Subclinical Atherosclerosis Burden by 3D Ultrasound in Mid-Life

López-Melgar, Beatriz; Fernández‐Friera, Leticia; Oliva, Belén; García-Ruiz, José M.; Peñalvo, José L.; Gómez-Talavera, Sandra; Sánchez‐González, Javier; Mendiguren, José M.; Ibáñez, Borja; Fernández‐Ortíz, Antonio; Sanz, Javier; Fuster, Valentín

doi:10.1016/j.jacc.2017.05.033

Cited by 107 publications

(63 citation statements)

References 42 publications

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“…Several interesting observations can be made about this study. First, no differences in global atheroma burden were found between men and women, which is in contrast to a recent study in which subclinical atherosclerosis burden was assessed by using a three-dimensional vascular US protocol for volumetric quantification of plaque burden (6). Furthermore, the authors also found an association between global atheroma burden and socioeconomic deprivation.…”

Section: Disclosures Of Conflicts Ofcontrasting

confidence: 65%

Whole-Body MR Angiography: Assessing the Global Burden of Cardiovascular Disease

Leiner

2018

Radiology

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Section: Disclosures Of Conflicts Ofcontrasting

confidence: 65%

Whole-Body MR Angiography: Assessing the Global Burden of Cardiovascular Disease

Leiner

2018

Radiology

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“…US images were acquired with linear high frequency 2D and 3D transducers (Philips Transducer L9-3, Philips Healthcare). The BioImage Study protocol was used for the carotid arteries 16 together with a specifically designed protocol for the femoral arteries that encompasses the last 20 mm segment of the common femoral artery. 24 Plaque was defined as a focal structure protruding >0.5 mm into the lumen or reaching a thickness >50% of the surrounding IMT or when the IMT was !1.5 mm.…”

Section: Acquisition Of Subclinical Atherosclerosis Imagingmentioning

confidence: 99%

“…15 The availability of a new three dimensional (3D) US method for arterial scanning promised to improve plaque detection and plaque burden quantification, assumed as the sum of volume of all plaques detected in peripheral arteries for every subject. 16 Compared with two dimensional (2D) US, 3D US allows the arterial circumference section to be explored almost entirely and provides information on other potentially important characteristics of the plaque, such as the density of the atherosclerotic lesions. 17 Plaque burden measured by 3D US in carotid and femoral arteries, was associated with CVR factors 18 and CVD.…”

Section: Introductionmentioning

confidence: 99%

Three Dimensional Carotid and Femoral Ultrasound is not Superior to Two Dimensional Ultrasound as a Predictor of Coronary Atherosclerosis Among Men With Intermediate Cardiovascular Risk

Jarauta

Laclaustra

Villa-Pobo

et al. 2020

European Journal of Vascular and Endovascular Surgery

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WHAT THIS STUDY ADDS Detection of atherosclerotic plaques by two dimensional (2D) carotid artery ultrasound has demonstrated predictive value for cardiovascular disease in the general population. Three dimensional (3D) ultrasound is a novel technique that may improve plaque detection inasmuch as it allows exploration of almost the entire section of the artery wall. However, in this study, 3D ultrasound showed no higher sensitivity to detect plaques nor did it add any predictive value of coronary artery calcium to 2D ultrasound among a sample of 120 subjects with intermediate cardiovascular risk. Therefore, the use of 2D ultrasound is recommended for cardiovascular risk stratification in subjects with intermediate cardiovascular risk. Background: Current cardiovascular disease (CVD) risk stratification scales, drawn up from traditional risk factors, have important limitations. The detection of subclinical atherosclerosis, by a non-invasive technique such as peripheral arteries ultrasound (US) may improve cardiovascular risk (CVR) stratification, especially in intermediate risk population. Our aim was to compare the predictive power of atherosclerotic plaques detected in carotid and femoral arteries by 2-dimensional (2D) vs. 3-dimensional (3D) US for positive coronary artery calcium score (CACS), used as a proxy for CVD, in a middle-aged sample with intermediate 10-year CVR (7.5e20%). Methods: To detect atherosclerotic plaques by 2D vs. 3D US scan of carotid and femoral arteries and comparison of their association with CACS obtained by computed tomography (CT) of subjects with intermediate CVR belonging to the Aragon Workers' Health Study. Results: 120 men were included, with a 10.4% average 10 years CVR. Forty-one (34.2%) participants had CACS ! 1. 90 participants (75%) had at least one plaque detected by 2D scan while 85 participants (70.8%) had at least a plaque detected by 3D US. Conventional CVR estimates c-statistic for CACS was .590. Although the variables most predicted of CACS ! 1 were those measured by 3D US (total plaque volume and mean of plaque density, cstatistics: .743 and .750 respectively), their predictive capacity was not statistically significantly different from the number of territories with plaque, measured either by 2D and 3D US (c-statistics .728 to .740 respectively). Conclusion: Subclinical atherosclerosis measured by 2D and 3D US were better predictors of CACS ! 1 than CVR estimated by conventional guidelines. In our sample, 3D US did not show any significant advantages with respect to 2D US for the prediction of coronary atherosclerosis.

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“…Inspired by the previous study and as data supplement for current research from China, the present study including in-hospital participants (mean age 67.40 years, 61.0% CAD, 39.8% stroke, 30.8% PAD, 74.1% hypertension, 38.4% diabetes, 73.9% dyslipidemia, 3.4% without any above diseases), only about 7% were free of atherosclerosis in any of the three vascular sites, and the prevalence of multi-site atherosclerotic plaques was 74.4% which was similar to other studies. To further evaluate the prevalence in different vessel bed, we found in the studied population from China, with carotid plaque was the most common, which was different from the PESA in which presence of iliofemoral artery was the most common [12,13] . The main reasons are that the study population (asymptomatic vs high-risk participants) and different high incidence diseases (coronary heart disease vs stoke) vary from other country to China.…”

Section: The Prevalence Of Multi-site Atherosclerotic Plaquesmentioning

confidence: 99%

Association between multi-site atherosclerotic plaques and systemic arteriosclerosis: results from the BEST study (Beijing Vascular Disease Patients Evaluation Study)

liu

Wang

Huang

et al. 2020

Preprint

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Background Arteriosclerosis can be reflected in various aspect of the artery, including atherosclerotic plaque formation or stiffening on the arterial wall. Both arteriosclerosis and atherosclerosis are important and closely associated with cardiovascular disease (CVD). The aim of the study was to evaluate the association between systemic arteriosclerosis and multi-site atherosclerotic plaques. Methods The study was designed as an observational cross-sectional study. A total of 1178 participants (mean age 67.4 years; 52.2% male) enrolled into the observational study from 2010 to 2017. Systemic arteriosclerosis was assessed by carotid femoral artery pulse wave velocity (CF-PWV) and multi-site atherosclerotic plaques (MAP, >=2 of the below sites) were reflected in the carotid or subclavian artery, abdominal aorta and lower extremities arteries using ultrasound equipment. The associations were assessed by multivariable logistic regression. Results The prevalence of CF-PWV >12 m/s and MAP were 40.2% and 74.4%. Atherosclerotic plaques in 3 sites were more common in male compared with that in female (48.9% versus 36.9%, p<0.05). All CVD factors were worse in participants with MAP than that with <=1 site. Participants with CF-PWV>12m/s corresponded to a mean 82% probability of MAP with age and sex-adjusted. Patients with peripheral artery disease showed the highest odds ratio (OR) (3.88) for MAP, followed by smoking (2.485), CF-PWV>12m/s (2.25), dyslipidemia (1.89), male (1.84), stroke (1.64), hypoglycemic agents (1.56) and age (1.09) (all p<0.001). Conclusions MAP was highly prevalent in this cohort, with male showing a higher prevalence than female. Higher systemic arteriosclerosis was independently associated with MAP, which indicating the supplementary value of arteriosclerosis for the earlier identification and intervention on MAP.Trial registration: Clinical Trial, URL: http://www.clinicaltrials.gov. Unique identifier: NCT02569268

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Subclinical Atherosclerosis Burden by 3D Ultrasound in Mid-Life

Cited by 107 publications

References 42 publications

Whole-Body MR Angiography: Assessing the Global Burden of Cardiovascular Disease

Whole-Body MR Angiography: Assessing the Global Burden of Cardiovascular Disease

Three Dimensional Carotid and Femoral Ultrasound is not Superior to Two Dimensional Ultrasound as a Predictor of Coronary Atherosclerosis Among Men With Intermediate Cardiovascular Risk

Association between multi-site atherosclerotic plaques and systemic arteriosclerosis: results from the BEST study (Beijing Vascular Disease Patients Evaluation Study)

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