Subclinical atherosclerosis in rheumatoid arthritis patients of the Gulf Cooperated Council

Hannawi, Suad; Hannawi, Haifa; Alokaily, Fahda; Salmi, Issa Al

doi:10.15537/smj.2020.9.25319

Cited by 10 publications

(11 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our previous study, carotid atherosclerosis (atherosclerotic plaques in carotid arteries) was diagnosed in 55.4% of patients with early untreated RA mean aged 56 years old, as well as increased mean cIMT over 0.9 mm was detected in 51.4% of RA patients [ 33 ]. According to other authors, subclinical carotid atherosclerosis was found in 21–46% of patients with RA [ 34 , 35 , 36 ]. The progression of atherosclerosis in carotid arteries was observed 3–5-fold more in patients with RA than in individuals without autoimmune diseases [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 94%

Subclinical Carotid Atherosclerosis in Patients with Rheumatoid Arthritis at Low Cardiovascular Risk

et al. 2023

View full text Add to dashboard Cite

Objective: To evaluate the rate of subclinical carotid atherosclerosis and clinical significance of immunoinflammatory markers in patients with rheumatoid arthritis (RA) at low cardiovascular risk. Materials and Methods: The study included 275 RA patients and a control group of 100 participants without autoimmune diseases. All study participants were at low cardiovascular risk, calculated by the QRISK3 scale (<20%), and free of cardiovascular disease. Ultrasound examination of carotid arteries was performed to measure cIMT and to detect atherosclerotic plaques (ASP) in carotid arteries. sIСАМ-1, sVСАМ, and sCD40L levels were determined by enzyme immunoassay. Results: Carotid ASP was observed more frequently in RA patients (27%) than in the control group (17%), p = 0.03. The frequency of ASP in RA patients did not depend on the disease’s stage or activity. There was a significant correlation between cIMT and age, cardiovascular risk determined by QRISK3, level of total cholesterol, LDL, and blood pressure in RA patients, p < 0.05 in all cases. No correlation between cIMT and blood levels of sCD40L, sVCAM, and sICAM was found. In RA patients, a higher concentration of sVCAM was detected in the carotid ASP group compared to the non-atherosclerotic group. sCD40L was associated with cIMT and total cholesterol in the ASP group and with total cholesterol and blood pressure in non-atherosclerotic patients. Conclusions: Subclinical atherosclerotic lesions of the carotid arteries were observed significantly more frequently in RA patients with low cardiovascular risk than in the control group. The results of the study demonstrate the association between cIMT, traditional cardiovascular risk factors, and immunoinflammatory markers in RA patients.

show abstract

Section: Discussionmentioning

confidence: 94%

Subclinical Carotid Atherosclerosis in Patients with Rheumatoid Arthritis at Low Cardiovascular Risk

et al. 2023

View full text Add to dashboard Cite

show abstract

“…In a cross-sectional study by Hannawi et al , patients with RA had significantly higher cIMT values and a higher carotid plaque burden compared to healthy controls. 38 Krajnc et al also found that patients with RA had a higher cIMT compared with controls, suggesting atherosclerotic plaque build-up and increased risk for subsequent CVD. 39 A plethora of other studies included in this review reported similar findings and concluded that there is a high prevalence of premature atherosclerosis in patients with RA.…”

Section: Discussionmentioning

confidence: 95%

Accelerated atherosclerosis in rheumatoid arthritis: a systematic review

Thomas

Gorantla

2022

F1000Res

View full text Add to dashboard Cite

Background: Rheumatoid arthritis (RA) is a highly prevalent, chronic inflammatory condition of the synovial joints that affects approximately 1% of the global population. The pathogenesis of RA is predominantly inflammatory in nature, thereby accelerating the co-occurrence of other immunoinflammatory conditions such as atherosclerosis. Apart from traditional cardiovascular risk factors, RA patients possess a multitude of other factors that predispose them to early atherosclerotic disease. The aim of this systematic review is to assess the prevalence of premature atherosclerosis in RA patients and elucidate the role that proinflammatory cytokines, neutrophil extracellular traps, RA-related autoantibodies, and endothelial dysfunction play in the pathophysiology of RA-mediated atherosclerosis. We also discussed novel biomarkers that can be used to predict early atherosclerosis in RA. Methods: This review followed the PRISMA guidelines to select and analyze relevant articles. A literature search for articles was performed on February 25, 2022, through three research databases including PubMed, ProQuest, and ScienceDirect. The query used to identify relevant publications was “Rheumatoid arthritis and atherosclerosis” and the search duration was set from 2011-2022. Relevant articles were selected based on the inclusion and exclusion criteria. Results: Our initial search generated 21,235 articles. We narrowed our search according to the inclusion and exclusion criteria. After assessing eligibility based on the full content of the articles, 73 articles were ultimately chosen for this review. Conclusion: There is a high prevalence of accelerated atherosclerosis among RA patients. We found evidence to explain the role of proinflammatory cytokines, neutrophil extracellular traps, RA-related autoantibodies, and endothelial dysfunction in the pathophysiology RA-mediated atherosclerosis. Therapies targeting either the inflammatory load or traditional CV risk-factors seem to improve vascular outcomes in RA patients. Novel markers of atherosclerosis in RA may be useful in predicting premature atherosclerosis and serve as new targets for therapeutic intervention.

show abstract

“…Высокая распространенность субклинического атеросклероза у пациентов с РА показана в ряде исследований [33,34]. АСБ сонных артерий диагностированы у 21-46% [35][36][37], по нашим данным, -у 30% больных. Причем проявления бессимптомного атеросклероза сонных артерий выявлены у больных РА с низким ССР [35].…”

Section: Discussionunclassified

“…Зависимость показателя КИМ от традиционных факторов ССР (пол, возраст, ИМТ, уровень САД и ДАД) продемонстрирована в ряде исследований [35,37,38]. Выявленные нами ассоциации толщины КИМ сонных артерий с уровнями скорости оседания эритроцитов и ИЛ-6 соответствуют результатам других работ [39][40][41].…”

Section: Discussionunclassified

Application of cardiovascular risk scales to identify carotid atherosclerosis in patients with rheumatoid arthritis

Gerasimova

Владимировна²,

Попкова

et al. 2021

Terapevticheskii arkhiv

View full text Add to dashboard Cite

Aim. To evaluate the cardiovascular risk (CVR) and analyze its relationship with detection of early carotid artery atherosclerotic lesion in patients with rheumatoid arthritis (RA). Materials and methods. One hundred and nine RA patients aged 45 to 60 without established cardiovascular diseases (CVD) were included in the study. The median age was 52 [48; 54] years, duration of RA was 120 [36; 204] months, DAS28 was 4.7 [3.5; 5.6] points. CVD risk was calculated with mSCORE, Reynolds Risk Score (RRS), ASSIGN, QRISK3, ERS-RA scales and Carotid Artery Doppler Ultrasound Exam was performed for all patients. Results. High risk was found in 5, 5, 14, 6, and 38% of patients according to mSCORE, RRS, ASSIGN, QRISK3, ERS-RA scales, respectively. Atherosclerotic plaques of carotid arteries were found in 30% of patients. It was found that carotid intima-media thickness is correlated to all CVR calculators, age, systolic and diastolic blood pressure, cholesterol, erythrocyte sedimentation rate, interleukin-6 levels. The sensitivity and specificity of the CVR algorithms in prognostication of atherosclerotic carotid artery lesions were 73 and 67% for mSCORE, 64 and 63% for RRS, 64 and 56% for ASSIGN, 73 and 49% for QRISK3, respectively, p0.05 in all cases, 67 and 50% for ERS-RA, p=0.06. Conclusion. RRS, mSCORE, ASSIGN, QRISK3 calculators equally predict atherosclerotic carotid artery damage in RA patients. The optimal ratio of specificity and sensitivity is shown for the mSCORE scale. Stratification of CVR in RA patients should include assessment of the carotid intima-media thickness. To identify CVR in RA patients, the most informative methods are mSCORE calculation and carotid intima-media thickness determination.

show abstract

Subclinical atherosclerosis in rheumatoid arthritis patients of the Gulf Cooperated Council

Cited by 10 publications

References 9 publications

Subclinical Carotid Atherosclerosis in Patients with Rheumatoid Arthritis at Low Cardiovascular Risk

Subclinical Carotid Atherosclerosis in Patients with Rheumatoid Arthritis at Low Cardiovascular Risk

Accelerated atherosclerosis in rheumatoid arthritis: a systematic review

Application of cardiovascular risk scales to identify carotid atherosclerosis in patients with rheumatoid arthritis

Contact Info

Product

Resources

About