Subchronic toxicity study of herbal tea of Moringa stenopetala (Baker f.) Cudof. and Mentha spicata L. leaves formulation in Wistar albino rats

Prenatal developmental toxicity study of herbal tea of Moringa stenopetala and Mentha spicata leaves formulation in Wistar rats

“…Herbal formulations made from the leaves of M. stenopetala and M. spicata showed better antidiabetic and antihypertensive effects in rodent models. These herbs' leaf formulations were non- or low-toxic to rodents after short and long-term oral administration [30] , [31] , [32] . Nevertheless, the prenatal developmental toxicity potential of herbal (leaves) formulation of these two medicinal plants has not been investigated yet.…”

“…The tea infusions were prepared shortly prior to administration [15] , [30] . The different doses (559.36, 1118.72, and 2237.44 mg/kg body weight) selected for the present study were chosen based on previous studies [15] , [30] , [31] , [32] .…”

“…The Acute Toxic Class Method procedure found the acute oral LD50 of herbal tea in rats to be > 5593.6 mg/kg body weight [30] . The repeated dose 90-day (subchronic) oral toxicity study conducted on male and female rats revealed no herbal tea-induced major toxic events at doses of 559.36, 1118.72, and 2237.44 mg/kg body weight [31] . During the chronic oral toxicity study, both male and female rats treated with different concentrations of herbal tea (up to a high dose of 2237.44 mg/kg/day) showed no in-life adverse events (e.g., death, overt toxic symptoms, loss of body weight, or altered food intake) throughout the 360-day treatment period.…”

A comparative review on the anti-nutritional factors of herbal tea concoctions and their reduction strategies

“…Various pharmacological properties have been found in the leaves, such as sedative, carminative, anti-spasmodic, hypoglycemic action, diuretic action, antimicrobial activity, antioxidant activity, breath problems, and anti-inflammatory action. Typically, M. spicata leaves are prepared as tea infusions to treat high blood pressure, menstrual irregularities, digestive issues, and respiratory problems ( 21 , 54 , 55 ). Spearmint essential oil has been used to treat digestive problems, obesity, asthma, coughing, and colds in traditional Arabic Palestinian medicine.…”

“…It can be used in fresh, dried, or powdered forms as seasonings and teas. Spearmint can be air dried ( 21 ) under shade for processing as herbal tea. The processing of roselle utilizes fruit and calyxes (dried) to be used as herbal tea.…”