Objective B cell activating factor (BAFF) is a key regulator of Primary
Sjögren’s Syndrome (pSS), which is characterized by B lymphocyte
hyperactivity. BAFF is also known as TNF ligand superfamily member 13B
(TNFSF13B). This study aimed to explore whether five single nucleotide
polymorphisms (SNPs) of the TNFSF13B gene (rs9514827, rs1041569,
rs9514828, rs1224141, and rs12583006) are related to pSS susceptibility.
Methods We searched Pubmed, Cochrane, Elsevier, Web of Science, CNKI,
CQVIP, and WanFang databases (up to January 2023). In a population with
pSS, the odds ratios (ORs) with 95% confidence intervals (CIs) of
genotypes and each allele were provided to investigate relationships
between the polymorphisms of the BAFF (TNFSF13B) gene and pSS. Results
The meta-analysis in question contains three studies. In the group of
pSS patients and randomly selected health controls (HCs), there was a
statistically significant relationship between rs1041569 and rs12583006
and pSS susceptibility, respectively. In fixed models, there were
statistical differences in pSS patients and randomly chosen HCs.
Conclusions There were relationships of rs1041569 and rs12583006 in the
pSS group and HC group. BAFF(TNFSF13B) genes, particularly rs1041569 and
rs12583006, were related to pSS susceptibility in pSS patients.