Subchronic Inhalation Study of 1-Hexene in Fischer 344 Rats

Gingell, Ralph; Bennick, Jerry E.; Malley, Linda A.

doi:10.3109/01480549909042529

Cited by 6 publications

(4 citation statements)

References 7 publications

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“…There was no difference in the neuromuscular function at any exposure level. Serum phosphorus was the only clinical chemistry value that was statistically associated with exposure in a dose-related fashion in both sexes (413).…”

Section: Chronic and Subchronic Toxicitymentioning

confidence: 98%

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Aliphatic Hydrocarbons

Carreón¹,

Herrick²

2012

Patty's Toxicology

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Aliphatic hydrocarbons are open‐chain compounds that may be saturated or unsaturated. The saturated compounds, known as paraffin hydrocarbons or alkanes , include methane and its homologs having the empirical formula C n H 2 n +2 . The unsaturated compounds fall into a number of homologous series: ( 1 ) those containing one double bond (ethylene and its homologs) and having the formula C n H 2 n are known as olefins or alkenes ; ( 2 ) those containing one triple bond (acetylene and its homologs) are called acetylenes or alkynes and have the formula C n H 2 n −2 ; ( 3 ) those having two double bonds (allene, 1,3‐butadiene and 1,4‐pentadiene represent three types) are diolefins or alkadienes and also have the formula C n H 2 n −2 ; ( 4 ) those having a large number of double or triple bonds or both double and triple bonds are named in analogous fashion as alkatrienes , alkatetraenes , alkadiynes , alkenynes , and alkadienynes . Aliphatic hydrocarbons are asphyxiants and central nervous system ( CNS ) depressants. Serious toxic effects of aliphatic hydrocarbons include asphyxia and chemical pneumonitis for many paraffins, axonal neuropathy for n ‐hexane, and cancer for 1,3‐butadiene.

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Section: Chronic and Subchronic Toxicitymentioning

confidence: 98%

“…In an inhalation exposure study conducted among male Fischer 344 rats, testicular effects did not persist to 13 weeks at exposures up to 3000 ppm (413). In a study of Sprague-Dawley rats, exposure to 1-hexene was provided orally in a corn oil vehicle at 0, 100, 500, or 1000 mg/kg/day.…”

Section: Reproductive and Developmentalmentioning

confidence: 99%

Aliphatic Hydrocarbons

Carreón¹,

Herrick²

2012

Patty's Toxicology

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“…The applicant only provided data on developmental toxicity studies on two volatiles substances (1‐hexene (Gingell et al., ) and 1‐tetradecene (report not provided by the applicant).…”

Section: Assessmentmentioning

confidence: 99%

Scientific opinion of Flavouring Group Evaluation 503 (FGE.503): grill flavour ‘Grillin’ CB‐200SF’

Silano¹,

Bolognesi²,

Castle³

et al. 2017

EFS2

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The EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF Panel) was requested to deliver a scientific opinion on the implication for human health of the product Grillin' CB-200SF The product is derived from heat-treated high oleic sunflower oil, and intended to be used as a food flavouring with charbroiled or grilled aroma in a wide variety of food categories either in liquid or powder form. Information on manufacturing and compositional data was considered adequate to show the reproducibility of the production process. However, the Panel noted that a substantial amount of the non-volatile fraction of the product could not be identified. The chronic dietary exposure to the substance estimated using the Added Portions Exposure Technique (APET) was calculated to be 60 mg/person per day for a 60-kg adult and 37.8 mg/person per day for a 15-kg child. The data submitted for evaluating the genotoxic potential of the flavouring was considered insufficient. There are still eight substances in the flavouring for which the evaluation of genotoxic potential is pending. No toxicity studies have been provided on the final product itself. Only information on a number of constituents of the flavouring and data on toxicity of several thermally treated fats and oils were provided by the applicant. However, the Panel considered the time-temperature conditions that were applied in the preparation of the substances tested as not comparable to those applied in the course of the production of the flavouring. The Panel concluded that on the basis of the data provided by the applicant the safety of Grillin' CB-200SF cannot be established.

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“…The applicant only provided data on developmental toxicity studies on two volatile substances (1‐hexene (Gingell et al., ) and 1‐tetradecene (report not provided by the applicant).…”

Section: Assessmentmentioning

confidence: 99%

Scientific opinion of Flavouring Group Evaluation 502 (FGE.502): grill flavour ‘Grillin’ 5078’

Silano¹,

Bolognesi²,

Castle³

et al. 2017

EFS2

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The EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF Panel) was requested to deliver a scientific opinion on the implication for human health of the product Grillin' 5078 Information on manufacturing and compositional data was considered adequate to show the reproducibility of the production process. However, the Panel noted that a considerable amount of the non-volatile fraction of the product could not be identified. The chronic dietary exposure to the substance estimated using the Added Portions Exposure Technique (APET) was calculated to be 60 mg/person per day for a 60-kg adult and 37.8 mg/person per day for a 15-kg child. The data submitted for evaluating the genotoxic potential of the flavouring was considered insufficient. There are still 12 substances in the flavouring for which the evaluation of genotoxic potential is pending. No toxicity studies have been provided on the final product itself. Only information on a number of constituents of the flavouring and data on toxicity of several thermally treated fats and oils were provided by the applicant. However, the Panel considered the time-temperature conditions that were applied in the preparation of the substances tested as not comparable to those applied in the course of the production of the flavouring. The Panel concluded that on the basis of the data provided by the applicant the safety of Grillin' 5078 cannot be established.

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Subchronic Inhalation Study of 1-Hexene in Fischer 344 Rats

Cited by 6 publications

References 7 publications

Aliphatic Hydrocarbons

Aliphatic Hydrocarbons

Scientific opinion of Flavouring Group Evaluation 503 (FGE.503): grill flavour ‘Grillin’ CB‐200SF’

Scientific opinion of Flavouring Group Evaluation 502 (FGE.502): grill flavour ‘Grillin’ 5078’

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