Subchronic oral toxicity of zinc in rats

Llobet, Juan M.; Domingo, José L.; Colomina, María Teresa; Mayayo, Emilio; Corbella, Jacint Corbella i

doi:10.1007/bf01689056

Cited by 56 publications

(45 citation statements)

References 10 publications

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“…In our study, the stability of the ALT, AST, LDH and CK levels in the three zinc groups compared to the control rats (table 4) indicated that the hepatic and cardiac functions were not damaged after a daily treatment with zinc gluconate at a 4 mg/kg dose [28], in accordance with a previous study that showed a significant decrease in AST only after 8 mg/kg zinc treatment, but not in the 4 mg/kg zinc group [14]. Finally, as the blood urea and creatinine levels did not fall in any group, we did not notice any renal dysfunction until the 4 mg/kg dose of zinc gluconate, although these results are inconsistent with other studies [10].…”

Section: Discussionsupporting

confidence: 85%

“…These findings indicate that excessive intake of zinc supplements is also a potential risk to human beings. Studies on rats have shown that excessive dietary zinc in these animals induces deficiencies of copper and iron, producing poor growth and anaemia [9,10]. In rats, the oral lethal dose 50 (LD 50 ) for zinc salts is 237-623 mg/kg, the intraperitoneal injection LD 50 is 28-73 mg/kg and the inhalation LD 50 for zinc chloride is 2000 m 3 [11][12][13].…”

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confidence: 99%

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Toxic Effects of Iterative Intraperitoneal Administration of Zinc Gluconate in Rats

Andriollo-Sanchez¹,

Claeyssen²,

Arnaud³

et al. 2008

Basic Clin Pharma Tox

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Although zinc is an essential trace element involved in many physiological functions, toxicological data concerning acute exposure are scarce. The aim of our study was to determine the maximal iterative dose of zinc that can be administrated in rats without any adverse effect. Saline (control group) or zinc gluconate at 1, 2 or 4 mg/kg were intraperitoneally injected in animals daily during 7 days. The tolerance of zinc treatments was evaluated by the observation of clinical symptoms, haematological parameters and biochemistry, in relation to the zinc and copper levels in blood, liver, pancreas and faeces. We found no serious adverse effect within 1 week in rats injected intraperitoneally with 1 or 2 mg/kg/day of zinc gluconate, which tends to indicate that those doses could be useful in future therapeutic research. In contrast, the therapeutic treatment of adult rats with repeated intraperitoneal injections of a 4 mg/kg/day zinc dose should be cancelled, due to the occurrence of clinical adverse effects within a few days, as intraperitoneal local intolerance or major growth underdevelopment.

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Section: Discussionsupporting

confidence: 85%

mentioning

confidence: 99%

Toxic Effects of Iterative Intraperitoneal Administration of Zinc Gluconate in Rats

Andriollo-Sanchez¹,

Claeyssen²,

Arnaud³

et al. 2008

Basic Clin Pharma Tox

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“…[7]. Natural water supplies usually contain only trace amounts of zinc, but the concentration may increase if the water flows through galvanized, copper, or plastic pipes [8].…”

Section: Introductionmentioning

confidence: 99%

Flame Atomic Absorption Spectrometry Determination of Trace Amounts of Cadmium and Zinc in Water Samples after Preconcentration onto Modified Amberlite XAD‐4 Resin

Mohammadi¹,

Afzali²,

Taher

et al. 2010

CLEAN Soil Air Water

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In the present article, a procedure for the simultaneous separation and preconcentration of trace amounts of cadmium and zinc is proposed. It is based on the adsorption of cadmium and zinc ions onto a column of Amberlite XAD-4 resin loaded with aluminon reagent. Cadmium and zinc ions are quantitatively retained on the column in the pH range from 6.5 -7.5, at a flow rate of 2 mL min , respectively. The interference of a large number of anions and cations has been studied and the optimized conditions are utilized for the determination of trace amounts of cadmium and zinc in different environmental and standard samples.

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“…Although Zn is generally considered to be relatively nontoxic to animals, 17,20 Zn poisoning has been reported in numerous species. 1,7,13,17,29 Zinc toxicities and deficiencies are frequently complicated by the antagonistic relationship between Zn, Cu, and Fe.…”

Section: Discussionmentioning

confidence: 99%

Toleration of High Concentrations of Dietary Zinc by Mink

et al. 1991

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Adult and kit male and female natural dark ranch mink (Mustela vison) were fed a conventional diet supplemented with 0, 500, 1,000, or 1,500 ppm zinc, as ZnSO4.7H2O, for 144 days. No marked adverse effects were observed in feed consumption, body weight gains, hematologic parameters, fur quality, or survival. Zinc concentrations in liver, kidney, and pancreas of the mink increased in direct proportion to the zinc content of the diet. Histopathologic examination of the livers, kidneys, and pancreata revealed no lesions indicative of zinc toxicosis. The results indicate that mink can tolerate at least 1,500 ppm dietary zinc, as ZnSO4.7H2O, for several months without apparent adverse effects.

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Subchronic oral toxicity of zinc in rats

Cited by 56 publications

References 10 publications

Toxic Effects of Iterative Intraperitoneal Administration of Zinc Gluconate in Rats

Toxic Effects of Iterative Intraperitoneal Administration of Zinc Gluconate in Rats

Flame Atomic Absorption Spectrometry Determination of Trace Amounts of Cadmium and Zinc in Water Samples after Preconcentration onto Modified Amberlite XAD‐4 Resin

Toleration of High Concentrations of Dietary Zinc by Mink

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