestibular system: a systematic review

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