Subclinical atherosclerosis and arterial stiffness in nonalcoholic fatty liver disease: A case-control study in Algerian population

Taharboucht, S.; Guermaz, R.; Brouri, M.; Chibane, A.

doi:10.1016/j.jdmv.2021.03.008

Cited by 7 publications

(5 citation statements)

References 59 publications

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“…1 ). The studies included were conducted in various countries including Algeria [ 31 ], China [ 32 - 39 ], Croatia [ 40 ], Egypt [ 41 , 42 ], Greece [ 43 , 44 ], India [ 45 - 49 ], Iran [ 50 - 57 ], Italy [ 58 - 66 ], Japan [ 67 , 68 ], Malaysia [ 69 , 70 ], Romania [ 71 ], Serbia [ 72 ], South Korea [ 73 - 78 ], Spain [ 79 , 80 ], Taiwan [ 81 ], Turkey [ 82 - 92 ], USA [ 93 , 94 ]. Additionally, one study [ 95 ] was a multicentre study based in Egypt [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

“…A total of 135,602 patients were included in our analysis with 47,322 patients with NAFLD and 88,280 non-NAFLD controls. NAFLD defined by liver biopsy [ 44 , 82 , 84 , 86 , 87 , 90 , 92 ] was found in seven studies, and by non-invasive methods, including ultrasonography [ 31 - 43 , 45 - 81 , 83 , 85 , 86 , 88 , 89 , 91 , 93 ] in 57 studies and CT scan [ 94 ] in one study. All studies were assessed to have a high (n=46) or moderate (n=18) quality based on the JBI Critical Appraisal Checklist assessment tool ( Supplementary Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

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Non-alcoholic fatty liver disease increases risk of carotid atherosclerosis and ischemic stroke: An updated meta-analysis with 135,602 individuals

et al. 2022

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Background & Aims:Non-Alcoholic Fatty Liver Disease (NAFLD) is associated with the development of cardiovascular disease. While existing studies have examined cardiac remodeling in NAFLD, there has been less emphasis on the development of carotid atherosclerosis and stroke. We sought to conduct a metaanalysis to quantify the prevalence, risk factors and degree of risk increment of carotid atherosclerosis and stroke in NAFLD. Methods:Embase and Medline were searched for articles relating to NAFLD, carotid atherosclerosis, and stroke.Proportional data was analysed using a generalized linear mixed model. Pairwise meta-analysis was conducted to obtain odds ratio or weighted mean difference for comparison between patients with and without NAFLD. Results:From pooled analysis of 30 studies involving 7,951 patients with NAFLD, 35.02% (95%CI: 27.36% to 43.53%) had carotid atherosclerosis with an odds ratio of 3.20 (95%CI: 2.37 to 4.32; p<0.0001).Pooled analysis of 25,839 patients with NAFLD found the prevalence of stroke to be 5.04% (95%CI: 2.74% to 9.09%) with an odds ratio of 1.88 (95%CI: 1.23 to 2.88; p=0.02) compared to non-NAFLD.The degree of steatosis assessed by ultrasonography in NAFLD was closely associated with increment in odds of carotid atherosclerosis and stroke. Older age significantly increased the odds of developing carotid atherosclerosis but not stroke in NAFLD. Conclusions:This meta-analysis shows that a stepwise increment of steatosis of NAFLD can significantly increase the odds of carotid atherosclerosis and stroke development in NAFLD. More than a third suffer from carotid atherosclerosis and routine assessment of carotid atherosclerosis is quintessential in NAFLD.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Non-alcoholic fatty liver disease increases risk of carotid atherosclerosis and ischemic stroke: An updated meta-analysis with 135,602 individuals

et al. 2022

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“…Therefore, our results may hypothesize on the fact that while isolated, NAFLD and HT may promote the onset of very early vascular alterations they are able to create an evident vascular damage only when coexist, speculating on their synergistic effect. The association between NAFLD and both atherosclerosis and arterial stiffness is well established as depicted by the Multi-Ethnic Study of Atherosclerosis cohort, where the presence of NAFLD was associated with a higher CD and cIMT (47) or by a more recent study, where NAFLD was significantly associated with overt carotid atherosclerosis and arterial stiffness (48). Furthermore, other observational studies reported that NAFLD led to an increased risk of endothelial dysfunction and atherosclerosis in adult male patients, independently of MS (49,50).…”

Section: Discussionmentioning

confidence: 86%

Subclinical and clinical atherosclerosis in non-alcoholic fatty liver disease is associated with the presence of hypertension

Cattazzo

Lombardi

Mantovani

et al. 2022

Nutrition, Metabolism and Cardiovascular Diseases

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“…More recent studies also report associations between fibrosis and atherosclerosis measures cIMT and PWV. A case-control study of fibrosis (ie, not including steatosis alone) in adults aged 30–70 years (n=213 with fibrosis) by Taharboucht et al 32 also reported greater cIMT and greater carotid-femoral PWV in the presence of fibrosis, even after the adjustment for age, sex, smoking, abdominal obesity, overall obesity, hypertension, dyslipidemia, GGT, ALT, insulin resistance, and CRP. These findings by Taharboucht et al 32 are similar to those reported in the present work.…”

Section: Discussionmentioning

confidence: 97%

Non-alcoholic fatty liver and fibrosis is associated with cardiovascular structure and function in young adults

Tang

Abeysekera

Howe

et al. 2023

Hepatology Communications

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Background: Non-alcoholic fatty liver disease shares many risk factors with other metabolic disorders. We sought to establish whether non-alcoholic fatty liver disease may be associated with cardiovascular health independently of other known risk factors. Methods: In this prospective, population-based cohort of young adults, controlled attenuation parameter-defined liver steatosis, transient elastography-defined liver fibrosis, echocardiography, carotid ultrasonography, and pulse wave analysis were assessed at age 24 years. We examined associations between liver and cardiovascular measures, with and without accounting for demographics, body mass index, alcohol, smoking, blood pressure, lipidemia, glycemia, and inflammation. Results: We included 2047 participants (mean age 24.4 y; 36.2% female): 212 (10.4%) had steatosis, whereas 38 (1.9%) had fibrosis. Steatosis was associated with cardiovascular measures after adjusting for demographics, but with more comprehensive adjustment, steatosis only remained associated with stroke index [β (95% CI) of −1.85 (−3.29, −0.41) mL/m 2 ] and heart rate [2.17 (0.58, 3.75) beats/min]. Fibrosis was associated with several measures of cardiovascular structure and function after full adjustment for risk factors, including left ventricular mass index [2.46 (0.56, 4.37) g/m 2.7 ], E/A ratio [0.32 (0.13, 0.50)], tricuspid annular plane systolic excursion [0.14 (0.01, 0.26) cm], carotid intima-media thickness [0.024 (0.008, 0.040) mm], pulse wave velocity [0.40 (0.06, 0.75) m/s], cardiac index [−0.23 (−0.41, −0.06) L/min⋅m 2 ], and heart rate [−7.23 (−10.16, −4.29) beats/min]. Conclusions: Steatosis was not associated with measures of cardiovascular structure and function nor with subclinical atherosclerosis after adjusting for known cardiovascular risk factors. Fibrosis, however, was associated with several cardiovascular measures, including indicators of subclinical atherosclerosis, even after full adjustment. Further follow-up will help determine whether cardiovascular health worsens later with steatosis alone.

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Subclinical atherosclerosis and arterial stiffness in nonalcoholic fatty liver disease: A case-control study in Algerian population

Cited by 7 publications

References 59 publications

Non-alcoholic fatty liver disease increases risk of carotid atherosclerosis and ischemic stroke: An updated meta-analysis with 135,602 individuals

Non-alcoholic fatty liver disease increases risk of carotid atherosclerosis and ischemic stroke: An updated meta-analysis with 135,602 individuals

Subclinical and clinical atherosclerosis in non-alcoholic fatty liver disease is associated with the presence of hypertension

Non-alcoholic fatty liver and fibrosis is associated with cardiovascular structure and function in young adults

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