Subchronic Toxicity Assessment of Orally Administered Methanol (70%) Seed Extract of &lt;i&gt;Abrus precatorius&lt;/i&gt; L. in Wistar Albino Rats

Tabasum, Shazia; Khare, Swati; Jain, Kirti

doi:10.4274/tjps.87487

Cited by 8 publications

(2 citation statements)

References 10 publications

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“…No significant change in the water consumption of the treated rats was recorded compared to the control. The lack of significant alteration in water intake by the treated rats indicates the non-toxic effect of the extract ( Tabasum et al ., 2019 ). This can be summarized by saying that mortality and water consumption represent very sensitive indicators to evaluate the toxicity of a substance ( Kebede et al ., 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Ecological and oral toxicity assessment of urea and camphor oil against Rattus norvegicus rats

Khater,

Ghareeb

2024

Open Vet J

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Background: One of the most challenging pests to control is the wild rat (Rattus norvegicus), which poses serious risks to both human health and the economy. Fertilizers are a more recent method of pest management with various action modes and are considered safe control agents when applied at low doses. Aim: The present study aimed to examine the toxicological impacts of the contaminated water with urea and camphor oil individually, post-treatment of rats with camphor oil after the pre-treatment with urea and post-treatment of rats with urea mixed with camphor oil after urea pre-treatment against the wild rats (Rattus norvegicus). Methods: The study extends to explore the influence of these treatments on the physicochemical parameters of the water administered by rats. Moreover, the effect of the most three toxic treatments was studied on the blood and renal functional parameters and the kidney tissue of rats after 21 days of treatment. Results: The study showed that urea was more potent than camphor oil when applied individually and increasing the concentration of urea in the pre-treatment or when combined with camphor oil in the post-treatment caused a significant increase in the mortality of rats. The post-treatment of rats with camphor oil only or camphor oil mixed with urea after the pre-treatment with urea induced a synergistic activity against rats. In addition, the exposed water to urea and camphor oil has been modified in physicochemical parameters and formed ulcers and harm to the kidneys of the exposed wild rats. Conclusion: This study significantly contributes to the ecological and toxicological potential risk indexes of urea and camphor oil together, which are restricted on the perceptible value relevance in the literature of water quality and renal pathology. So, urea and camphor oil represent successful agents for the wild rat's control.

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Section: Discussionmentioning

confidence: 99%

Ecological and oral toxicity assessment of urea and camphor oil against Rattus norvegicus rats

Khater,

Ghareeb

2024

Open Vet J

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“…Such studies cautions researchers to assess phytochemicals safety in long-term use. Toxicity studies improve product knowledge by augmenting its utilization and preventing undesirable effects, a major obstacle for long-term use of modern medication (Tabasum et al, 2019). As per Organisation for Economic Co-operation and Development (OECD) TG 407 (OECD, 2008b), sub-acute toxicity study is conducted only after knowing snapshot details from acute toxicity studies.…”

Section: Introductionmentioning

confidence: 99%

Safety evaluation of a proprietary ayruveda-based polyherbal preparation (arthralgex) used for arthritis

Ukkinadka,

Badanthadka

2024

Braz. J. Biol.

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Arthralgex is a proprietary polyherbal preparation used in clinics to treat rheumatoid arthritis for decades. Its safety evaluation has not been reported. The study is aimed at evaluating the safety of arthralgex using Wistar rats, as per OECD guidelines. According to OECD 407, rats of either gender were separated into six groups (n= 6 each). The dose of arthralgex was decided based on an acute toxicity study. Under the treatment group, separate set of rats received arthralgex in three dose levels like - low, medium, and high (200, 400 & 800 mg/kg/day; p.o for 28 days). Satellite groups received high dose (800 mg/kg/day, p.o for 28 days), and control group received equal volume of vehicle. On day 28, blood samples were collected to estimate hematology and biochemistry parameters. Subsequently, rats were euthanized to collect organs for weighing and histopathology. Satellite groups were maintained for an additional 14 days post-treatment to assess toxicity reversibility and euthanized on day 43. Arthralgex did not show any signs of toxicity or major change in body weight in the acute toxicity study. Arthralgex has no significant adverse effect on general health status as confirmed by body weight, feed intake, hematology, biochemistry, urine analysis, internal organs, relative organ weight, and histopathological evaluation after 28 day treatment. Arthralgex could be considered safe for short-term treatment. Present findings may help researchers in dose fixing for sub-chronic and chronic toxicity studies, which is essential for safety evaluation for long-term use.

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Systematic review on Abrus precatorius Linn. since 1871: ethnobotanical uses, phytochemistry and pharmacological properties

Vijayan,

Thirumal

2024

Phytochem Rev

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Subchronic Toxicity Assessment of Orally Administered Methanol (70%) Seed Extract of <i>Abrus precatorius</i> L. in Wistar Albino Rats

Cited by 8 publications

References 10 publications

Ecological and oral toxicity assessment of urea and camphor oil against Rattus norvegicus rats

Ecological and oral toxicity assessment of urea and camphor oil against Rattus norvegicus rats

Safety evaluation of a proprietary ayruveda-based polyherbal preparation (arthralgex) used for arthritis

Systematic review on Abrus precatorius Linn. since 1871: ethnobotanical uses, phytochemistry and pharmacological properties

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