Subclassification of left ventricular hypertrophy based on dilation stratifies coronary artery disease patients with distinct risk

Abstract

In patients with CAD, dilated LVH and nondilated LVH provide distinct prognostic information. Eccentric nondilated LVH does not predict adverse outcomes.

Impact of Chamber Dilatation on the Prognostic Value of Left Ventricular Geometry in Hypertension

“…In contrast, LVM and relative wall thickness were independent predictors of all‐cause death, cardiovascular death, and hospitalization for heart failure in patients with acute myocardial infarction included in the VALIANT (Valsartan in Acute Myocardial Infarction) echocardiographic study 29. Partially different findings have been reported by Huang and coworkers in a patient population with coronary artery disease undergoing coronary angiography 30. In that study, LV dilatation conferred a higher risk of subsequent cardiovascular events and all‐cause death regardless of the geometric pattern of LVH 30.…”

Association of 4-Tiered Classification of Left Ventricular Hypertrophy With Adverse Cardiovascular Outcomes in the General Population

“…(7,8) Cardiac MRI has improved accuracy and interstudy reproducibility in the assessment of LV mass. (17,18) As such, our results provide further evidence suggesting that indeterminate hypertrophy is a benign phenotype, a finding that has important implications given the strong association of indeterminate hypertrophy with obesity, which is increasingly prevalent in the population.…”

“…Subsequent studies have related the 4-tiered classification system to clinical outcomes in patients with hypertension and coronary artery disease. (7,8) However these studies used echocardiography, which has known limitations in assessing LV mass and LV volume when compared to cardiac magnetic resonance imaging (MRI). (5,9) Moreover, this classification system has not yet been related to clinical outcomes in an unselected general population sample.…”

Myocardium Remodeling and the Risk of Cardiovascular Complications With Patients With Ischemic Heart Disease and Arterial Hypertension

“…Очевидно, что процессы ремоделирования миокарда имели существенное значение в оценке эффективности лечения, профилактики и прогноза больных различными сердечно-сосудистыми заболеваниями [1,2,4,7,8,9,14,15]. Показано, что прогрессирование нарушений геометрии, объема и массы ЛЖ ассоциировалось с ухудшением течения ИБС и АГ [2].…”

“…Показано, что даже через 3 месяца после операции ремоделирование ЛЖ имело место в 24 % наблюдений [8]. Анализ литературных данных показал, что результаты лечения больных во многом были связаны с динамикой параметров ремоделирования сердца [1,15]. При этом благоприятный прогноз больных ИБС и АГ в существенной степени ассоциировался с восстановлением сократительной способности сегментов миокарда.…”