Subclinical atherosclerosis and hyperandrogenemia are independent risk factors for increased epicardial fat thickness in patients with PCOS and idiopathic hirsutism

Çakır, Evrim; Doğan, Mehmet; Topaloğlu, Oya; Özbek, Mustafa; Çakal, Erman; Vural, Mutlu; Yeter, Ekrem; Delibaşı, Tuncay

doi:10.1016/j.atherosclerosis.2012.11.004

Cited by 45 publications

(39 citation statements)

References 26 publications

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“…With this finding, it is reasonable to consider that body hair status in the present is not an independent variable and that, by quantifying current body hair, information may be obtained regarding body hair in the past. This information may be relevant for identifying women who were exposed to a hyperandrogenic state over a considerable period of time, with all the cardiometabolic consequences that may result from this hormonal environment (33,34). Data from this study confirm that, over time, facial hair increases in women, while on the thighs body hair decreases.…”

Section: Marks From the Past In The Presentsupporting

confidence: 74%

A simplified questionnaire for self-assessment of hirsutism in population-based studies

Gabrielli

Aquino

2015

European Journal of Endocrinology

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Objective: The measurement of excess body hair is not straightforward. As the modified Ferriman-Gallwey (mFG) score is unsuitable for self-assessment and requires specialist training, a short, self-administered questionnaire to identify hirsutism was constructed and validated for large-scale application, particularly targeting population-based studies. Design: A validation study was conducted to assess a new hirsutism questionnaire. Methods: A total of 90 women aged 35-72 years who were enrolled in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) were evaluated. A self-administered instrument containing four questions was designed to evaluate five body areas: upper lip, chin, chest, lower abdomen, and thighs with respect to the current distribution of body hair and that before 35 years of age. A score of 0-4 was attributed to each region based on drawings provided in the instrument. Test-retest reliability was evaluated by reformulating the initial questions. An independent medical examination was conducted to apply the gold standard, the mFG score. Results: The area under the receiver operating characteristic curve was 0.93 (95% CI: 0.87-0.99). A cut-off score of 5 showed the best balance between sensitivity (85%) and specificity (90%), with 88.9% accuracy. Spearman's correlation between current and past body hair score was calculated at 0.82 (PZ0.000), and showed a test-retest reliability of 0.49, with a trend toward similar answers regarding changes in the quantity of body hair over time, irrespective of how the questions were asked (PZ0.000). Conclusion: The accuracy and internal consistency of this self-administered questionnaire for the identification of hirsutism were good. Therefore, this questionnaire represents a useful tool for self-assessment of hirsutism in population-based studies.

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Section: Marks From the Past In The Presentsupporting

confidence: 74%

A simplified questionnaire for self-assessment of hirsutism in population-based studies

Gabrielli

Aquino

2015

European Journal of Endocrinology

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“…EFT measurement was performed in only parasternal long-axis view in our study. In the current literature, there are reported data evaluating echocardiographic EFT from the parasternal long-axis view as in line with our study [12,17]. Since these issues have been confirmed in previous reports, EFT was measured by an experienced echocardiologist from the parasternal long-axis view in our study.…”

supporting

confidence: 73%

“…Therefore, echocardiographic EFT can be applied as an easy and reliable imaging indicator of cardiovascular risk [13]. Many previous studies [10,12,13,14,15,16,17] have evaluated EFT with the help of echocardiography by a method similar to that used in our study.…”

mentioning

confidence: 99%

“…The aim of our study was not to test the inter- and intraobserver reliability of echocardiographic EFT measurement, which has already been demonstrated in several studies [14,15,16]. Furthermore, there are noteworthy studies evaluating echocardiographic EFT by a single observer's measurements [17,18]. EFT measurement was performed in only parasternal long-axis view in our study.…”

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Akyıldız

Nazlı²

2014

Dermatology

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“…В одном из исследований была доказана взаимосвязь тЭЖТ с субклиническим атеросклерозом коронарных арте-рий [22]. Положительная корреляция между тЭЖТ и ТКИМ ОСА была выявлена у женщин с синдромом поликистозных яичников [23].…”

Section: Discussionunclassified

Risk Prediction for Subclinical Atherosclerotic Lesion of Brachiocephalic Arteries in Obese Women

Шенкова¹,

Веселовская²,

Чумакова³

et al. 2017

Russ J Cardiol

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54Заболеваемость и смертность от сердечно-сосудис тых заболеваний (ССЗ) занимает первое место во многих странах мира, в том числе и в России [1]. Поэтому профилактика ССЗ, особенно в группах высокого риска, является приоритетным направле-нием современной кардиологии.Одна из таких групп высокого риска -пациенты с ожирением. Женщины, как правило, имеют более высокую степень ожирения на протяжении всей жизни, этот фактор риска (ФР) у женщин имеет боль-шое социальное значение, так как связан с наруше-нием репродуктивного здоровья, осложнением тече-ния беременности и возможной неонатальной забо-леваемостью [2,3]. Ряд исследований свидетельствуют о высокой встречаемости субклинического атеро-склероза магистральных артерий среди бессимптом- Шенкова Н. Н. -врач-кардиолог, Веселовская Н. Г. -д. м.н., зав. кардиологи-ческим отделением № 4, Алтайского краевого кардиологического диспансера, с. н.с. отдела мультифокального атеросклероза, Чумакова Г. А.* -д. м.н., про-фессор кафедры терапии и общей врачебной практики ФПК и ППС, в. н.с. отдела мультифокального атеросклероза, Осипова Е. С. -спирант кафедры терапии и общей врачебной практики ФПК и ППС, Гриценко О. В. -к. м.н., врач-кардиолог, Отт А. В. -врач-кардиолог Алтайского краевого кардиологи-ческого диспансера. ПРОГНОЗИРОВАНИЕ РИСКА СУБКЛИНИЧЕСКОГО АТЕРОСКЛЕРОЗА БРАХИОЦЕФАЛЬНЫХ АРТЕРИЙ У ЖЕНЩИН С ОЖИРЕНИЕМ*Автор, ответственный за переписку (Corresponding author): g. a.chumakova@mail.ru ССЗ -сердечно-сосудистые заболевания, ФР -факторы риска, ИБС -ише-мическая болезнь сердца, ЭЖТ -эпикардиальная жировая ткань, ВЖТ -вис-церальная жировая ткань, БЦА -брахиоцефальные артерии, СД -сахарный диабет, ИМТ -индекс массы тела, ТКИМ -толщина комплекса интима медиа, АБ -атеросклеротическая бляшка, САД -систолическое артериальное дав-ление, ОИМ -острый инфаркт миокарда, тЭЖТ -толщина эпикардиальной жировой ткани, ВО -висцеральное ожирение. Aim. To reveal the complex of metabolic risk factors, most significantly related to subclinical atherosclerosis of brachiocephalic arteries (BCA) in obese women. Material and methods. Totally, 89 women included, at the age 25-59 y. o. (50,6±6,6 y. o.) with abdominal obesity -waist circumference >80 cm with no clinical signs of coronary heart disease and atherosclerosis of other localizations. All women underwent duplex DCA scanning with the intima-media thickness assessment (IMT). Also, the main metabolic risk factors were assessed, adipokines of visceral fat tissue, ghrelin. Epicardial fat thickness (tEFT) in millimeters was measured by echo. Veloergometry was performed, to rule out angina and silent myocardial ischemia; cardiovascular risk assessment by SCORE, Framingham, PROCAM. Results. In 32,6% women there were signs of BCA atherosclerosis (IMT more than 1,3-1,5 mm). An equation was invented for logistic regression with the most significant predictors group (ghrelin, CRP, tEFT, leptin), related to subclinical BCA atherosclerosis in obese women, with sensitivity 89,7%. Conclusion. The complex of RF that were collected, might be used in clinical p...

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Subclinical atherosclerosis and hyperandrogenemia are independent risk factors for increased epicardial fat thickness in patients with PCOS and idiopathic hirsutism

Cited by 45 publications

References 26 publications

A simplified questionnaire for self-assessment of hirsutism in population-based studies

A simplified questionnaire for self-assessment of hirsutism in population-based studies

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Risk Prediction for Subclinical Atherosclerotic Lesion of Brachiocephalic Arteries in Obese Women

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